10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1429)

Dr. Daniel Amen: Alzheimer’s, Brain Food & SPECT Scans - #227

Dr. Daniel Amen: Alzheimer’s, Brain Food & SPECT Scans - #227

Why you should listen –  Dr. Amen comes on Bulletproof Radio today to discuss healing toxic brains, Alzheimer’s and dementia, and how SPECT scans can upgrade your life. Enjoy the show! Dr. Daniel Amen is a physician, double board certified psychiatrist, nine-time New York Times bestselling author, Founder and CEO of Amen Clinics.  He has written, produced and hosted 9 popular shows about the brain that have aired over 70,000 times across North America and have raised more than $52 million dollars for public television.  His work has been featured in Newsweek, Time, Huffington Post, ABC World News, 20/20, BBC, London Telegraph, Parade Magazine, Washington Post, LA Times, Men’s Health, Bottom Line, and Cosmopolitan. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Kesä 201558min

Jake Ducey: Public Speaking, Travelling & Dropping Out of College - #226

Jake Ducey: Public Speaking, Travelling & Dropping Out of College - #226

Why you should listen –  Jake Ducey comes on Bulletproof Radio today to discuss becoming a writer, dropping out of school, traveling the world, and the art of public speaking. Enjoy the show! Jake Ducey is an author and speaker at 19 he independently released his first book, “Into the Wind,” about quitting college basketball to travel the world. Ducey then became the youngest motivational author to sign a book deal with Penguin/Random-House for his second book, “The Purpose Principles.” This spring he will embark on one of the largest book tours ever which will be filmed and produced into a major documentary about his generation. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Kesä 201546min

Emily Fletcher: Ziva Meditation, Improving Sleep & Better Sex - #224

Emily Fletcher: Ziva Meditation, Improving Sleep & Better Sex - #224

Why you should listen –  Emily Fletcher comes on Bulletproof Radio today to discuss online meditation, how the right and left brain work, the “balancing breath” technique, and meditating for better sex. Enjoy the show! Emily Fletcher is the founder of Ziva Meditation and the creator of zivaMIND, the first online meditation training program. She began her meditation training in Rishikesh, India and was inspired to become a meditation teacher after experiencing the profound physical and mental benefits it provided her during her 10-year career on Broadway.  She has taught at Google, Harvard Business School, Viacom, and Summit Series.  She has also been featured in The New York Times, Huff Post LIVE and Mind Body Green. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Kesä 20151h 7min

Gary Taubes: Bad Science, Gut Health, & NuSi - #223

Gary Taubes: Bad Science, Gut Health, & NuSi - #223

Gary comes on Bulletproof Radio to discuss the bad science in public health, researching healthy diets, the role of gut bacteria in obesity, and self experimentation. Enjoy the show! Gary Taubes is an American science writer. He is the author of Good Calories, Bad Calories which is titled The Diet Delusion in the UK and Why We Get Fat. He has won the Science in Society Award of the National Association of Science Writers three times and was awarded an MIT Knight Science Journalism Fellowship for 1996-97. He is also a co-founder of Nutrition Science Initiative. NuSI’s mission is reduce the individual, social, and economic costs of obesity, diabetes, and their related diseases by improving the quality of science in nutrition and obesity research. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Touko 201559min

Dr. John Gray: Addiction, Sexuality, & ADD  - #222

Dr. John Gray: Addiction, Sexuality, & ADD - #222

Best selling author of the wildly successful book, Men are from Mars, Women are from Venus, John Gray comes on Bulletproof Radio to discuss causes and natural remedies for ADD, flow states and addiction, gender differences in relationships, and Taoist principles of sexuality. Enjoy the show! John Gray is the best-selling relationship author of all time and the most trusted voice in relationships today. He is the author of 17 books, including The New York Times # Best-Selling Book, Men Are From Mars, Women Are From Venus. His books have sold over 50 million copies in 50 different languages around the world. For more than 35 years he has conducted public and private seminars for thousands of participants. He is a popular speaker and has appeared on Oprah, The Dr. Oz Show, Good Morning America, The Today Show, The CBS Morning Show, Live with Regis, Larry King Live, CNN and many others. John’s purpose is to create a world where men and women understand, respect, and appreciate their differences and ultimately work together. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Touko 20151h 7min

Bulletproof Radio Short Report - Moldy - #221

Bulletproof Radio Short Report - Moldy - #221

Why you should listen -  The Bulletproof Radio Short Report is a highly condensed show to quickly bring you the most important ways to upgrade yourself and kick ass at life. Enjoy the show! Todays episode was shot during PaleoF(x), one of the largest Paleo conferences in the country, where I had the privilege to give a keynote address. Today’s short report is about my upcoming Moldy documentary, mold toxins in our coffee, and how mold exposure makes you weak, sick, and fat.   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Touko 201512min

Alberto Villoldo: Brain Hacking, Breathing Techniques & One Spirit Medicine - #220

Alberto Villoldo: Brain Hacking, Breathing Techniques & One Spirit Medicine - #220

Alberto Villoldo, Ph.D., is a psychologist and medical anthropologist, a best-selling author and founder in the world-renowned Institute of Energy Medicine, The Four Winds Society.  He was the youngest clinical professor at San Francisco State University where he directed his own laboratory, the Biological Self-Regulation Lab, investigating how energy medicine and visualization could change brain chemistry.  He spent 25 plus years studying the healing practices of the Amazon and Inka shamans, and the producer of a documentary film, Amazonia: Healing With Sacred Plants. Why you should listen - Alberto Villoldo comes on Bulletproof Radio today to discuss healing with ayahuasca, hacking your brain, supplementing, and his new book One Spirit Medicine. Enjoy the show!   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Touko 20151h 1min

Nick Ortner: The Tapping Solution for Pain Relief - #219

Nick Ortner: The Tapping Solution for Pain Relief - #219

Nick Ortner is CEO of The Tapping Solution, a company with a mission to bring simple, effect, natural healing into the mainstream through “tapping.” He is a bestselling author with his book, “The Tapping Solution: A Revolutionary System for Stress-Free Living.” Nick is the creator and producer of a breakthrough documentary film, “The Tapping Solution,” which chronicles ten people overcoming tremendous challenges using tapping. He has presented live tapping sessions and shared the stage with speakers of the caliber of Wayne Dyer, Louise Hay, Jack Canfield, Bob Proctor, Lynne McTaggart, and others. Why you should listen -  Nick Ortner comes on Bulletproof Radio today to explain what “tapping” actually is, how tapping was discovered, how tapping can help pain and stress, and his new book “The Tapping Solution for Pain Relief”. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Touko 201551min

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