Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Dr. Thomas Seyfried is a Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois. He then worked as an assistant professor in the neurology department at the Yale school of medicine. He has over 180 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease. He recently received a Lifetime Achievement Award from the Academy of Complimentary and Integrative Medicine.

I got a chance to meet and interview him at the Metabolic Health Summit earlier this year. You'll notice we did this podcast shortly after the Super Bowl. In case people aren't familiar with American football the New England Patriots had just beaten the LA Rams.

I hope people look up the paper he recently published that we mention and watch his presentation I linked to in the show notes and go deeper on this topic. It's very surprising to learn of this completely new view on cancer if you haven't heard of it before. This really shouldn't be very surprising to anyone, however, because of course our modern diet and lifestyle would have the biggest effect on the rising cancer rates. And of course fixing these things would also be a major part of the treatment. He's really doing legendary work. So without further ado, here's professor Seyfried.

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Show Notes

  • Dr. Thomas Seyfried believes cancer is a metabolic disease, not a genetic disease and explains in simple terms why that is
  • The mitochondria in your cells make energy (ATP)
  • There's 2 types of energy: ancient energy which is a fermentation metabolism which means you can make energy without oxygen, or respiration where you make energy from breathing air
  • Cancer cells ferment - therefore they don't use oxygen
  • Not all cancer cells have genetic mutations, but all cancer cells ferment
  • The mitochondrial metabolic theory says that the organelle that makes energy from respiration is defective, forcing the cell to ferment. When the cell ferments, mutations collect in the nucleus
  • This means the genetic mutations seen in cancer cells come from a downstream effect of disruption of energy metabolism
  • The cancer cell has to consume a large amount of glucose and the amino acid glutamine in order to survive on a fermentation metabolism
  • On the other hand, normal cells use oxygen and very little amounts of glucose
  • This should make sense to a lot of people because they've probably heard cancer cells need a lot of glucose and if you starve them of that they die
  • Have to re-emphasize the fact that the DNA damage comes as a downstream effect
  • Damaged mitochondria, instead of making ATP, make Reactive Oxygen Species (ROS) or oxidative stress (which causes a lot of problems in our body)
  • The oxidative stress also causes damage to the nucleus and the genome
  • The field of cancer research studies effects instead of causes
  • We're not treating cancer by looking at the root cause - it's absurd - how would we ever cure it?
  • This is supported by thousands of experiments and studies
  • Obvious step to treat cancer is to deprive the cancer cells of glucose and glutamine and transition healthy cells into the use of ketones which they can readily use
  • We evolved as a starving creature and convert fatty acids into ketones and usable forms of energy
  • Cancer cells can't use ketones
  • There's no dietary way to restrict glutamine to the cancer cells so drugs have to be used
  • Basically nobody he's heard of is treating it this way
  • If it's so clear this is how cancer works, why has this not reached the mainstream?
  • The Federal government puts out websites saying cancer is genetic, medical schools teach it's genetic, leading cancer clinics tell patients it's genetic
  • Entrenched beliefs continue this. Also funding money is all based around the genetic theory
  • If you look at the mitochondria of any cancer cell under an electron microscope you can easily see the damage to the organelles and mitochondria
  • Cancer is a result of the industrialization as a society
  • Cancer is so rare throughout history or with non-industrialized societies they don't even have the word for it in their language
  • Cancer comes from all kinds of things like pollution, chemicals, radiation, hypoxia, infections, chronic inflammation, even some rare inherited diseases like BRCA1 (but it has to damage the mitochondria)
  • These are all secondary - the root cause is damage to the respiration
  • Obese people have higher rates of cancer and also higher inflammation (measured by C reactive protein)
  • To avoid cancer it's as simple as avoiding diets and lifestyles that risk damage to the mitochondria
  • Metabolic therapies need to at least be options for people
  • Problem is doctors aren't aware of them or aren't trained on them
  • Therapeutic ketosis is a medicine - it's different than just a diet (which is a turn-off to a lot of medical professionals)
  • There's therapeutic weight loss and toxic weight loss
  • Using a suite of therapies to cure cancer including ketogenic metabolic therapy and hyperbaric oxygen therapy
  • Hyperbaric oxygen creates reactive oxygen species that kills cancer cells but healthy cells using ketones are protected from oxidative stress and are fine
  • Burning ketones creates less ROS (which is a good thing) and is why many people without cancer eat a ketogenic diet
  • ROS damages tissues and is why you age
  • He published the glucose-ketone index calculator
  • People need to realize sweets are a treat once in awhile - not an everyday thing
  • The food industry has played into our ancient desires for sweet
  • Otto Warburg studied cancer in the early 1900s
  • He found that cancer cells would grow in an 100% oxygen environment - they continue to ferment and create lactic acid
  • Because their mitochondria are defective they can't switch back to oxidative phosphorylation
  • He recently published a paper filling in the gaps from Otto Warburg's work
  • Missing link was the glutamine that cancer cells can also use
  • Have to pulse the glutamine so the immune system can do it's job and clear out the dead cells
  • He's developed the press-pulse system in his lab to attack tumors strategically
  • Almost there with dosage, timing, and schedule - when done with this will have the pathway to resolution
  • He's having trouble getting funding for this for some reason
  • One problem is people have created separate little communities and foundations around their specific type of cancer even though they all have the common metabolic foundational problem
  • People are going to have to participate in the management of their disease and the culture of the diseases has to change
  • Another problem is the high cost of these standard therapies - people have to pay $400k
  • His paper looking at research conducted on cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/
  • If you take a normal cytoplasm and implant a nucleus with a tumor you get normal cells. But if you implant a normal nucleus to a cell with damaged cytoplasm, you get more tumor cells. This shows it's the damaged mitochondria in the cytoplasm, not the DNA in the nucleus
  • The wheelchair doesn't cause your legs to not work
  • Needle biopsies are putting people at risk and are pointless
  • He calls this general misunderstanding of cancer the biggest tragedy in the history of medicine
  • What do critics of his views say? They try to create doubt
  • They rely on private funding and some great organizations supporting this research
  • Travis Christofferson's foundation https://foundationformetaboliccancertherapies.com
  • His book Tripping Over the Truth https://www.amazon.com/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/
  • Dr. George Yu's foundation https://yufoundation.org
  • Presentation by Dr. Seyfried https://www.youtube.com/watch?v=APwnkpD_BfI&frags=pl%2Cwn
  • Dr. Seyfried's book https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/

