The Methylene Blue Episode | Solo Biohacking Masterclass  : 1366

The Methylene Blue Episode | Solo Biohacking Masterclass : 1366

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption.


Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork.


You’ll Learn:

• Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood

• The exact signs that your dose is too strong, too weak, or in the Goldilocks zone

• How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience

• Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions

• How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters

• The link between mitochondrial health, fertility, libido, and long term anti aging strategies

• How to track sleep optimization, HRV, and performance signals to dial in your personal protocol

• The difference between aquarium grade dye and pharmaceutical grade formulations

• Why genetic testing for G6PD deficiency is essential before higher dose experimentation


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair


Thank you to our sponsors!

-BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.


Resources:

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

4:51 — History of methylene blue

7:38 — How methylene blue works

14:05 — Safety

17:53 — Dosing and timing guidelines

20:41 — Combining with red light therapy

22:41 — Quality and sourcing

23:17 — Dosing protocols

25:24 — Longevity and fertility effects

29:24 — Stacking options

32:10 — Common questions and FAQs

33:40 — Future research and wrap up

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1427)

How to Control, Reframe and Change the Chatter in Your Head! – Ethan Kross, Ph.D. : 1072

How to Control, Reframe and Change the Chatter in Your Head! – Ethan Kross, Ph.D. : 1072

In this episode of The Human Upgrade you’ll find out how to harness the power of your inner voice to ease anxiety, improve physical and mental health, and deepen your relationship with others. “The mind is flexible, if we know how to bend it,” says psychologist and award-winning professor Ethan Kross, Ph.D., founder of the Emotion & Self Control Laboratory at the University of Michigan.He’s one of the world’s leading experts in controlling the conscious mind. He studies the ways in which your inner voice impacts your health, performance, decisions and relationships. He explores how people manage their emotions in order to better understand self-control. In particular, the conversations you have with yourself directly impact every part of your health and life.He explain that your inner voice functions to do things like this:Keep information active in your mindCoach you through problemsSimulate and plan aheadTell you storiesThat inner voice can be a powerful tool, giving you creativity, connection and definition. However, when the voice turns to negative and disorienting self-talk (chatter), it can create chaos and overwhelm by zooming into our problems, making you lose perspective.Ethan’s pioneering research mixes behavioral and brain research to get at the “why” behind human nature. He uses insights from his research to give people science-based tools they can use to change their behavior, be used in relationships, support a career move, improve physical performance, decrease stress, increase productivity and be used to reach life goals. You’ll use new tools like mental time travel, tough love and introspection.In this conversation about his book, “CHATTER: The Voice in Our Head, Why It Matters, and How to Harness It,” you’ll learn: How social media plays a part in our chatterHow to zoom out with a flexible mind, changing thoughts and distancing ourselvesHow to use tough loveHow to teach your kids about chatter from a young ageHow to help your friends with their own chatter (and what makes it worse)With Ethan’s experience studying the conscious mind for 20 years, you can learn how to turn negativity into an awesome tool that helps you master your own self-talk.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Jul 20231h 10min

Particle Size Matters: Masterclass in Using Silver for Biohacking - Steve Revelli : 1071

Particle Size Matters: Masterclass in Using Silver for Biohacking - Steve Revelli : 1071

Today, on The Human Upgrade, we talk to Steve Revelli about the long history and bright future of using silver nanoparticles as a biohacking silver bullet. Steve's background is in science and education, now serving as the QA Manager at American Biotech Labs, LLC, the brand which produces Silver Biotics—a long-time resident of my own medicine cabinet. The conversation covers the difference between pathogenic bacteria and probiotics, how silver under a concentration of 40 parts per million can target harmful bacteria while leaving healthy probiotics intact, the importance of nanoparticle size, antibiotic resistance, animal and agricultural applications, and so much more. You will learn how they use silver in the world of medicine (because they actually do and have for more than a hundred years) and how/when to use it yourself, whether topically, supplementally, or otherwise. This, my free-thinking friends, is a masterclass in using silver for biohacking.00:03:06 — Retelling the Long Story of Silver• Historical meaning of “born with a silver spoon”• Microbial elements of AG404–why it works• Chemistry deep dive, searching for missing electrons• Why doesn’t silver attack healthy cells?• Differences between prokaryotic cells• More is not always better00:11:22 — Delivery Systems to Improve Your Health• Importance of nanoparticle sizes in effective use• One warning: avoiding high salt• Using AG404 in nasal spray during air travel• Other off-label uses for Silver Biotics • Silver particles for immune support • Topical use for fighting infection • 70-year medical history of using silver for burns • Using a vertical sprayer for delivery• Code: DAVE for 30% off at silverbiotics.com00:27:09 — Cosmetic Benefits & Antibiotic Resistance• New formulations from Silver Biotics• Wrinkles, acne, cuts, scrapes, etc.• Facial serum vs. skin cream• Fighting antibiotic resistant bacteria • Pet care and successful applications in agriculture • Safety an ingestion cycles • Turning blue from silver toxicity • Relieving bacterial burden from your sinuses • Code: DAVE for 30% off at silverbiotics.comResources• Shop: Use code DAVE for 30% off at silverbiotics.com• Instagram: @silverbioticsThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Jul 202343min

