The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld  : 1265

The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld : 1265

For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging?

In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most probiotics fail—and how one company’s scientifically validated approach could redefine your gut, brain, immune system, and even your metabolism.

You’ll learn how dysbiosis may be wrecking your brain without you knowing it, why your probiotic likely died in your stomach acid, and the secret to rebooting your microbiome after antibiotics, GLP-1 drugs, or years of toxic exposure. This isn’t just about digestion—your gut controls your cravings, energy, sleep, mood, and aging trajectory.

So what’s the one upgrade that can actually reset your gut… for good?

What You’ll Learn in This Episode:

• Why your gut—not your brain—is making most of your decisions

• How 93% of probiotics on the market fail before they reach your intestines

• The “AB 10” protocol that rebuilds your gut after antibiotics or SIBO

• What GLP-1 weight-loss drugs are doing to your microbiome (and how to stop it)

• The shocking gut–brain–heart axis connection you’ve never heard of

• Why inflammation, brain fog, and mood swings may start with leaky gut

• Which probiotic strains are clinically proven to improve cognition and mood

• What to do if you want to eat gluten again—or survive American wheat

• How a fermented papaya concentrate could replace your acid reflux meds

• Why optimizing your gut could extend your lifespan by 40%


***Get 20% off your next purchase by going to https://omnibioticlife.com/pages/dave-asprey/ or omnibioticlife.com/dave***

SPONSORS

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.

Resources:

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

OMNi-BiOTiC's Instagramhttps://www.instagram.com/fatty15/

OMNi-BiOTiC's Website: https://omnibioticlife.com/

2025 Biohacking Conference: https://biohackingconference.com/2025

Danger Coffee: https://dangercoffee.com

Dave Asprey’s Website: https://daveasprey.com

Dave Asprey’s Linktree: https://linktr.ee/daveasprey

Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

Own an Upgrade Labs: https://ownanupgradelabs.com

Upgrade Labs: https://upgradelabs.com

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com


Timestamps:

00:00 – Trailer

03:15 – Intro

05:05 – Probiotics, Prebiotics, and Postbiotics Explained

08:21 – The Importance of Delivery Mechanisms

17:36 – Addressing SIBO and Gut Health Protocols

31:55 – The Impact of GLP-1 Drugs on Gut Health

39:26 – The Role of Gut Bacteria in Hunger and Fasting

40:01 – Painkillers and Gut Health: A Personal Experience

40:51 – The Dangers of Proton Pump Inhibitors

42:00 – The Importance of Stomach Acid

44:55 – Probiotics for Chronic Conditions

48:38 – The Impact of Glyphosate on Gut Health

57:04 – Alcohol and Gut Bacteria

01:02:01 – New Solutions for Acid Reflux

01:07:57 – The Future of Gut Health and Longevity

01:11:33 – Conclusion and Special Offer

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1432)