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Jaksot(235)

Part 195 - Tara Couture on Incredible Health with the Ultimate Human Lifestyle

Part 195 - Tara Couture on Incredible Health with the Ultimate Human Lifestyle

Tara Couture is one of the most sensational humans the world has to offer. She is a retired Registered Holistic Nutritionist and mother of 3 amazing girls. She and her husband Troy, who works as an ER Doctor, live and manage their homestead farm where they raise and butcher all their own animals. She nourishes her family with nose to tail, regeneratively grown, beyond organic food. Show Notes coming soon!

18 Touko 20231h 30min

Part 194 - Dr. Martin Gorman on The Scary Truth about Sleep Apnea and how to fix it

Part 194 - Dr. Martin Gorman on The Scary Truth about Sleep Apnea and how to fix it

Dr. Martin Gorman, a Bioesthetic trained Dental Practitioner with over 40 years of experience, and very knowledgeable expert in Temporomandibular Joint Dysfunction, Sleep disorders, and epigenetic orthodontics. Dr. Gorman describes his path into the field of sleep-breathing disorders, highlighting the effect of TMJ disorders on optimal airway patency as well as how this relates to breathing disorders, facial appearance, general well-being, and several predominant medical conditions. Website: https://www.mgormandental.com/about/ Key Takeaways (simple version) (00:09) Getting a palate expansion (03:10) Dr. Gorman's journey with Sleep Apnea (06:42) About the jaw expansion work by Steven Lamberg (14:50) The scale of the problem of sleep apnea (20:16) The evolution of sleep tests (26:41) Dr. Gorman's new product that combines expansion and orthodontic treatment. (30:35) How Dr. Gorman's appliance works and its benefits. (35:30) With the rising rate of heart attacks, there is now a scan that can show the level of cholesterol in blood vessels. (42:08) Most diseases have a root cause in sleep, diet, or lifestyle. (48:44) The side of your face that looks bad is the side of your head that did not develop well. (54:25) Comparing the roles of nutrition and physical activity in developing the proper jaw in kids.

