Biohacking News Weekly Update : 1363

Biohacking News Weekly Update : 1363

This episode covers:


• Cocoa Extract Cuts Heart Deaths

A massive COSMOS trial found that older adults taking high flavanol cocoa extract daily saw a 27 percent reduction in cardiovascular deaths along with drops in inflammation markers like HSCRP. Women showed unique anti inflammatory cytokine shifts, pointing to a broader longevity effect. Dave explains why cocoa extract is becoming a foundational nutrient for vascular health rather than a dessert ingredient.

Source: https://www.sciencedaily.com/releases/2025/09/250926135957.htm


• AI Stethoscope for Home Diagnostics

Lapsi Health’s Keikku 2.0 just became the first FDA cleared AI powered digital stethoscope for both clinicians and home users. It records heart and lung sounds, analyzes them instantly, and flags early warning signs before symptoms appear. Dave breaks down why tools like this move you from reactive to predictive medicine and why they belong in every quantified self toolkit.

Source: https://www.prnewswire.com/news-releases/lapsi-health-unveils-keikku-2-0-worlds-first-fda-cleared-digital-stethoscope-with-integrated-ai-scribe-302585083.html?utm_source=chatgpt.com


• Beef Organ Supplements Surge

Beef organ supplements have exploded more than 8,000 percent this year, driven largely by women reporting improvements in energy, hormones, mood, and skin. Liver, kidney, and heart deliver vitamin A, heme iron, B12, copper, and choline that modern diets often lack. Dave covers sourcing concerns, purity standards, and why this shift reflects a move from fear based nutrition to evolutionary nutrition.

Source: https://www.verywellhealth.com/beef-organ-supplement-11710185?utm_source=chatgpt.com


• Spirulina for Collagen and DNA Protection

New research highlights spirulina’s ability to support collagen production, reduce oxidative stress, protect DNA, and improve glucose and lipid balance. It is becoming a staple of eco focused anti aging routines and is driving the viral green stacking trend with chlorella and chlorophyll. Dave explains why spirulina functions as a clean daily defense against oxidative stress.

Source: https://www.news-medical.net/news/20250707/Is-Spirulina-the-Next-Anti-Aging-Superfood.aspx


• Health Data Privacy Reform

A new Senate bill aims to extend HIPAA level protections to wearables, genomic tools, glucose monitors, and wellness apps. The goal is to give users control over who sees their biometrics, how they are stored, and whether they can be sold. Dave outlines why this matters for anyone using Oura, Whoop, CGMs, or genetic testing and why your biology should belong to you and not the cloud.

Source: https://natlawreview.com/article/federal-healthcare-update-november-7-2025


All source links provided for easy reference to the original reporting and research above.


This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: cocoa extract, flavanols, heart health, nitric oxide pathways, COSMOS trial, AI stethoscope, digital diagnostics, Keikku device, predictive health tech, beef organ supplements, women’s hormonal health, nutrient dense foods, ancestral nutrition, spirulina benefits, collagen support, oxidative stress defense, green stacking, chlorella pairing, DNA protection, wearable privacy laws, HIPAA reform, biometric data rights, longevity news, biohacking updates


Thank you to our sponsors!


Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 – Intro

0:19 – Cocoa Extract & Heart Health

1:52 – AI Digital Stethoscope

3:01 – Beef Organ Supplements

4:24 – Spirulina for Longevity

5:42 – Substack Announcement

6:53 – Health Data Privacy Reform

8:23 – Weekly Upgrade Protocol

9:46 – Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1427)