A Crash Course in How to Build Radical Confidence – Lisa Bilyeu : 936

A Crash Course in How to Build Radical Confidence – Lisa Bilyeu : 936

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Track Blood Glucose: https://www.levelshealth.com/DAVE, sign up for the Beta groupKickstart Autophagy: https://timelinenutrition.com/DAVE, use the code ASPREY10 to get 10% off any planMattress Temperature Tech: https://www.eightsleep.com/dave, use code DAVE to save $250 on the Pod ProIN THIS EPISODE OF THE HUMAN UPGRADE™... …you’ll learn that to be a high performer, you’ve got to have radical confidence to achieve whatever goals you set for yourself. Today’s guest, Lisa Bilyeu, explains how real confidence is an inside job, not something you gain from outside validation. When Lisa co-founded Quest Nutrition, she was a self-professed housewife boxing protein bars in her living room. The company grew 57,000 percent in its first three years and became a billion-dollar brand. Her learning curve was steep and fast and filled with things she didn’t know how to do—yet. She went on to co-found (with her husband, Tom Bilyeu) and serve as president of Impact Theory Studios. It’s a digital-first studio that produces entertaining original content focusing on themes of empowerment. That content has been viewed over half a billion times by a global audience.Lisa oversees in-house development of projects focused on female-driven content for multiple platforms. She hosts the digital series, “Women of Impact.”In her first book, “Radical Confidence: 10 No BS Lessons on Becoming the Hero of Your Own Life,” she shares her journey from a housewife to successful entrepreneur with relatable lessons, anecdotes, and lots of humor.She explains how the “Purgatory of the Mundane” is even more dangerous than hitting rock bottom. She dishes tough love for those of you who are stuck in mind loops that hold you back.From ditching the fairy tale to getting off the couch to putting on goggles when the shit hits the fan, Lisa’s got realistic tips to get you moving. An important part of that momentum is setting boundaries: material, physical, and mental and emotional. She shows you exactly how.She also suggests a fresh perspective on a few things that can help you build “radical” confidence:Manage the voice in your headSet clear boundariesLearn from your mistakesKeep your goals top of mindMaintain self-awareness around your emotions and triggersSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Mai 20221h 11min

Upgrade Spotlight: Find Your Footing in Minimalist Footwear – Xero Shoes : 935

Upgrade Spotlight: Find Your Footing in Minimalist Footwear – Xero Shoes : 935

IN THIS EPISODE OF THE HUMAN UPGRADE™... …you’re listening to a new Upgrade Spotlight series based on what you told me you wanted to hear on this podcast. On one Friday each month, these shorter episodes will feature guests who’ll get right into useful information in a Q&A style. You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful tools and technologies that allow you to change your biology and the environment around you. Introducing Xero Shoes! During this Upgrade Spotlight, you’ll learn how minimalist footwear reduces injury, improves foot strength and supports healthy feet. You’ll learn that getting grounded is a good thing.Today’s guest—serial entrepreneur Steven Sashen—is a competitive sprinter. He knows the mechanics of human feet. He also knows what it feels like to move in shoes that suck. So, he and his wife, Lena Phoenix, founded the footwear company Xero Shoes. They ran headlong into shoe history and shoe science to intentionally create “a MOVEMENT movement” of people with happy, healthy, strong feet in addictively comfortable footwear. “A quarter of the bones and joints of your whole body are in your feet and ankles,” Steven says. “They're supposed to bend and move and flex just like any other joint. If you're wearing shoes that don't let them do that, that function tries unsuccessfully to move into your ankle, your knee, your hip and your back joints. Those joints aren't built for those micro motions that keep you balanced, that give you agility and mobility.”Your feet, and by design the rest of your body, know something’s off with cushioned shoes. So does Steven.“The value of natural movement, the importance of foot health, and all the things that relate to foot health got me going,” he says. “But what really catalyzed it was discovering that what the footwear industry has been doing for 50 years is lying to people– selling people on ideas that they know don't work, but they can't pull back. They can't tell a different story, because they've been promoting this story for so long about arch support, motion control, padding, cushioning, etc.” Research published by the American College of Sports Medicine in 2021, “Stepping Back to Minimal Footwear: Applications Across the Lifespan," showed that minimal footwear leads to improved musculoskeletal health across your lifetime. “It’s all about natural motion,” Steven explains. “Our ancestors didn't have a problem being on their feet all day, every day. It wasn't because they're different from us, it was just that they got used to using their feet correctly. We can still do that any day, anytime, any of age.”CHECK OUT XERO SHOES and the 5,000-MILE SOLE WARRANTY! U.S.: https://xeroshoes.com and EU: https://xeroshoes.euSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Mai 202246min

