The Methylene Blue Episode | Solo Biohacking Masterclass  : 1366

The Methylene Blue Episode | Solo Biohacking Masterclass : 1366

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption.


Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork.


You’ll Learn:

• Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood

• The exact signs that your dose is too strong, too weak, or in the Goldilocks zone

• How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience

• Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions

• How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters

• The link between mitochondrial health, fertility, libido, and long term anti aging strategies

• How to track sleep optimization, HRV, and performance signals to dial in your personal protocol

• The difference between aquarium grade dye and pharmaceutical grade formulations

• Why genetic testing for G6PD deficiency is essential before higher dose experimentation


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair


Thank you to our sponsors!

-BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.


Resources:

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

4:51 — History of methylene blue

7:38 — How methylene blue works

14:05 — Safety

17:53 — Dosing and timing guidelines

20:41 — Combining with red light therapy

22:41 — Quality and sourcing

23:17 — Dosing protocols

25:24 — Longevity and fertility effects

29:24 — Stacking options

32:10 — Common questions and FAQs

33:40 — Future research and wrap up

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1427)

Bulletproof Radio 2014 in Review! – #184

Bulletproof Radio 2014 in Review! – #184

Thanks for making 2014 a huge year for Bulletproof Radio! There are so many things to be grateful for – hitting #1 overall in the Health category on iTunes, surpassing 10 million downloads, and having incredible guests on the show to share life-changing biohacks and information. I appreciate you for tuning in and subscribing to our audio and video channels - making 2014 our most successful year ever!!! There are so many exciting things to look forward to in 2015, unbelievable guests, top of the line upgrades, and the best in Biohacking. This episode is a recap of the interviews from 2014, and features short clips of the best biohacks, bits of motivation, and pieces of life-upgrading information from every episode. Thanks for making 2014 a huge year for Bulletproof Radio, and enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Alan Cash: Upgraded Aging & Living Longer with Oxaloacetate – #183

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Dr. Dwight Jennings: A Live Look at Bite Realignment & How TMJ Impedes Performance #182

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Helen Irlen: Irlen Syndrome, & Visual Stimuli on Brain Performance – #181

Helen Irlen: Irlen Syndrome, & Visual Stimuli on Brain Performance – #181

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19 Des 201421min

James Swanwick: Read a Book a Day, Give Up Alcohol, & Be an Alpha Male - #180

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James Swanwick is an ESPN SportsCenter anchor, co-founder of Crocmedia, and the man behind the James Swanwick Show Podcast and The Alpha Male Club. James has been in print and TV journalism for over 20 years, and has been featured in the Associated Press, The Sun, Loaded Magazine, and many more newspapers and magazines. He authored the ebook Insider Journalism Secrets, and now teaches courses and provides coaching for aspiring journalists looking to break into the industry.   Why you should listen –     James comes on Bulletproof Radio to discuss how to read a book a day, why he gave up drinking alcohol 4 years ago, the difference between being good, excellent, and outstanding, and how to attract the kind of people that you want in your life. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Des 201459min

Dr. Dwight Jennings: TMJ, Jaw Pain, & Substance P - #179

Dr. Dwight Jennings: TMJ, Jaw Pain, & Substance P - #179

Dr. Dwight Jennings is a dentist and TMJ Specialist with expertise in treating orofacial pain, non-surgical orthodontics, and dental orthopedics. Dwight has been practicing neuromuscular dentistry for over 25 years, and has been involved in clinical research and creating new therapies for a large number of medical and developmental disorders that are associated with TMJ, jaw/bite misalignment, and high levels of systemic inflammation caused by the pain neurotransmitter, substance P.   Why you should listen –     Dr. Dwight comes on Bulletproof Radio to discuss how bite alignment impacts the rest of the body, why jaw pain is a systemic functional health disorder, the difference between orthodontics and dental orthopedics and how to find a specialist that can properly help you with TMJ, and how you can upgrade overall physical performance by adjusting your bite and jaw alignment. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Des 201455min

Jeffrey Smith: GMOs & Their Impact on Health - #178

Jeffrey Smith: GMOs & Their Impact on Health - #178

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9 Des 201454min

Dr. Grace Liu: Fixing the Gut Microbiome with Resistant Starch and Probiotics - #177

Dr. Grace Liu: Fixing the Gut Microbiome with Resistant Starch and Probiotics - #177

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