The Expert In Your Face: Youthful Skin Without Surgery – Dr. Anthony Youn : 1120

The Expert In Your Face: Youthful Skin Without Surgery – Dr. Anthony Youn : 1120

Dr. Anthony Youn, aka “America’s Holistic Plastic Surgeon,” is an expert in your face. He joins us to answer some burning questions… Can plastic surgery actually be holistic? Can you turn back the clock without going under the knife? And… What work should I get done to my face? Today, we’re talking all about how to hack your face and save your skin. Dr. Youn is a nationally-recognized, board-certified plastic surgeon. He’s the most followed plastic surgeon on social media and a TikTok star. He’s the author of The Age Fix, In Stitches, and Playing God. His new book, Younger For Life, is a complete holistic guide to anti-aging using a process he coined called Autojuvenation. In today’s episode, we get into what Autojuvenation is, and how it helps you look younger without surgery—a surgeon who wants to help you avoid surgery! We talk about blending biohacking and cosmetics, natural vs. medical-grade skincare, collagen peptides, treating hair loss, and whether sunscreen causes or prevents cancer. Dr. Youn also tells us the dumbest things that both men and women do to their faces—and how to avoid them. Let’s face it, many of us want to look younger. This conversation is a fascinating look at how to approach aesthetics from a biohacker’s perspective. (00:01:55) Is There Such Thing As Holistic Plastic Surgery?(00:05:12) Natural vs. Medical-Grade Skincare(00:09:36) Holistic Alternatives That Traditional Physicians Don’t Know(00:16:47) Does Topical Collagen Work?(00:19:45) What Cosmetic Work Should Dave Have Done?(00:25:20) Blending Biohacking & Cosmetics(00:30:38) The Dumbest Things Men Do to Their Skin(00:35:37) Is Sunscreen Preventing or Causing Cancer?(00:38:33) The Dumbest Things Women Do to Their Skin(00:43:54) The Hair-Raising Effects of Hair Loss(00:52:35) Additional Skin Biohacks from a ProSponsors:Tru Kava https://trukava.com/ use code Dave15One Skin: https://www.oneskin.co/ use code Upgrade15ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: dryoun.comPre-order: Younger For Life (over $100 value of free bonuses)TikTok: @doctoryoun Instagram: @tonyyounmdYouTube: @DoctorYounPodcast: The Holistic Plastic Surgery Show The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Jan 20241h

Urolithin A: The Miracle Compound - Dr. Dominic Denk : 1119

Urolithin A: The Miracle Compound - Dr. Dominic Denk : 1119

Get ready for this important download on a fascinating biohacking compound you haven’t heard me talk about before: Urolithin A. It’s a postbiotic that supports the mitochondria, and it’s backed by impressive studies on longevity, anti-cancer effects, cognitive function, and muscle strength. In fact, this compound has earned a place in my permanent stack—which you know isn’t easy to pull off.Today, I chat with Dr. Dominic Denk, who’s done some of the original research on Urolithin A and the company that makes it, Timeline Nutrition powered by Mitopure. Dr. Denk works as a physician in the Department of Internal Medicine at University Hospital Frankfurt. Dr. Denk breaks down what Urolithin A is and how it impacts aging and cancer prevention—answering questions on when, how, and why to take Mitopure—before we delve into the powers of mitochondria, how to have more energy production in your cells, and the relationship between energy production and cancer. We also talk T cells, autoimmunity, and inflammation. Plus, we get into the differences in healthcare and pharmaceutical overreach in the U.S. and Germany. Tune in to uncover the latest life-changing compound—and find out what it will do for your heaviest lift in the gym, your cognition before your next big meeting, and to reverse aging over time. (00:03:31) Understanding Urolithin A (00:08:43) Genetic vs. Mitochondrial Cancer (00:14:48) Getting to the Root of Autoimmunity (00:21:19) Strong Evidence on Muscle Strength (00:23:59) Does Cancer Hate Americans? (00:27:59) Why Do We Age? (00:31:35) The Best Studied Compound You’re Not Taking (00:33:02) Talking T Cells (00:36:22) Healthcare in Germany vs. The U.S. (00:43:31) Urolithin A & Hot/Cold Therapies (00:45:55) Tripling Down on mTOR (00:52:05) Are There Downsides to Urolithin A? ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Timeline Nutrition: timelinenutrition.com and use code DAVE to save 10%. After January 1st, 2024, TimelineNutrition.com/dave for 30% discount.Mitopure: mitopure.comX: @DomDenkMDLinkedin: Dr.med. Dominic Denk The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Des 202358min

How & Why You Age, And What It Takes To Be 'Young Forever' – Mark Hyman, M.D. - End of Year Best-Of Episode! : 1118

How & Why You Age, And What It Takes To Be 'Young Forever' – Mark Hyman, M.D. - End of Year Best-Of Episode! : 1118

In this special end-of-year "best of" episode, you'll learn the Top 10 hallmarks of aging, the role of functional medicine in restoring and reversing aging, and the many practical ways you can promote your own longevity.Mark Hyman, M.D., joins Dave in Austin to talk all things longevity. Driven by his desire for a healthier, longer life for himself and others, Dr. Mark immersed himself in the latest scientific research on aging and longevity. Through his findings, he realized that the body has an incredible built-in healing system that can be activated through understanding the emerging science of longevity. He also managed to reduce his biological age by 20 years effectively.He consistently tackles the topic of inflammation and its impact on aging—or “Inflammaging” as he calls it. “The body only has so many ways to say ouch,” Dr. Mark says. “You have pain. You have inflammation. You have certain things that happen that create all these symptoms, but there're these common roots. So, inflammation is this common root that seems to accelerate as we get older. So, we can measure biomarkers of inflammation that are highly predictive of mortality.”This conversation covers many components of aging, like metabolic flexibility and resilience, mTor, meat- and plant-based protein, nutrition, environmental allergies and food sensitivities, histamine, autophagy, fasting, DEXA scans, and much more!In his book, "Young Forever: The Secrets to Living Your Longest, Healthiest Life,” Dr. Mark:shares the knowledge of how to unlock the causes of accelerated aging and treat it as a reversible disease.gives you practical tips for daily habits that will increase your energy and performance.teaches you why you age and what it really takes to live a longer, more vibrant life.Watch this episode on YouTube! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Des 20231h 8min