How to Double Your Energy – Ari Whitten : 934

How to Double Your Energy – Ari Whitten : 934

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Complete Spectrum Hemp + Chinese Herbs: https://radicalrootsherbs.com/DAVE, use code DAVE to get 10% off Meat Sticks, Apple Cider Vinegar and More Good Stuff: https://paleovalley.com/DAVE, use code DAVE to get 15% off your first orderBiostack for High Performance: https://vatellia.com, use code DAVE2022 to save 10% or subscribe and save 15% + receive a free bottle of Kale BusterIN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll find out why you’re tired, how to fix it and ways to increase your energy. Fatigue is a hidden epidemic, with chronic fatigue syndrome being the most severe end, but most people (in the U.S.) are experiencing some level of being flat-out tired as hell.Guest Ari Whitten, Ph.D. (Cand.), CES, PES, says that as a culture, we have normalized fatigue. In his newest book, “EAT FOR ENERGY: How to Beat Fatigue, Supercharge Your Mitochondria, and Unlock All-Day Energy,” he explains that 5.4 million adults in the U.S. have been diagnosed with chronic fatigue syndrome (the most severe case of fatigue). However, the true fatigue epidemic affects 50 to 100 times more people.This episode’s discussion gets right into the role of mitochondria in human energy. Ari’s research (420 citations in “Eat for Energy”!] is clear. The cause of fatigue is mitochondrial dysfunction, he says. And the biggest factors that affect your mitochondria include:Circadian rhythm dysregulation and poor sleep Carrying too much body fat and too little muscle mass Poor gut and microbiome health Blood sugar dysregulation Nutritional toxicities and deficiencies Neurotransmitter and hormone imbalances So what can you do to increase your energy currency? A lot, as it turns out. When you understand factors like resilience, cell defense, nutrition and supplementation, you’re on your way to better energy. In this conversation, you’ll learn:what’s causing the dysfunction in your mitochondria and how you can repair these critical energy cells. strategies that will double your energy levels. 7 top supplements (and more) that help get your mitochondria back on the energy track. Ari has been studying and teaching natural health science for more than 25 years. He went through his own battle with chronic fatigue that inspired his obsession with energy. For the past seven years, he's focused specifically on improving human energy. His education and work in this area touches on critical aspects of human health from nutrition to physical training, to light science, to psychology, and more. He created The Energy Blueprint science-based lifestyle programs that target brain energy and mitochondria. He also hosts The Energy Blueprint podcast that features world-wide experts on the subject of understanding fatigue and how to get more energy. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Mai 20221h 1min

Relieve Your Back Pain in 4 Steps – Dr. Marcella Madera : 933

Relieve Your Back Pain in 4 Steps – Dr. Marcella Madera : 933

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Sleep Better on Natural Memory Foam: https://myessentia.com, use code DAVEVIP to get an exclusive discountMust-Have Magnesium: https://magbreakthrough.com/DAVE, use code DAVE10 to get a 10% discountControl Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentIN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll meet a holistic neurosurgeon who’s evolving spine care away from cutting. Dr. Marcella Madera’s integrative approaches to spine problems pair science with holistic healing modalities. This means way better healing for you.Dr. Madera’s innovations in spine treatments include the “Aqua Method,” where photobiomodulated platelet rich plasma meets functional tissue mobilization and movement. You’re going to get exciting new information about this effective form of regenerative medicine and find out if this treatment may be right for you. “It's a very nuanced discussion,” says Dr. Madera. “It's very patient specific. It's very injury specific.”“The term Aqua really gives a description of what we're trying to create in the body and that is more fluidity,” she explains. “And also, water, aqua, is pure. It’s intense at times, depending on the form. And it is soothing at times, depending on the form. And that is how our treatment goes.”Dr. Madera’s four-part system includes: Reveal, Restore, Revitalize, Revel. You could benefit whether you have an old or new injury, or chronic pain.During this episode, she explains how each part is interconnected and helps you heal your spine, or even knee, problems. The Aqua Method’s three-day immersive experience includes a full team of experts focused on your biology, your energy and your state of mind.Dr. Madera, a board-certified neurosurgeon, trained extensively in conventional medicine. Her expertise in spine care includes surgical treatments, approaches, and techniques for degenerative spine disease, spine tumors, and degenerative deformity. She started a private practice in in Austin, Texas where she combines her technical spine care with stem cell treatments and holistic modalities like herbs, energy modalities, Chinese healing practices, autogenic training and diet modification.SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Get a $1,000 discount on the Aqua Method at Austin Integrative Spine in Austin, Texas. Call the clinic at 512-817-4600 and mention discount code DAVEASPREY.More about Dr. Marcella Madera: She’s experienced in open surgery, minimally invasive surgery, endoscopic spine surgery, and regenerative/stem cell procedures. She’s been an assistant professor of Surgery at the University of Texas at Austin Dell Medical School. She also travelled throughout Europe and the U.S. to learn progressive endoscopic techniques and regenerative medicine practices. She completed a Spine Fellowship and faculty instructorship at Johns Hopkins School of Medicine.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Mai 20221h 6min

