Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1412)

Bonus: Client Review with Jonathan Kos

Bonus: Client Review with Jonathan Kos

Jonathan Kos is an IT professional and a recent follower of the Bulletproof Diet.  He is a 44 year old IT professional . At 6' 3" and a former college athlete that played football, competitive ice hockey up until the age of 25 he was an extremely fit 220 lbs and my coaches wanted me up to 275 or so to play the defensive line so I was eating literally non stop to put weight on. After college he dropped down to around 200 lbs and eventually settled at for me was a healthy 235.  As he got older and more settled in his job, his weight climbed and he couldn’t keep his weight in check with exercise alone and he started to have to diet he was up to 300 lbs and was exercising more that ever but the weight didn’t come off. After he met his wife, exercise was out the window, a carb heavy diet was in, and his weight ballooned up to 365lbs. He was about to give up until he heard Tait Fletcher on Joe Rogan's podcast mentioning Bulletproof ® Coffee and he gave it a shot. He lost 45lbs in 45 days, and is here to share his experience with you.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Jun 201311min

#44: Salt and self-experimentation with Greg Pomerantz

#44: Salt and self-experimentation with Greg Pomerantz

For Greg Pomerantz everything is a science experiment. He takes citizen science to a personal level by biohacking his blood pressure and detailing his data. He blogged about his self-experiment research on salt clarifying some concerns he had about salt’s effect on the body. He determined what his salt type is, either one is salt sensitive, or one that isn’t affected much by increases in salt. He discusses how to do that in today’s podcast. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Jun 201337min

#43: Kelly Starrett, Mobility and Performance

#43: Kelly Starrett, Mobility and Performance

Coach Kelly Starrett received his Doctor of Physical Therapy in 2007 from Samuel Merritt College in Oakland, California. He currently runs his own physical therapy practice at San Francisco CrossFit—one of the first 50 CrossFit affiliates—and focuses on performance-based Orthopedic Sports Medicine with an emphasis on returning athletes to elite level sport and performance. His clients see exceptional results from his progressive blend of manual physical therapy and strength training. Since 2009, Kelly has been traveling the country teaching his "Movement, Mobility & Maintenance Course" in an effort to spread his message that good mobility and proper movement are the keys to good performance and that all humans should be able to perform this basic maintenance on themselves. Kelly's clients have included Olympic gold-medalists, Tour de France cyclists, world-class extreme skiers and X-Games medalists, dancers with Smuin, San Francisco, and Sacramento Ballet Companies, military personnel, and competitive age-division athletes. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Mai 201350min

#42: Alderspring's Glenn Elzinga, Grass-Fed Beef and a Bulletproof Protein

#42: Alderspring's Glenn Elzinga, Grass-Fed Beef and a Bulletproof Protein

With training in forestry and forest ecology, Glenn Elzinga began his forestry career in Maine. In the mid 1980s, he moved to Salmon, Idaho where he worked as District Forester for the Salmon BLM for over a decade. As his family began to grow, he realized he wanted a better way to raise kids than leaving them for work all day. So began his current career in ranching. After ranching for 17 years, Glenn's cattle herd has grown from 7 head to over 600. He keeps his hand in forestry by working with his wife, Caryl, on consulting projects and by horse-logging occasionally with his two Belgian mares, Pet and Pat. He hopes to train his new draft Suffolk geldings, Red and Snap, to log as well. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Mai 201350min

#41: Jason Nunnelley, Self Tracking

#41: Jason Nunnelley, Self Tracking

Jason Nunnelley’s work is focused on application and systems development. After his first company sold in 2000, he spent his time helping small business capitalize on Internet technologies. He is presently dedicated to dosIQ, Inc., a Wellness Journal and set of apps designed to make self-tracking and health monitoring simple for anyone. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Apr 201358min

#40: Dan John, Brains & Brawn

#40: Dan John, Brains & Brawn

Dan John has spent his life with one foot in the world of lifting and throwing, and the other foot in academia. An All-American discus thrower, Dan has also competed at the highest levels of Olympic lifting, Highland Games and the Weight Pentathlon, an event in which he holds the American record. Dan spends his work life blending weekly workshops and lectures with full-time writing, and is also an online religious studies instructor for Columbia College of Missouri. As a Fulbright Scholar, he toured the Middle East exploring the foundations of religious education systems. His books, on weightlifting, include Intervention, Never Let Go, Mass Made Simple and Easy Strength, written with Pavel Tsatsouline as well as From Dad, To Grad. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Mar 201358min

#39: Hormone Alchemy (+ Why Hard Data is HOT)... How to Amplify the Positive Neuro-hormonal Dashboard with Dr. Sara Gottfried MD

#39: Hormone Alchemy (+ Why Hard Data is HOT)... How to Amplify the Positive Neuro-hormonal Dashboard with Dr. Sara Gottfried MD

Dr. Sara Gottfried is a Harvard doc, biohacker, and yoga-powered champion of your health, happiness and hormonal equilibrium. She’s also seen 20,000 patients in the past 20 years and applied her training as a MIT bioengineer to how women and men can leverage the upstream and downstream mediators to create natural hormone balance with next gen medicine, and wrote a book about it, called The Hormone Cure: Reclaim Balance, Sleep, Sex Drive, and Vitality Naturally with The Gottfried Protocol (Simon & Schuster, 3/12/13) She biohacked her own happy hormones and happy brain chemicals as a 30-something stress case battling McMedicine, PMS, and low sex drive. She was offered Prozac and a birth control pill for her misery by her primary care physician, and that was a defining moment that allowed her to step from her darkest hour into the grace of biohacking bliss. The main culprit: CORTISOL. It took her 4 weeks to get her crazy-high cortisol down to the Goldilocks position of not too high and not too low, and she applied that learning and refined her protocol on her next 10,000 patients over the next 10 years. Results were staggering: Dr. Sara could neutralize cortisol, what she calls the “bad-boyfriend” hormone in 1 minute. She reversed insulin resistance in 48 hours. She got estrogen back into it’s rightful place, and thyroid, inside of 2 weeks. She believes knowledge is power, science is sexy... and, oh yes, actionable needle-moving solutions are hot. Listen in for our dialogue about cutting-edge science, and crazy-lovin’ solutions -- for men and women. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Mar 20131h 4min

#38: Mark Divine, Bulletproof Warrior and SEALFIT's founder

#38: Mark Divine, Bulletproof Warrior and SEALFIT's founder

Mark Divine is from upstate New York and did his formal undergraduate education at Colgate University. His years at Colgate University were focused on the athletic endeavors of competitive swimming, rowing and triathlon racing. Mark pursued a Ph.D. in Leadership at the University of San Diego and served as an Adjunct Professor of Leadership in their undergraduate school. The Doctorate was interrupted by a one-year recall to active duty for Operation Iraqi Freedom. The recall took him to Baghdad in 2004 with SEAL Team One to conduct a special project studying the future role of the USMC in the Special Operations Command. Upon his return home he left USD to focus on developing SEALFIT and put his Unbeatable Mind training philosophy to work on a new generation of Special Ops candidates. You will learn all about this amazing program and more in this exclusive interview! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Mar 201355min

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