Change Absolutely Everything With One Hack – Robert Waldinger, M.D. - End of Year Best-Of Episode! : 1117

Change Absolutely Everything With One Hack – Robert Waldinger, M.D. - End of Year Best-Of Episode! : 1117

In this episode of The Human Upgrade you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive.Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study: Social connections are really good for you. Loneliness kills.It’s the quality of your close relationships that matters.Good close relationships don’t just protect your body, they protect your brain.Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like:how relationships improve your physical, mental and emotional health. (More than you know!)how to evaluate the effect of your relationships on your well-being. (Don’t be dragged down.)what social fitness is and how to practice it. (Yes, it’s a flex.)ways to enliven and energize your relationships. (Energy totally matters.)why casual and work relationships matter more than you think. (A surprisingly big contribution.)Watch this episode on YouTube!Don’t Miss This! Dr. Waldinger’s TEDtalk about the study is one of TED’s Top 10 episodes and viewed more than 43 million times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Des 20231h 13min

The Equinox Effect: Innovating Fitness – Lavinia Errico : 1116

The Equinox Effect: Innovating Fitness – Lavinia Errico : 1116

This episode is a deep dive into the heart of modern fitness, led by one of its most influential figures. Joining me today is Lavinia Errico, the visionary co-founder of Equinox Fitness Clubs. Lavinia isn't just a pioneer in the fitness industry, she's a passionate advocate for a life that's healthier, more fulfilled, balanced, and brimming with joy. She's dedicated to helping others achieve these same goals, inspiring people to delve into self-awareness and embrace transformative journeys. With her belief in enjoying the journey and embracing the process, Lavinia has shaped not just her own life but the lives of countless others towards seeing, feeling, and living remarkable results.Today, you’ll hear about how Lavinia's career in fitness and biohacking began with the birth of the modern fitness movement and Equinox as she shares challenges and triumphs of starting a fitness revolution in 1980s New York. You’ll also learn about the unique ethos that set Equinox apart and how building a business with family shaped its upward trajectory.This conversation is threaded with insight into the life of an entrepreneur, the realities of being a CEO, and how Lavinia intuitively balanced her professional journey with motherhood. Lastly, you’ll get a taste of Lavinia's wellness rituals, her philosophy as a lifelong learner, and her exciting new chapter with MOVEJOY, aimed at creating a more stress-free, joyous workout experience for everyone. (00:01:41) Laying the Foundation of Equinox(00:10:44) Finding the Joy of Movement(00:18:56) Advice for Women in Business(00:24:51) The Honest Cost of Being an Entrepreneur & CEO(00:32:14) Wellness Rituals & Being a Student of Life(00:44:47) Introducing Move Joy(00:55:27) Shifting the Why Behind MovementResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: movejoy.lifeInstagram: @laviniajoyLinkedIn: Lavinia ErricoThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Des 20231h 4min

Reversing Age: The Quest for Immortality with Bryan Johnson : 1115

Reversing Age: The Quest for Immortality with Bryan Johnson : 1115

Today is a long-awaited show with none other than Bryan Johnson, an entrepreneur, venture capitalist, author, and professional rejuvenation athlete on a mission to discover the next evolution of humankind. While Bryan is well known in the longevity space, I’ve been a fan of his work for years because of his neuroscience background. Bryan started a company called Kernel, which makes devices that monitor and record brain activity. Kernel uses what I would call the most comprehensive way of looking at the human brain ever. He is the founder of OS Fund and Braintree, and he spearheads Project Blueprint, an anti-aging experiment where he’s spent multiple years and millions of dollars developing an algorithm to live longer. In today’s wide-ranging talk, we discuss the future of optimizing our brains with AI—delving into all things biohacking and longevity while exploring complicated questions like… Can you die of loneliness? And… Are your critics making you old?Plus, we talk testosterone—an often triggering topic, but an essential conversation. Bryan shares his perspective on why he would rather be respected by people in the 25th century than understood now. Stick around for his surprising takes on olive oil, body hair, and saunas. (00:59) Biohacking The Brain (05:34) Are Your Critics Making You Old?(12:52) What Makes Bryan Tick(20:09) The Longevity-Loneliness Connection (28:27) Accounting For Bio Individuality in Health Protocols (39:09) Does Having a Partner Help You Live Longer? (47:59) Olive Oil vs. Saturated Fats (54:39) Talking Testosterone (01:07:52) Expanding Consciousness with Psychedelics (01:12:06) Questions from the Live Audience Sponsor: Try Qualia NAD+ with an extra 15% off with code Dave15.Resources:Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: protocol.bryanjohnson.comKernel: kernel.comRead: Don’t Die by Zero Instagram: @bryanjohnson_ YouTube: Bryan Johnson Linkedin: Bryan Johnson The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Des 20231h 26min