Mini-Episode: Cool Facts Friday #22

Mini-Episode: Cool Facts Friday #22

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.GlyNAC (glycine and N-acetylcysteine) can correct glutathione deficiency, oxidative stress, mitochondrial dysfunction and mitophagy abnormalities to help you live longer.Moms and dads think — and react — differently to newborn baby smells.Clock and Cycle factors control circadian rhythm and protect your eyes as you age. Oleic acid produced in the brain helps regulate memory, learning, and mood; promotes neurogenesis; and increases cell proliferation.EPISODE SPONSOR: The Eng3 NanoVi device helps repair oxidative stress damage and support the body’s natural repair mechanisms. https://eng3corp.com/DAVE/. Learn more: The Anti-Aging Science Behind the NanoVi Device – Rowena Gates & Hans Eng – #416.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Apr 202215min

Great Relationships Start with You & Hard Truths – Gary John Bishop : 932

Great Relationships Start with You & Hard Truths – Gary John Bishop : 932

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Nature’s Nootropic: https://trukava.com, use code DAVE15 to get 15% offNAD+ for Brain Health: https://innovativemedicine.com/DAVE and save 20%Support Immune & Digestive Health: https://justthrivehealth.com, use code ASPREY to get 15% offIN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll learn that one of the major life upgrades you can make includes your relationships. Personal development expert Gary John Bishop doesn’t buy into mainstream notions of what makes a happy relationship. Not 50/50 effort, not compromise, not molding yourself into what your partner wants. It’s just you and some hard truths.What this episode is not about;Blame or providing communication tipsHow to change or cope with your partner and personality types Healing past trauma or understanding fear of commitment Instead, you’ll get the ingredients to creating a real, lasting and profound connection with another human being.“There's some, again, cold truths that you have to face and then really have to start to take on,” he says, “but in a way that it's not always going to go your way. You're not always going to get this thing flowing the way you would want it to go, but your job is to keep bringing yourself to this phenomenon in a way that's consistent with you, who you are, what you're about. And powerfully managing all that you might do to undermine it.”Gary, the New York Times bestselling author of the Unfu*k book series, uses an “urban philosophy” approach that’s both simple and enlightening. In his latest book, “LOVE UNFU*kED Getting Your Relationship Sh!t Together,” he puts the focus on relationships. “The quality of your relationships dictates the quality of your life,” he says in “LOVE UNFU*kED.” This conversation gets right to the heart of what you can do to make changes that stick in all areas of your life.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Apr 20221h 6min

