10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1429)

   Jonathan Bailor: SANE Solutions, Counting Calories & Online Trolls - #210  

   Jonathan Bailor: SANE Solutions, Counting Calories & Online Trolls - #210  

Why you should listen –     Jonathan Bailor comes on Bulletproof Radio to discuss SANE Solutions a new way to understand your food, why quality over quantity is important, and why calorie counting doesn’t work. Enjoy the show!     Jonathan Bailor is a New York Times bestselling author and internationally recognized wellness expert who specializes in using modern science and technology to simplify health. Bailor has collaborated with top scientists for more than 10 years to analyze and apply over 1,300 studies. His work has been endorsed by top doctors and scientists from Harvard Medical School, Johns’ Hopkins, The Mayo Clinic, The Cleveland Clinic, and UCLA.    Bailor is the founder of SANESolution.com and serves as the CEO for the wellness technology company Yopti®. He authored the New York Times and USA Today bestselling book The Calorie Myth, hosts a popular syndicated health radio show The SANE Show and blogs on The Huffington Post. Additionally, Bailor has registered over 25 patents, spoken at Fortune 100 companies and TED conferences for over a decade, and served as a Senior Program Manager at Microsoft where he helped create Nike+ Kinect Training and XBox Fitness.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Huhti 201555min

David Waknine: Adversity, Filming A Documentary & Weight Loss - #209

David Waknine: Adversity, Filming A Documentary & Weight Loss - #209

Why you should listen – David Waknine comes on Bulletproof Radio today to discuss what its like to get back in the ring, fighting through adversity, filming his new documentary, training and injuries. Enjoy the show! David Waknine is the founder of Hollywood Fight Club Productions and Pinocchio’s Playhouse. He is a former boxer and one of the finalists in the Golden Gloves Boxing tournament. He has written and directed over 150 plays, commercials, and short films. He is currently the director and star of his upcoming documentary, One More Round, a documentary about a journey of a former Golden Gloves finalist returning to the ring and challenges he faces like injury, and weight loss. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Huhti 201536min

Daniel Pardi: Date Rape Drugs, Napping, & Jet Lag - #208

Daniel Pardi: Date Rape Drugs, Napping, & Jet Lag - #208

Why you should listen – Daniel Pardi comes on Bulletproof Radio today to discuss jet lag, sleep disorders like insomnia and narcolepsy, date rape drugs and the science of napping. Enjoy the show! Daniel Pardi is a researcher in Psychiatry and Behavioral Sciences. He developed the Loop Model to Sustain Health Behaviors and created humanOS.me and dansplan.com to educate people on how to facilitate optimal health behaviors. He has consulted with the Naval Special Warfare department on how to make fighters more vigilant in combat and non-combat conditions, and has given keynote addresses at events like Paleo f(x). See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Huhti 20151h 3min

Bulletproof Radio Q&A - #207

Bulletproof Radio Q&A - #207

Why you should listen – On this episode of Bulletproof Radio, we have carefully selected the best questions from Facebook, Twitter, and the Bulletproof® Forums for another awesome Q&A. Hear Dave answer questions with Zak about Diet Coke, moldy homes, nootropics and a lot of other great questions that our listeners have submitted to Bulletproof Radio. This episode has a ton of great information all condensed into one, enjoy! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Maalis 201542min

Dr. Tami Mergalia: Testosterone Supplementation, Skinny Fat, & Adrenal Fatigue - #206

Dr. Tami Mergalia: Testosterone Supplementation, Skinny Fat, & Adrenal Fatigue - #206

Dr. Tami Mergalia is a double board certified physician in Aesthetic Medicine, Integrative & Natural Medicine, and the owner of Vitality Medical Clinic in Seattle. She is a faculty member of the American Academy of Aesthetic Medicine and a national trainer in Medicis. She has travelled the world as a trainer in advanced injection techniques and lecturing on aesthetics and bioidentical hormones for men and women. She has been featured in Shape Magazine, Fox News and her new book, The Hormone Secret, lays out the secret weapons for anti aging, weight loss, and increased vitality.   Why you should listen – Dr. Tami Mergalia comes on Bulletproof Radio to discuss adrenal fatigue, the importance of your circadian rhythm, what it means to be skinny fat, and the pros and cons of testosterone supplementation. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Maalis 201546min

Wendy Myers: Heavy Metal Toxicity, Mineral Power, & Coffee Enemas – #205

Wendy Myers: Heavy Metal Toxicity, Mineral Power, & Coffee Enemas – #205

Wendy Myers is the Founder and Chief Eating Officer of the Liveto110 Blog and host of the Liveto110 podcast show. She is a certified holistic health and nutrition coach, a functional diagnostic nutritionist, and creator of Mineral Power program that utilizes hair mineral analysis to help clients fix mineral deficiencies for a broad spectrum of health conditions. She specializes in using alternative detoxification treatments and diet to help people live healthier lifestyles and is currently working on her next book, The Modern Paleo Survival Guide. Why you should listen – Wendy comes on Bulletproof Radio to discuss how to detox heavy metals, hair mineral test analysis, coffee enemas, and living to 110. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Maalis 201544min

Rocco Dispirito: Cook Your Butt Off - #204

Rocco Dispirito: Cook Your Butt Off - #204

Rocco Dispirito is a James Beard award-winning chef and author of eleven books, including the New York Times Best-selling Now Eat This!, The Pound a Day Diet, and his newest book, Cook Your Butt Off. He was named Food & Wine’s Best New Chef, was the first chef to grace the cover of Gourmet as “America’s Most Exciting Young Chef”, and opened the 3-star Union Pacific Restaurant in New York City. Why you should listen –   Rocco comes on Bulletproof Radio to discuss modern cooking, food cravings, activity tracking in the kitchen, and why food should do more than just taste good. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Maalis 201558min

Marc Goodman: Cyber Security, Transhumanism, & Future Crimes  - #203

Marc Goodman: Cyber Security, Transhumanism, & Future Crimes - #203

Why you should listen – Marc comes on Bulletproof Radio to discuss transhumanism, the dangers of technology, cyber security precautions you can take to protect yourself from cyber threats and cyber crime, and the story behind The Silk Road. Enjoy the show! Marc Goodman is the founder of the Future Crimes Institute and currently serves as the Chair for Policy, Law and Ethics at the Silicon Valley’s Singularity University. Over the past 20 years, Marc has worked with Interpol, the United Nations’ Counterterrorism Task Force, NATO, and the US Government as a global strategist and consultant about the impact of technology on security, business, and international affairs. He has also worked as a police officer and undercover investigator, and has been published in business and technology publications such as The Economist, the Harvard Business Review, and Forbes, and been featured on a myriad of news networks, including CNN, ABC, NBC, BBC, and Fox News. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Maalis 201557min

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