Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Dr. Thomas Seyfried is a Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois. He then worked as an assistant professor in the neurology department at the Yale school of medicine. He has over 180 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease. He recently received a Lifetime Achievement Award from the Academy of Complimentary and Integrative Medicine.

I got a chance to meet and interview him at the Metabolic Health Summit earlier this year. You'll notice we did this podcast shortly after the Super Bowl. In case people aren't familiar with American football the New England Patriots had just beaten the LA Rams.

I hope people look up the paper he recently published that we mention and watch his presentation I linked to in the show notes and go deeper on this topic. It's very surprising to learn of this completely new view on cancer if you haven't heard of it before. This really shouldn't be very surprising to anyone, however, because of course our modern diet and lifestyle would have the biggest effect on the rising cancer rates. And of course fixing these things would also be a major part of the treatment. He's really doing legendary work. So without further ado, here's professor Seyfried.

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http://indiegogo.com/projects/food-lies-post

Support me on Patreon! http://patreon.com/peakhuman

Show Notes

  • Dr. Thomas Seyfried believes cancer is a metabolic disease, not a genetic disease and explains in simple terms why that is
  • The mitochondria in your cells make energy (ATP)
  • There's 2 types of energy: ancient energy which is a fermentation metabolism which means you can make energy without oxygen, or respiration where you make energy from breathing air
  • Cancer cells ferment - therefore they don't use oxygen
  • Not all cancer cells have genetic mutations, but all cancer cells ferment
  • The mitochondrial metabolic theory says that the organelle that makes energy from respiration is defective, forcing the cell to ferment. When the cell ferments, mutations collect in the nucleus
  • This means the genetic mutations seen in cancer cells come from a downstream effect of disruption of energy metabolism
  • The cancer cell has to consume a large amount of glucose and the amino acid glutamine in order to survive on a fermentation metabolism
  • On the other hand, normal cells use oxygen and very little amounts of glucose
  • This should make sense to a lot of people because they've probably heard cancer cells need a lot of glucose and if you starve them of that they die
  • Have to re-emphasize the fact that the DNA damage comes as a downstream effect
  • Damaged mitochondria, instead of making ATP, make Reactive Oxygen Species (ROS) or oxidative stress (which causes a lot of problems in our body)
  • The oxidative stress also causes damage to the nucleus and the genome
  • The field of cancer research studies effects instead of causes
  • We're not treating cancer by looking at the root cause - it's absurd - how would we ever cure it?
  • This is supported by thousands of experiments and studies
  • Obvious step to treat cancer is to deprive the cancer cells of glucose and glutamine and transition healthy cells into the use of ketones which they can readily use
  • We evolved as a starving creature and convert fatty acids into ketones and usable forms of energy
  • Cancer cells can't use ketones
  • There's no dietary way to restrict glutamine to the cancer cells so drugs have to be used
  • Basically nobody he's heard of is treating it this way
  • If it's so clear this is how cancer works, why has this not reached the mainstream?
  • The Federal government puts out websites saying cancer is genetic, medical schools teach it's genetic, leading cancer clinics tell patients it's genetic
  • Entrenched beliefs continue this. Also funding money is all based around the genetic theory
  • If you look at the mitochondria of any cancer cell under an electron microscope you can easily see the damage to the organelles and mitochondria
  • Cancer is a result of the industrialization as a society
  • Cancer is so rare throughout history or with non-industrialized societies they don't even have the word for it in their language
  • Cancer comes from all kinds of things like pollution, chemicals, radiation, hypoxia, infections, chronic inflammation, even some rare inherited diseases like BRCA1 (but it has to damage the mitochondria)
  • These are all secondary - the root cause is damage to the respiration
  • Obese people have higher rates of cancer and also higher inflammation (measured by C reactive protein)
  • To avoid cancer it's as simple as avoiding diets and lifestyles that risk damage to the mitochondria
  • Metabolic therapies need to at least be options for people
  • Problem is doctors aren't aware of them or aren't trained on them
  • Therapeutic ketosis is a medicine - it's different than just a diet (which is a turn-off to a lot of medical professionals)
  • There's therapeutic weight loss and toxic weight loss
  • Using a suite of therapies to cure cancer including ketogenic metabolic therapy and hyperbaric oxygen therapy
  • Hyperbaric oxygen creates reactive oxygen species that kills cancer cells but healthy cells using ketones are protected from oxidative stress and are fine
  • Burning ketones creates less ROS (which is a good thing) and is why many people without cancer eat a ketogenic diet
  • ROS damages tissues and is why you age
  • He published the glucose-ketone index calculator
  • People need to realize sweets are a treat once in awhile - not an everyday thing
  • The food industry has played into our ancient desires for sweet
  • Otto Warburg studied cancer in the early 1900s
  • He found that cancer cells would grow in an 100% oxygen environment - they continue to ferment and create lactic acid
  • Because their mitochondria are defective they can't switch back to oxidative phosphorylation
  • He recently published a paper filling in the gaps from Otto Warburg's work
  • Missing link was the glutamine that cancer cells can also use
  • Have to pulse the glutamine so the immune system can do it's job and clear out the dead cells
  • He's developed the press-pulse system in his lab to attack tumors strategically
  • Almost there with dosage, timing, and schedule - when done with this will have the pathway to resolution
  • He's having trouble getting funding for this for some reason
  • One problem is people have created separate little communities and foundations around their specific type of cancer even though they all have the common metabolic foundational problem
  • People are going to have to participate in the management of their disease and the culture of the diseases has to change
  • Another problem is the high cost of these standard therapies - people have to pay $400k
  • His paper looking at research conducted on cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/
  • If you take a normal cytoplasm and implant a nucleus with a tumor you get normal cells. But if you implant a normal nucleus to a cell with damaged cytoplasm, you get more tumor cells. This shows it's the damaged mitochondria in the cytoplasm, not the DNA in the nucleus
  • The wheelchair doesn't cause your legs to not work
  • Needle biopsies are putting people at risk and are pointless
  • He calls this general misunderstanding of cancer the biggest tragedy in the history of medicine
  • What do critics of his views say? They try to create doubt
  • They rely on private funding and some great organizations supporting this research
  • Travis Christofferson's foundation https://foundationformetaboliccancertherapies.com
  • His book Tripping Over the Truth https://www.amazon.com/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/
  • Dr. George Yu's foundation https://yufoundation.org
  • Presentation by Dr. Seyfried https://www.youtube.com/watch?v=APwnkpD_BfI&frags=pl%2Cwn
  • Dr. Seyfried's book https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/