WetSpace, Crypto & Taking on Big Tech – Allie Rae : 931

WetSpace, Crypto & Taking on Big Tech – Allie Rae : 931

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Gifts for Mother’s Day – or Any Day: Give the sensation of a hug, deep relaxation and better sleep: https://balooliving.com/dave, use code DAVE for a special discountHealth Upgrades with Custom Lab Testing and Your Own Data: https://get-base.com/DAVE, use code DAVE to get 20% off your first month of membershipMeat Sticks, Apple Cider Vinegar and More Good Stuff: https://paleovalley.com/DAVE, use code DAVE to get 15% off your first orderIN THIS EPISODE OF THE HUMAN UPGRADE™...You’ll be part of a candid conversation about choice and freedom. And, why it’s important to be able to make a living in your chosen line of work without restriction or judgment. That’s just part of being a better-performing human.Guest Allie Rae, a wife, mother, retired nurse and Navy veteran, shares her unusual entrepreneurial journey within the adult sex entertainment industry. It may be a different topic than you expect on this show, but it’s a look at innovation opening up alternative ways of doing business outside restrictive Big Tech.She’s CEO of a brand-new online adult platform called WetSpace. You may have heard about or know of the OnlyFans platform. WetSpace is similar, but not direct competition. Allie Rae saw a problem with payment systems and banking restrictions and set out to find a solution.“At this point, this is no longer a hobby, it's a business for me,” Allie Says. “And as any business in any industry, you want to protect your business and provide stability and have long-term prosperity.”We get into some cool topics:Why Allie Rae created WetSpace;How cryptocurrency fits into her plans;The influence of Big Tech; andHow advocacy—not regulation—can guide the growth of the adult sex industry.Today’s show looks at personal choice and freedom—both yours and other people’s. It challenges stigma, advocates for better systems of work, and supports creativity and business acumen.it's important that we think about both sex, because that's one of those big things that nourishes us, and also think about what's going on in the world around us, that environment that controls your biology.It matters that you’re able to choose what to do to and with your body, your energy, and your time. You get to choose to live your values—and so does everyone else. Even if you don’t agree. Being kind and respectful goes a long way in creating communities that allow you to be the highest performing human you want to be.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Apr 20221h 9min

Hacking Weight Loss Resistance – Interventions With Dave – Diane Closser : 930

Hacking Weight Loss Resistance – Interventions With Dave – Diane Closser : 930

IN THIS EPISODE OF THE HUMAN UPGRADE™...… Dave talks with Diane Closser about weight loss resistance. You’ll find out how unexpected and insidious factors–both internal and external–may be affecting your body systems. That dysregulation can cause your body to hold onto excess weight. Diane Closser knows a lot about chemicals. She’s a chemist by profession and works as a Certified Lubrication Specialist and Certified Reliability Leader at a Division of General Motors.She also has a personal history of mold and heavy metal exposure, e.g., bought fixer-upper 1972 house, played with Mercury as a kid, worked as a wet bench chemist analyzing heavy metal production products, and worked in tire industry.She’s been on a journey to wellness for several years that’s included a search for real health solutions. There have been some wins: In 2020, she became particularly sensitive to chemicals, perfume, and laundry detergent. She says that ozone therapy cured her of her sensitivity and reversed her autoimmunity. And some setbacks: Her health deteriorated when husband was diagnosed with a brain tumor in 2011.She also had her house treated with Chlorine dioxide; did low-dose allergen therapy and low-dose immunotherapy; and completed chelation therapy. Through it all, she’s experienced a frustrating weight loss resistance. She says she’s “been on every diet and med known to man” since her teenage years. Now in her mid-50s, she’s looking forward to a retirement that includes sailing and bringing tap, jazz, and ballet classes to senior citizens around the country. She wants to improve her health and have the energy to make her plans a reality.In this “Interventions With Dave” episode, Dave and Diane look at her health concerns through a new lens. They examine possible causes of her inability to shed excess weight and discuss actionable next steps. Calorie counting Eating too little Environmental toxinsChemical sensitivitiesMold OzoneHistamineMast cellsMetal toxicity and chelation therapyBrain fogThyroidTestosterone in femalesMycotoxinsDetox pathwaysCollagenNote: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.Listen to the Interventions With Dave series and don’t miss the “Links & Resources” section below for specific information. Hacking Thyroid, Autoimmunity & Aging #918Hacking Inflammation #915Hacking Your Gut Microbiome #908Hacking Menopausal Weight Gain #904Hacking Eyesight #895See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Apr 202243min

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