4 Touko 20231h 12min

Part 193 - Dr. Andreas Eenfeldt on the Impactful Concept to Lose Fat - Satiety and Satiety Score

Part 193 - Dr. Andreas Eenfeldt on the Impactful Concept to Lose Fat - Satiety and Satiety Score

Dr. Andreas Eenfeldt is a Swedish medical doctor specialized in family medicine and the founder and CEO of Diet Doctor, a fast-growing health company. He graduated from medical school at Uppsala University in 2000 and spent twelve years working as a doctor, treating patients with low-carb, high-fat diets. In 2015, he quit to focus on Diet Doctor, which is completely free from ads, product sales, or industry sponsorship and is instead funded by an optional membership. Dr. Eenfeldt is also on the board of The Dietary Science Foundation, a non-profit dedicated to improving scientific knowledge and helping people live healthier lives. Website: https://www.dietdoctor.com/authors/dr-andreas-eenfeldt Twitter: https://twitter.com/DrEenfeldt Linkedin: https://www.linkedin.com/in/dietdoctor/ Key Takeaways (simple version) (04:12) Satiety is not just about energy balance or calories-in, calories-out, but offers a flexible approach to nutrition that can be tailored to the individual. (09:12) Carbs aren't the problem as much as the type of carbs you eat, and how many calories you consume in a day. (18:40) Prioritizing satiety, particularly through the consumption of high-quality protein, ensures we don't overeat. (24:58) The satiety approach is flawed… but its flaws are few compared to virtually all the mainstream diets out there. (46:53) Satiety can be thought of as an antifragile approach, in that criticism of the concept or evidence that appears to suggest the contrary only end up making the concept more robust. (55:52) People tend to eat more when their energy density is high. (58:21) You don't need fiber on a low-carb diet, but one thing it does help with is satiety. (1:11:01) A healthy microbiome doesn't necessarily lead to increased metabolic health, nor is it a solution to obesity. (1:14:26) Dr. Eenfeldt gives his thoughts on the recent debate between Dr. Nick Norwitz and Dr. Ted Naman on the satiety approach.

25 Huhti 20231h 23min

Part 192 - Ashley and Sarah Armstrong on Breaking Free from the Low Carb Myth

Part 192 - Ashley and Sarah Armstrong on Breaking Free from the Low Carb Myth

Ashley and Sarah Armstrong, aka The Strong Sistas, are powerlifters and nutritional coaches who are passionate about bioenergetic nutrition and regenerative agriculture. Suffering from autoimmune disease, the sisters have adopted an animal based lifestyle, utilizing the Carnivore Diet and the Ketogenic Diet, which has transformed their lives. Today, they live on a regenerative farm in Michigan and, in addition to their coaching practice, co-host the Rooted in Resilience Podcast.  Website: https://www.armstrongsisters.com/ Instagram: https://www.instagram.com/strong.sistas/ Youtube: https://www.youtube.com/@StrongSistas/featured Show Notes  (04:59) Your ability to produce energy, resist disease, and eat a wide variety of foods is developed in the environment you grew up in. (12:38) We need to develop food awareness rather than food fear. (19:57) Reduce your endotoxin load to mitigate its negative impact on estrogen and serotonin. (31:58) There are many misconceptions around PUFAs and saturated fat. (40:27) A weight loss program can result in health issues because even a short-term caloric deficit leads to a significant decrease in thyroid hormone conversion from T4 to T3. (50:29) Calories-in, calories-out does matter; but, the state of your thyroid impacts your basal metabolic rate. (55:50) Ease of digestion should be considered when determining what to prioritize in your diet. (1:05:32) Dr. Ray Peat believes that the small intestine should be relatively sterile (1:13:09) Putting on muscle is extremely advantageous to women over 30.