Let Them Eat Dirt: Biohacking Family Nutrition - Andrea Bemis : 1070

Let Them Eat Dirt: Biohacking Family Nutrition - Andrea Bemis : 1070

Today, we're delving deep into the importance of dirt, not just as soil beneath our feet, but as a key factor in regenerative agriculture and biohacking. Our guest, Andrea Bemis, is an expert in sustainable organic farming and a passionate advocate for nurturing healthy babies and children. Together, we explore the power of the family dinner and the significance of avoiding harmful chemicals and additives in the food we provide for our kids.Andrea Bemis, the brilliant mind behind the farm-to-table blog "Let Them Eat Dirt," joins us as our special guest. She has authored remarkable books, "Dishing Up the Dirt" and "Local Dirt," which provide invaluable insights into creating a healthy and nourishing food environment for children. Through our shared belief in empowering kids to make healthier choices, we aim to guide parents away from the junk and chemicals that can harm their children's well-being and towards more sustainable, locally sourced and economical options.Join us as we share our tips and tales from our own dinner tables, and our top strategies for nourishing your children with whole foods that taste good, too. Welcome, Andrea, to The Human Upgrade. 00:02:07 — Avoiding Processed Foods: Dangers of Heavy Metals & Artificial Sweeteners• How processed foods can change brain chemistry• The mistake parents of young children make when it comes to food• Tips for getting kids to eat diverse foods and flavors• Logistics of living on a farm• Benefits of buying from a CSA• The Baby Food Facts Report findings on sweeteners in baby food• Heavy metals in baby food00:21:01 — Healthy, Fast & Economical Recipes for Kids• Most economical ways to make healthier baby food at home • Recommended cooking oils for kids and why• Being mindful of how much kids are snacking• Not forcing your kid to eat when they’re not hungry• Andrea’s fast recipe ideas• How salt impacts babies’ digestive system• Read: Nourishing Traditions by Sally Fallon00:43:45 — Andrea’s Favorite Sweetener & Farm Life Insights• Andrea’s favorite sweetener for kids• Pros and cons of kale• Finding quality bacon • The most difficult crops to grow• Teaching your kids where food really comes from• Why small farms are so incredibly important & economicalResources• Website: dishingupthedirt.com• Instagram: @andreabemis• CSA: gotumbleweed.com• Read: letthemeatdirtkids.comThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Jul 202355min