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Film site: http://FoodLies.org

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Jaksot(235)

Part 203 - Dr. Joel Kahn Thinks You Should Go Vegan

Part 203 - Dr. Joel Kahn Thinks You Should Go Vegan

Dr. Joel Kahn is a cardiologist, integrative medicine practitioner and promoter of plant-based nutrition. Having practiced traditional cardiology since 1983, it was only after his own commitment to a plant based vegan diet that he truly began to delve into the realm of non-traditional diagnostic tools, prevention tactics and nutrition-based recovery protocols. These ideologies led him to change his approach and focus on being a holistic cardiologist. https://www.drjoelkahn.com/ GET THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (16:52) According to Dr. Khan, if you suffer from heart disease, consider a plant-based diet based on science. (20:38) We start to develop atherosclerosis in our 20s and 30s. (31:00) We have more than enough data that a human can live through their reproductive years on a huge variety of diets. (47:08) To assess whether or not you're on the right path, assess your own cardiovascular status. (59:54) 30-40% of heart attacks, strokes, and early deaths are due to genetic factors, completely regardless of nutrition and lifestyle. (1:09:50) Examine whether or not your lifestyle is working for you. Don't just assume it is. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

20 Syys 20231h 13min

Part 202 - Stephan Guyenet, PhD on Why Do Humans Overeat?

Part 202 - Stephan Guyenet, PhD on Why Do Humans Overeat?

Stephan J. Guyenet, Ph.D. is an obesity researcher and health writer whose work ties together neuroscience, physiology, evolutionary biology, and nutrition to offer explanations and solutions for our global weight problem. He received a B.S. in biochemistry at the University of Virginia and a Ph.D. in neurobiology at the University of Washington. He is the author of the popular health website, Whole Health Source, and is a frequent speaker on topics of obesity, metabolism, and nutrition. https://www.stephanguyenet.com/about-stephan-guyenet/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (11:16) Our brains determine our food intake and regulate our energy expenditure, in a way that works best in our ancestral environment, but not in our modern environment. (24:33) We consume calories for many reasons, hunger being just one of them. Likewise, satiety is just one of many reasons we stop eating. (34:40) As a rule of thumb, eat a diet of omnivorous whole foods that are lower in calorie density. (49:56) Fiber is not an essential nutrient. (58:35) Nutrient-to-energy is important to health, but once you have adequate intake, there's not much benefit in taking in more. (1:04:46) Most people in the US are more susceptible to obesity than others. Whether or not they actually become obese comes down to the environment they choose. (1:15:31) Blood pressure, on a genetic level, doesn't typically change as one gets older. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