18 Huhti 20231h 29min

Part 191 - Calley Means on How the Sickcare System Cons the World for Trillions

Part 191 - Calley Means on How the Sickcare System Cons the World for Trillions

Calley Means is the cofounder of True Medicine, which enables patients to use HSAs/FSAs to buy healthy food, exercise and supplements. He is writing a book, co-authored with his sister Dr. Casey Means, about how preventable cellular dysfunction (caused primarily by food) is at the root of nearly every chronic condition that plagues American life – and how to fix it. https://calleymeans.com/ Calley has invested in healthcare companies aiming to transform the current sick-care system, including Levels (providing patients with more metabolic health data), Atai (a leading mental health/psychedelic company), Delix (a leading psychedelic company), and Rejuveron (a leading longevity company), as well as consumer startups such as RapidSOS, UpSmith, Dynamic.xyz, and Vibe. Previously, Calley co-founded a company called Anomalie with his wife, which was acquired by David's Bridal. Anomalie's solution is the only customizable, made-to-order bridal brand that helps brides of all sizes, styles, and budgets visualize and create their perfect dream dress. https://twitter.com/calleymeans https://www.instagram.com/calleymeans/ https://www.linkedin.com/in/calley-means-a29b5512/ SHOW NOTES: (12:02) Is the growth of the healthcare industry correlated with better outcomes? (18:54) Humans and domesticated animals are the only creatures struggling with systematic obesity, depression, and metabolic dysfunction. (24:45) The average American today goes through 17 different medical specialists throughout their life. (30:59) Most forms of cancer aren't "unlucky". They're very preventable. (44:01) Food, alongside other metabolic habits, are causing not just a health epidemic in the U.S., but economic and political turmoil as well. (54:17) The American Diabetes Association said that as long as you take your drugs (if you're Type 2 diabetic) you can eat whatever you want. (56:43) Ultra-processed food is made up of highly-processed grains, sugar, and seed oils. (1:02:16) The USDA recommends up to 10% of our diet to be added sugar, nudging us into funding our destruction. (1:13:16) Is there any way, right now, without waiting for policy change, to use our current health benefits to buy root cause habits? GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

12 Huhti 20231h 24min

Part 190 - Dr. Ted Naiman & Nick Norwitz, PhD and the Food System Scoring Wars

Part 190 - Dr. Ted Naiman & Nick Norwitz, PhD and the Food System Scoring Wars

Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading major medical center in Seattle. Senior Science and Communication Advisor for DietDoctor.com. His research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He has an undergraduate degree in mechanical engineering and utilizes engineering principles when dealing with complex systems such as human health and nutrition. https://tednaiman.com/ Dr. Nicholas Norwitz obtained his PhD in ketogenic nutrition and metabolism from Oxford University and is pursuing his MD at Harvard Medical School. He is a certified Metabolic Health Practitioner (MHP), and the author of peer-reviewed scientific papers and textbook chapters on topics including Alzheimer's disease, cardiovascular disease, diabetes, gastrointestinal health, genetics, osteology, and Parkinson's disease, as well as a blogger and lecturer on the application of the ketogenic diet as metabolic medicine. https://twitter.com/nicknorwitz GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: [9:49] What is the idea of a healthy diet for a day? [13:05] The biggest factor in the obesity crisis. [17:19] Which is more important: food or exercise? [23:23] Are seed oils poison? [29:08] Satiety Per Calorie concept. [34:05] Is Nutrient Density scoring system going to work? [50:41] Satiety Per Calorie scoring system complexity. [1:13:50] Can the Diet Doctor resource scores be harmful for patients? [1:19:20] What is the Carbohydrate Insulin Model? [1:23:25] What all these models can not explain? [1:32:36] Is it possible to create a scoring system that would be generalizable? Studies: [44:35] https://pubmed.ncbi.nlm.nih.gov/30429127/ https://insight.jci.org/articles/view/128308 https://www.cell.com/cell/pdf/S0092-8674(22)00919-9.pdf [1:17:00] https://pubmed.ncbi.nlm.nih.gov/18805087/ https://pubmed.ncbi.nlm.nih.gov/23376733/ https://pubmed.ncbi.nlm.nih.gov/12672919/ https://pubmed.ncbi.nlm.nih.gov/17437143/ [1:24:11] https://pubmed.ncbi.nlm.nih.gov/32666008/ [1:25:46] and [1:29:12] https://www.sciencedirect.com/science/article/pii/S0002916522106167?via%3Dihub GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