What Happens in the Gut, Starts in the Mouth – Naveen Jain : 1069

What Happens in the Gut, Starts in the Mouth – Naveen Jain : 1069

Today, a dear friend of the show and someone who's disrupted a huge part of the healthcare industry joins us for an informative chat on the critically important oral microbiome—and from a wider perspective—how and why the human body gets sick. Naveen Jain, founder of Viome—a data company that’s changing the world of health and wellness—goes deep on the latest in anti-aging, what's going on in your mouth and how that affects everything else in your body, the perils of mouthwash, the future of AI-powered analytics, business building with the right priorities in mind, and a whole lot more.And it all comes right back to the base definition, the core understanding, of what biohacking is—using the information and technology around us to live a longer and healthier life. Naveen’s company, Viome, is doing just that. You won’t want to miss this exclusive look into the future—for your own long-term health, or for that of society as a whole.00:01:44 — What Is It About the Human Body That Causes Us To Be Sick?• Fundamentally changing the way we look at the body • Dave’s homemade mouthwash and why he stopped using it • Power of individuality when it comes to health and longevity • Different impacts of foods on identical twins (Research)• What happens in the gut, starts in the mouth • The signals chewing your food sends to your body• Why a healthy oral microbiome means healthy sex 00:09:33 — Viome: Supercharging Human Data Analytics • Reading out the transcript from your body• Determining a diet-based source of bad breath • Viome’s biomarkers and aging score• Looking at RNA va. DNA• Shop viome.com and use code DAVE10 to save 10%• Pooling the data from 550,000 samples analyzed• Custom-made diet recommendations for your genetics• Affordability of Viome testing kits • Predicting mouth and throat cancer at a 95% rate • Personalized oral microbiome toothpaste gel 00:24:13 — Longevity & Lifespan: Our Health Is Our Wealth• Increasing our healthspan—adding truly viable years• Dave calls out the lifespan cowards• Choosing how and when we die: the ultimate goal for society • Naveen shares 5 ways to live a long and healthy life • Nutrition, getting the right fuel for the car• Stress management, escaping fight-or-flight mode• 40 Years of Zen neurofeedback therapy• Why you should quit your shitty stressful job• Smarter Not Harder by Dave Asprey• Prioritizing exercise, 30 minutes a day • Getting proper sleep, quality vs. quantity • Sleep with Dave: 14-day sleep challenge00:37:35 — A Message for the World’s Wantrepreneurs• Find a purpose and live 10 to 15 years longer• Focus on helping people live better—not making more money• Parasitic nature of modern commerce• Amazon’s quality spiral and the race to the bottom • Impacting the world in your uniquely powerful way• Our success will never be defined by how much money we madeResourcesInstagram: @viomeInstagram: @naveenjainceoViome: viome.com (Code DAVE10 to save 10%)Website: naveenjain.comThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Jul 202345min

You Control Your Own Karma! – Sadhguru : 1068

You Control Your Own Karma! – Sadhguru : 1068

IN THIS EPISODE OF THE HUMAN UPGRADE™️... Sadhguru, a yogi, mystic, visionary and spiritual master who spreads wisdom around the world, clarifies the meaning of karma (no, it’s not a checklist of good and bad deeds) and explains how much you’re in charge of your own karma. His most recent book, “Karma: A Yogi’s Guide to Crafting Your Destiny,” breaks down the ways in which karma frames our lives.“It’s time to unpack the most overused, abused and yet indispensable world in the spiritual vocabulary of the world,” says Sadhguru in his book. “It is time to examine how karma is connected to some of the most vital areas of human inquiry: the meaning of life and above all, how to live it.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Jul 202342min

Happiness Starts with Your Brain Type! – Dr. Daniel Amen : 1067

Happiness Starts with Your Brain Type! – Dr. Daniel Amen : 1067

IN THIS EPISODE OF THE HUMAN UPGRADE™...“Americans are the unhappiest they have been since the Great Depression,” says Dr. Daniel Amen. But he’s determined to change that. He’s a physician and double board-certified psychiatrist who looks at happiness as a brain function. After studying more than 200,000 brain scans of people from 155 countries, Dr. Daniel Amen discovered five primary brain types and seven neuroscience secrets that influence happiness.“I wanted to spend my time and energy and research on happiness because, ultimately... happiness is a moral obligation because of how you impact other people,” Dr. Amen says. “The big central point [is] the brain is the organ of happiness, and if your brain is not healthy, you are not likely to be happy.”What makes you happy? The answer lies in knowing your specific brain type and how it’s being influenced by seven specific chemicals.Happiness originates in distinct brain regions: pleasure in the orbitofrontal cortex; motivation and habit formation in the basal ganglia; and mood and cognitive flexibility in the brain stem.You may be one or a combination of these five primary brain types: (take this brain assessment to find out yours)Balanced: you have a very healthy brainSpontaneous: you have low dopaminePersistent: you’re often worried, rigid, and inflexibleSensitive: you need other people and isolation is hardCautious: your GABA levels are lowLearn more about brain types and what actually boosts your happiness according to neuroscience in Dr. Amen’s book, "You, Happier: The 7 Neuroscience Secrets of Feeling Good Based on Your Brain Type.”“Happiness comes from moving your life forward toward your life goals with meaning and purpose, based on your values, despite whatever obstacles are in your way,” Dr. Amen says. “A happy life doesn’t focus on the past with regret or look to the future with fear.” See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Jul 20231h 21min