From Michelin Stars to Mental Clarity: The Nootropic Revolution - Dan Freed : 1114

From Michelin Stars to Mental Clarity: The Nootropic Revolution - Dan Freed : 1114

Coming to you live from Austin, Texas, I can’t wait for you to meet Dan Freed—a man who’s journeyed from the hot kitchen of high-end cooking to the frontier of brain improvement. Dan’s the founder and CEO of Thesis, a company that's revolutionizing the way we think about our brain's potential, and his journey is one of resilience and innovation. Picture this… A kid struggling with focus throughout childhood, he drops out of high school and claws his way up in the ruthless restaurant industry to become a saucier in a three-star Michelin kitchen. But the real twist comes when Dan, grappling with burnout, stumbles upon cognitive performance supplements. This discovery didn't just change his mental game, it transformed his entire life. Fast forward through degrees from Yale and INSEAD, and you have the Dan that sits down for this interview—committed to helping others harness their brainpower to the fullest.We get into the nitty gritty of nootropics and the supplement industry, talking about how Dan's fight with burnout and learning challenges led to the birth of Thesis Nootropics. We share tips on adapting human biology to our modern world, discuss the thorny issues of regulation and quality in the supplement industry, and explain how Thesis uses a unique combined approach of customizing nootropics and expert support for their customers. We round it all off with a look at the remarkable, results-driven formulas that Thesis offers, and how focus is the key to unlocking our greatest potential. Dan's story is a living proof that sometimes, a couple of stumbles can lead to an incredible leap forward, thanks to some conscious action. That’s the kind of journey we all can learn something from.(00:02:14) How Burnout & Learning Challenges Inspired Thesis Nootropics(00:19:15) Is Using Nootropics Cheating?(00:25:37) Tips for Adapting Human Biology to the Modern World(00:32:33) How Thesis Is Customizing Nootropics(00:40:59) Tips for Supporting Your Body’s Homeostasis While Taking a Stimulant(00:46:33) Dave Rings the Alarm on Formulating With Vitamin B6(00:50:53) Regulation & Quality Concerns in the Supplement Industry(00:57:41) Key Ingredients in Thesis’ Clarity & Logic Formulas That Drive Real Results(01:04:28) Unlocking Your Potential Through the Power of FocusResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: takethesis.com and use code “Asprey” for a 10% off all Thesis products.Instagram: @takethesisFacebook: Take ThesisThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Des 20231h 12min

How Intermittent Fasting Works for Women! – Cynthia Thurlow, NP

How Intermittent Fasting Works for Women! – Cynthia Thurlow, NP

Cynthia Thurlow joins the show to talk about how intermittent fasting can help women change their body, metabolic system and brain function. She has tips for women at all stages: from active menstrual cycles to perimenopause to menopause.Cynthia is a Johns Hopkins-trained nurse practitioner and functional nutritionist founded and serves as CEO of Everyday Wellness Project. She holds a Master of Science degree in Nursing and Functional Nutrition certifications with advanced trainings in Endocrinology and Gastroenterology. Her career in healthcare includes nearly 20 years of emergency medicine and cardiology experience. She brings a broad perspective when working with women to improve the state of their health. “I really start from a foundational level talking to women about fasting,” Cynthia says. “It's really honoring our own unique physiology. It's leaning into that menstrual cycle. It's leaning into the lifestyle piece that so much of us forget to talk about with our patients, our sleep quality, stress management, anti-inflammatory nutrition, our exercise quality, our connection with nature, all of which are critically important.”She also addresses diet dogma that frustratingly persists, even with established and emerging science about the benefits of intermittent fasting.She tackles this outdated dogma (and a lot more!) in her new book, “Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.”“[Intermittent fasting] restores our intrinsic rhythms, burns fat, regenerates our health right down to the cellular level, and stabilizes our hormones,” Cynthia says in her book. “In turn, we are less likely to develop obesity, diabetes, vascular diseases, and autoimmune disorders.”At the end of this conversation, you’ll have the tools to decide if intermittent fasting is the right choice for the state of your own health.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Des 20231h 5min

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