4 Huhti 20231h 47min

Part 189 - DEBATE: Should You Eat Carbs For Muscle Growth? Logan Delgado & Robert Sikes

Part 189 - DEBATE: Should You Eat Carbs For Muscle Growth? Logan Delgado & Robert Sikes

Robert Sikes (@ketosavage) is the Keto Savage, Founder of the Keto Brick, and accomplished Keto Bodybuilder. Robert is the author of the new book - Ketogenic Bodybuilding, a Natural Athlete's Guide to Complete Savagery which is the culmination of his research and experience over the past 7 years of ketogenic natural bodybuilding, earning his pro card, and working with hundreds of clients. Robert hosts the Keto Savage podcast, the popular Keto Savage youtube channel with vlogs, cooking demos, and he also coaches clients through online coaching to improve their health, performance, and body composition. Logan Delgado, also known as GoodyBeats, is the co-founder and chief brand officer of BioCoach. Logan used to be 225lbs, overweight and out of shape and completely transformed his life through nutrition and exercise. A YouTuber, husband & father of two little girls, Logan is a huge inspiration in the health space and works his butt off every day to build a bigger following and influence to help motivate people! If you want some serious diet, workout, and life motivation give him a follow. Instagram: @goodybeats YouTube: https://www.youtube.com/channel/UCfLrsGeU0MJNw8o5aDdt5Bw GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: (16:40) Be aware of how emotions play into your dietary choices, and never rely on willpower alone to keep you on track. (31:54) Sustainability is key to any dietary protocol. (37:10) A species-appropriate diet is not a high-carbohydrate diet, and especially not one made of highly-refined carbohydrates. (44:36) Diets are simple, but people are complicated. (59:34) Familiarize yourself with the nutritional makeup of the foods you eat on a daily basis. (1:05:45) Carbs can help in muscle-building as long as the other pieces of the puzzle are in place. (1:17:46) Building muscle has a myriad of benefits for everyone. This is part of the new Peak Human Debate Series where I talk to leading doctors, scientists, and health influencers about controversial topics. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

29 Maalis 20231h 35min

Part 188 - Dr. Kwadwo Kyeremanteng on Taking Control of Your Own Health

Part 188 - Dr. Kwadwo Kyeremanteng on Taking Control of Your Own Health

Brian sits with Dr. Kwadwo Kyeremanteng, an ICU Physician, and Head of the ICU Department, who also has a background in palliative care. Working on research into ways to make the healthcare system more sustainable, Dr. Kwadwo created the Resource Optimization Network and hosts the Solving Healthcare podcast. In his work Dr. Kwadwo noticed the relationship between metabolic syndrome or other underlying chronic conditions and covid outcomes. Following this, he took up a mission to empower patients with tools and knowledge to make healthy life choices that prevent and even reverse these diseases. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: (07:43) Facing the pandemic, Dr. Kwadwo's mission was to inform people about crucial factors that affect covid outcomes. (16:40) Many doctors are also struggling to balance their work with healthy living (19:35) How do doctors respond to the newer dietary recommendations as against the typical nutritional training? (17:34) The rigidity of doctors, whether due to ego or fear of being wrong, played out negatively in the pandemic. (24:57) Dr. Kwadwo has seen no case of a healthy patient ending up in the ICU due to covid-19. (35:53) The protein hack. (46:55) How can all these health strategies be passed across to the larger public? (54:00) How do families implement these changes? GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

15 Maalis 20231h

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