You’re Not Crazy, Toxic Mold Exposure Is Poisoning Your Brain - Brian Karr : 1066

You’re Not Crazy, Toxic Mold Exposure Is Poisoning Your Brain - Brian Karr : 1066

If you have all sorts of unexplained health problems in your home, where you work, or where you go to school, symptoms can be very different. One person's gaining fat, another person's always tired, other people have dark circles, emotional irregularity, sudden weight gain, onset of allergies that no one can explain, on and on.In the episode today, you learn the smarter, not harder, ways to deal with toxic mold exposure in your environment from one of the world’s leading experts on the matter. Our guest is Brian Karr. He's a second-generation indoor environmental consultant and he works with hypersensitive individuals with complex medical conditions. He's the co-founder of We Inspect, an environmental testing company which works to help people understand mold, mycotoxins, and even bacterial toxins that exist in your homes. He takes time to explain what's (usually) there, why it’s important—even down to the genetic level—and what it's doing to you.Go back to the definition of biohacking… The art and science of changing the environment around you and inside of you so that you have full control of your own biology. If your environment is moldy and has biotoxins, maybe you don't have control of your biology—the mold does.Brian's become a go-to guy for medical doctors across the country, helping more than 5,000 people as sensitive as I used to be to create healthier living environments. You're going to learn a lot in this episode, even if you're saying… Well, I don't have a mold problem. You'd be very surprised.00:17:00 — Meeting the Mold (and Brian) Head On• Dave’s younger years battling his own health • The xenoestrogen that took over his life• Brian Karr’s background and introduction• We Inspect environmental testing company • Moldy Movie: moldymovie.com• How Brian married into the business and fell in love • Building an infrastructure to serve the country• Betsy Maldonado’s story 00:15:02 — We Inspect: Spotlighting Innovation & Access • We Inspect’s process—what’s unique and special?• Most mold is hidden out of plain sight • Perils of dry mold: more mobile than wet, living mold• The importance of knowing what to look for• Prioritizing innovation and accessibility • Training program: Mold Finders Method • Mobile app: We Inspect Together• Pitfalls of other, commercially driven services 00:29:18 — Dealing With Mold in Our Day to Day Lives• Brian’s game plan for getting out of a moldy lease • Does spraying bleach work?• Why Dave avoids AirBnbs• Homebiotic: homebiotic.com• Balancing removal options • Three easy steps to take in your home• Understanding the Human Cloud Effect • Gaps in capability of air testing • Effectiveness of dust sampling • Find Out If Your Home Is Making You Sick• 100M structures in the US have meaningful mold problems00:50:04 — Looking Ahead At Life With Less Mold• 90% of structures are exposed to toxic mold• Danger Coffee: dangercoffee.com• What is truly pure?• Balance of bacteria vs. mold in caves • Added susceptibility of women and children• 40% of population impacted by mold exposure • Story time: Dave’s mold-triggered PANDASWE LOVE OUR SPONSORS! CHECK THEM OUT:• We Inspect environmental testing company • The Dust Test: thedusttest.com/dave• YesWeInspect.com/Dave• Moldfinders on Instagram• Brian Karr on LinkedIn• Moldfinders on Facebook• Moldy MovieThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Jun 20231h 9min

Live From The 9th Annual Biohacking Conference: Biohacking the Red Planet with Vera Mulyani : 1065

Live From The 9th Annual Biohacking Conference: Biohacking the Red Planet with Vera Mulyani : 1065

In this special episode of The Human Upgrade LIVE from the 9th annual Biohacking Conference in Orlando Florida, Dave speaks Vera Mulyani, co-founder of Astrobiome and Mars City Design. Vera discusses the connection between biohacking and living on Mars and emphasizes the importance of designing the Martian environment to control human biology, taking into account mental health and architectural expertise. They also highlight challenges like toxic chemicals in spacecrafts and the need to biohack humans for space. Vera introduces Astrobiome, a microbiome product made from fermented bacteria, designed to optimize gut health in extreme conditions. Success stories demonstrate its effectiveness in improving health and performance. The podcast explores the intersection of biohacking, space exploration, and the significance of microbiome health in Mars-like environments.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Jun 202323min

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