12 Syys 20231h 26min

Part 201 - Brad Kearns on Finding the Holy Grail of Diet & Lifestyle

Part 201 - Brad Kearns on Finding the Holy Grail of Diet & Lifestyle

Brad Kearns, 58, is a New York Times bestselling author, Guinness World Record setting professional Speedgolfer, #1 USA-ranked Masters age 55-59 track & field high jumper in 2020, and former national champion and #3 world-ranked professional triathlete. He has written twenty books on diet, health, peak performance, and ancestral living, and is a popular speaker, retreat host, and face of the Primal Blueprint online multimedia educational courses. In 2017, The Keto Reset Diet became a New York Times bestseller, and briefly ranked as the #1 overall bestselling book on amazon.com. Brad also hosts the B.rad podcast BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (09:56) We know what's possible. Now let's shoot for optimal. (21:22) Processed foods disrupt our appetite and satiety hormones, prompting us to overeat. (33:02) Injuries are a sign of overdoing it. (40:56) Homo sapiens are built for near-constant everyday movement. (47:38) Always ask "what's optimal" instead of just "what's possible". (59:54) Raw forms of high-toxin natural plant foods is a potentially problematic category of nutrition. (1:08:26) Our main nutritional challenge is energy toxicity. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

31 Elo 20231h 24min

Part 200 - My biggest impact fat loss & health tips

Part 200 - My biggest impact fat loss & health tips

This episode features the synthesis of my learnings after doing 200 episodes over the last 5.5 years with many of the world's top doctors & scientists in the health field. Get 80% of the results with 20% of the effort. I've dedicated my life to learning from the best and distilling things down to actionable insights that make it easy for you to get results. Today my sister interviews me in an episode packed with useful info. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (10:52) The only nutrition plan you'll be able to stick with for the long-term is the one that you enjoy following, and is both nutrient-dense and complete. (24:58) Food Lies was originally a documentary that turned into a six-part series. (29:43) The Sapien Center can be described as a work-from-home health-focused community that makes the journey to health and longevity sustainable and fun. (36:36) Ancestral health combines how humans traditionally ate with modern medicine to prevent and treat chronic disease. (49:25) The main problem with binge eating dietitians and the fat acceptance movement is that they do not understand that there are differences in food. (57:34) Nutrient calories are not the same as energy calories. (1:07:25) Cholesterol is foundational to hormonal health. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

16 Elo 20231h 20min

Part 199 - Tucker Max on Raising Your Own Food, Providing for Your Family, and the Future of Freedom

Part 199 - Tucker Max on Raising Your Own Food, Providing for Your Family, and the Future of Freedom

Tucker Max has written four New York Times Best Selling books (three that hit #1), which have sold over 4.5 million copies worldwide. He co-founded Scribe Media, the premier professional publishing company that has helped people like David Goggins, Tiffany Haddish and Dan Sullivan publish their books. He was nominated to the Time Magazine 100 Most Influential List in 2009. He received his BA from the University of Chicago in 1998, and his JD from Duke Law School in 2001. He currently lives on a ranch in Dripping Springs, Texas, with his wife Veronica and five children on a homestead ranch where they raise animals, grow their own food, and create sustainable and redundant systems to be self-sufficient. They also helped start an alternative school with their community. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (14:30) Consuming content endlessly from media personalities is not all that different to binging soap operas. (22:56) Whether or not you develop type 2 diabetes does depend on genetics, but a huge, often-overlooked factor is how your diet looks. (25:51) To Tucker, Waldorf is the ideal homeschooling curriculum for its heavy emphasis on student-led education. (40:15) "The only reason hospitals aren't cesspools of death is because nurses keep it together." (44:37) True sovereignty over your family's livelihood comes down to owning your own sources of food, water, and power. (50:08) Don't be an oldschool doomsday prepper. Control your inputs. (53:43) Taking responsibility for your livelihood—for your food, water, and power, education, and health—creates a sense of urgency in your life. (1:00:35) The COVID-19 crisis taught Tucker to ask himself the two-part question: "What do I believe and why do I believe it?" (1:11:25) Creating your own society starts with the actions you take. Website I mentioned https://www.sovereignhumans.org/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

