Moderna and Flagship Pioneering: Noubar Afeyan

Imane Anys—who goes by the online moniker Pokimane—is the leading female streamer on Twitch, a popular streaming platform for gamers. Pokimane spoke with Guy about garnering more than 20 million followers across several platforms, and how internet personalities can operate their brands like traditional businesses. These conversations are excerpts from our How I Built Resilience series, where Guy talks online with founders and entrepreneurs about how they're navigating turbulent times. Pre-order the How I Built This book at: https://smarturl.it/HowIBuiltThisSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Syys 202025min

Growing up in rural Northern California, Mike Radenbaugh hated biking to high school—it was a 16 mile slog; hilly and tiring. So he scrounged up a battery and a motor, rigged them to an old mountain bike and began cycling to school without breaking a sweat. When Mike's neighbors starting asking him to motorize their bikes, Rad Power Bikes was born. He eventually designed an eye-catching e-bike with fat tires and a throttle that could push any pedaler to 20mph. Today, Rad Power Bikes is the largest e-bike brand in the U.S., and has barely been able to keep up with demand since the pandemic began.Pre-order the How I Built This book at: https://smarturl.it/HowIBuiltThis See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Syys 20201h 10min

KiwiCo delivers science and arts projects to kids on a monthly basis. Sandra Oh Lin founded the company nine years ago, and her team has scrambled to meet demand during the pandemic. These conversations are excerpts from our How I Built Resilience series, where Guy talks online with founders and entrepreneurs about how they're navigating turbulent times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Syys 202019min

COVID-19's impact on the seafood industry hit Luke Holden and Ben Conniff hard; in March they closed their restaurants and laid off 300 employees. Since then, Luke's Lobster has been able to stay afloat by upstarting an e-commerce website, but their focus remains on sustaining the local seafood economy of Maine. These conversations are excerpts from our How I Built Resilience series, where Guy talks online with founders and entrepreneurs about how they're navigating turbulent times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Syys 202023min

One night in 1978, for fun, Sandy Chilewich and her friend, Kathy Moskal, tried bleaching their black cotton shoes, and dyeing them a new color. They were just fooling around in their Manhattan loft, but that experiment sparked the idea for Hue, a line of colorful shoes, stockings, tights, and accessories. It also launched Sandy on a 40-plus year career as a designer and entrepreneur. After selling Hue in 1991, Sandy built up her current, eponymous business based on an innovative design for placemats and other household items made from woven vinyl. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Elo 202043min

Despite the economic crisis, Wayfair has seen an 84 percent sales spike, leading them to profitability during the COVID-19 pandemic. However, co-founders Niraj Shah and Steve Conine have also dealt with unexpected challenges, from hundreds of layoffs in February to employee-staged protests outside Wayfair's office in June. These conversations are excerpts from our How I Built Resilience series, where Guy talks online with founders and entrepreneurs about how they're navigating turbulent times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Elo 202027min

Rinse is a laundry and dry-cleaning app started by college friends Ajay Prakash and James Joun in 2013. Since March, Rinse's dry cleaning service has seen a drop in orders, but their laundry arm has remained steady, allowing them to avoid layoffs during the COVID-19 crisis. These conversations are excerpts from our How I Built Resilience series, where Guy talks online with founders and entrepreneurs about how they're navigating turbulent times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Elo 202021min

After selling their first small business and shuttering their second, former college roommates Niraj Shah and Steve Conine thought about getting "normal" jobs. But in the early 2000s, they stumbled across an unexpected trend: people were buying furniture online to get a wider selection. Within a few years, Niraj and Steve launched 250 different websites, selling everything from barstools to birdhouses. Eventually, they consolidated these sites into one giant brand: Wayfair. The company now carries more than 14 million items for and last year brought in more than $9 billion. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Elo 202041min