9 Elo 20231h 23min

Part 198 - Mark Sisson on Health From Your Feet On Up

Part 198 - Mark Sisson on Health From Your Feet On Up

Mark Sisson is a renowned health and fitness expert, author, and entrepreneur, celebrated for pioneering the primal lifestyle movements. Once a competitive endurance athlete who achieved a top-five finish in the Ironman World Championship, he is now a successful businessman who founded Primal Kitchen, a purveyor of paleo-friendly foods and supplements, bought by Kraft Heinz in 2018. In addition to his business ventures, he's a bestselling author, with works like "The Primal Blueprint" that promote ancestral eating and exercise habits for health optimization. Recently, Sisson embarked on a new entrepreneurial journey with his son, Kyle, to create Peluva, a better-for-your-body shoe company. He still produces content on his legendary blog, "Mark's Daily Apple," and is absolutely ripped and supremely healthy despite turning 70 next month. Get 10% off Mark's new shoes https://peluva.com/discount/SAPIEN Video version: https://youtu.be/A3jQXP9y5Uo   BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post   SHOW NOTES:   00:00:00 Introduction to Mark Sisson and his shoe company, Peluva.  00:05:00 Talking about NoseToTail.org and the great products  00:10:00 Sisson's insights on modern running shoes and his journey to designing minimalist shoes.  00:15:00 Emphasis on foot health and the drawbacks of cushioned shoes.  00:20:00 Sisson dispels misconceptions about orthotics, advocates minimalist shoes, and introduces Peluva's Strand model.  00:25:00 Sisson discusses human feet evolution, barefoot experience benefits, and safe transition to minimal shoes.  00:30:00 Importance of toe articulation and foot strength training, promoted through Peluva shoes.  00:35:00 Overview of Peluva's different shoe models and their applications. 00:40:00 Critique of cushioned shoes and the benefits of minimalist footwear for foot mobility.  00:45:00 Sisson talks about the role of walking, exercise, and his personal dietary habits.  00:50:00 Sisson outlines his daily routine, metabolic flexibility, and the value of nutrient-dense diets.  00:55:00 Discussion on caloric value of nutrients, protein-centric diets, and metabolic flexibility.  01:00:00 Closing with Sisson promoting Peluva (use code SAPIEN to get 10% off) and his ambition to globally improve foot health. Get 10% off Mark's new shoes https://peluva.com/discount/SAPIEN   BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post       Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

21 Kesä 202357min

Part 197 - Chris Knobbe, MD on Why Seed Oils are The Single Most Harmful Ingredient in the Human Diet

Part 197 - Chris Knobbe, MD on Why Seed Oils are The Single Most Harmful Ingredient in the Human Diet

Chris Knobbe, MD, is a physician, researcher, ophthalmologist, public health advocate, and Associate Clinical Professor Emeritus, formerly of the University of Texas Southwestern Medical Center in Dallas, Texas. Dr. Knobbe is known primarily for his research, publications, and presentations connecting Westernized diets and highly polyunsaturated vegetable oils to numerous chronic diseases, including coronary heart disease, hypertension, stroke, cancers, type 2 diabetes, metabolic syndrome, obesity, Alzheimer's disease, autoimmune diseases, and age-related macular degeneration (AMD). Dr. Knobbe's research has focused greatly on the "vegetable oil hypothesis" as the primary driver of overweight and chronic disease. In 2016, Knobbe formally introduced the hypothesis that processed foods and vegetable oils are the primary drivers of AMD, which is the leading cause of irreversible vision loss and blindness in people over the age of 50, worldwide. GET THE MEAT: http://NosetoTail.org FREE SAPIEN FOOD GUIDE: http://sapien.org SHOW NOTES (3:06) Dr. Chris Knobbe's latest publication: Ancestral Diet Revolution (4:54) How Dr. Knobbe left his ophthalmologist practice in 2015 to pursue the topic of seed oils (6:10) The connection between age-related macular degeneration and diet (12:06) Dr. Chris Knobbes impactful use of data and graphs (14:43) Why are seed oils more concerning than other processed foods? (41:31) Dietary changes in populations across the globe and prevalence of disease- the modern displacement of foods (1:04:49) The effect of sugar vs. vegetable oils on the rate of incidence in the United States (1:18:30): Dietary lipid profile is a determinant of tissue phospholipid fatty acid composition and rate of weight gain in rats (https://pubmed.ncbi.nlm.nih.gov/8463854/) (1:26:40) Seeds oils and poor diet as a driver for cancer (1:34:23) Diet and lifestyle is crucial in determining health outcomes regardless of genetics GET THE MEAT: http://NosetoTail.org FREE SAPIEN FOOD GUIDE: http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

13 Kesä 20231h 34min

Part 196 - Kyle Lasota on Unlocking The Natural Limitless Pill Through Sleep Optimization

Part 196 - Kyle Lasota on Unlocking The Natural Limitless Pill Through Sleep Optimization

On this episode, Brian interviews, Kyle Lasota a Sleep Expert, Biohacker, and YouTuber. Kyle has spent over $150,000 on his own personal health and has helped 1,000's of people transform their sleep. Kyle breaks down exactly how you can start improving your sleep and achieve new levels of performance you previously never had access to. Using these practical biological principles and psychological triggers, he says, anyone can master their sleep. https://www.thesleepadvantage.co/sapien Check out the free video and the course above

25 Touko 20231h 23min

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