10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


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• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1428)

Jen Wittman: Thyroid, PTSD, & Medicinal Cannabis  - #201

Jen Wittman: Thyroid, PTSD, & Medicinal Cannabis - #201

Jen Wittman is a Certified Holistic Health Expert & Coach specializing in practical solutions for those suffering from thyroid and autoimmune conditions. She provides one-of-a-kind, long-lasting health overhauls at her sites, Thyroid Loving Care, The Healthy Plate, and Your Best Thyroid Life. She is author of the book: Healing Hashimoto's Naturally and the popular guides: The Super-Mom's Guide to Managing Thyroid Disease and The Partner's Guide to Thyroid & Autoimmune.   Why you should listen –     Jen comes on Bulletproof Radio to discuss the relationship between PTSD and food, how to manage Hashimoto’s Thyroiditis, the misdiagnosis of autoimmune diseases, and the therapeutic use of CBD oil and cannabis. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Mar 201551min

Rick Doblin: Psychedelic Healing with Marijuana, MDMA, Psilocybin, & Ayahuasca  - #200

Rick Doblin: Psychedelic Healing with Marijuana, MDMA, Psilocybin, & Ayahuasca - #200

Rick Doblin is the Founder and Executive Director of the Multidisciplinary Association for Psychedelic Studies (MAPS), a non-profit research and educational group that he started in 1986 to develop medical, legal, and cultural contexts for people to benefit from the careful use of psychedelics and marijuana. Rick has a Ph.D. in Public Policy from the Harvard Kennedy School of Government, and also studied under Dr. Stanislav Grof, becoming one of the first practitioners to be certified in Holotropic Breathing. Rick works to progress the research and education behind the benefits of psychedelics and marijuana primarily as prescription medicines, but also for personal growth for otherwise healthy people. Why you should listen – Rick comes on Bulletproof Radio for an extended episode to discuss the safe use of psychedelics as medicine, floatation tanks and Holotropic Breathing as psychedelic alternatives, the dark side of recreational psychedelic substances, and the therapeutic use of substances such as psilocybin, MDMA, ayahuasca, and cannabis. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Mar 20151h 44min

Dr. Tim Jackson: Heavy Metal Toxicity, MTHFR, & Genetic Testing - #199

Dr. Tim Jackson: Heavy Metal Toxicity, MTHFR, & Genetic Testing - #199

Dr. Tim Jackson is a Functional Endocrinologist, a Doctor of Physical Therapy (DPT), and an expert in nutritional biochemistry and digestive health. He is the featured doctor for the MTHFR Support group of healthcare professionals, and the founder of HealYourBody.org, and works to educate the healthcare community and public about the role of methylation in both health and disease. He is also trained in Active Release Technique, and is working on his certification as a Certified Nutrition Specialist (CNS).   Why you should listen –     Dr. Tim comes on Bulletproof Radio to discuss heavy metal detoxification, the MTHFR gene, methylation and genetic testing, and why it is so important to prevent disease instead of needing to fix it. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Feb 201556min

James Baber: Toxic Mold: The Hidden Dangers - #198

James Baber: Toxic Mold: The Hidden Dangers - #198

James Baber is a Senior Product Management professional with more than eighteen years of experience in technology product management, development, and operations. James is on Bulletproof Radio not because of his experience and knowledge in technology and business, but because he is a survivor of toxic mold exposure and has a wealth of information to share about this little-known problem that could be affecting over 100 million people in the US. James will be featured in the upcoming documentary, Moldy, which chronicles the dangers of environmental toxic mold, and sheds light on just how big of a problem it is, and how to go about dealing with it.   Why you should listen –     James comes on Bulletproof Radio to discuss his story of toxic mold exposure, the long list of symptoms you experience when exposed to mold, the reasons why doctors don’t consider mold exposure to be a serious problem, and the important lab tests and data that help with diagnosing mold exposure. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Feb 201557min

Abel James: Fat, Food Labeling, & His Wild Diet - #197

Abel James: Fat, Food Labeling, & His Wild Diet - #197

My friend Abel James, the Fat Burning Man, has been off the grid working on his new book, The Wild Diet. Abel has been on Bulletproof Radio before, and we have done a number of video series and interviews together. It's always great to get him back on the show!   Why you should listen –     Abel comes on Bulletproof Radio to discuss why food is more than just fuel, the ideal body fat percentage, why it’s so important to reconnect with nature, and some dirty little secrets about food labeling – is the food industry really putting beaver butts in our food?! Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Feb 201556min

Stew Friedman: Success, Leadership, & Less Work - #196

Stew Friedman: Success, Leadership, & Less Work - #196

Stew Friedman is a Practice Professor of Management at UPenn’s Wharton Business School, and the Founding Director of the Wharton Work/Life Integration Project. Stew is also the author of the award-winning best-seller, Total Leadership, which utilizes the exercises taught in his classroom at Wharton to increase leadership capacity and performance in all areas of life, not just business. His newest book, Leading the Life You Want, builds on the skills taught in Total Leadership to help people develop a better work-life balance and find more meaning and satisfaction with their jobs and relationships. In addition, Stew is a regular contributor to publications such as the Harvard Business Review, and has served in an advisory role for a wide range of companies and organizations, including the US Department of Labor, the United Nations, and even two White House administrations.   Why you should listen –     Stew comes on Bulletproof Radio to discuss how to find your mission and purpose in life, the science of leadership, mastermind groups, and why you can get more done by focusing less on work. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Feb 201554min

Jeff Hays: Entrepreneurship, Crowdfunding, & Controversy - #195

Jeff Hays: Entrepreneurship, Crowdfunding, & Controversy - #195

Bought, the Movie will be available to view for free from Feb 20th – Mar 6th. Click HERE to register and watch one of the most important documentaries you will ever see!   Jeff Hays is a filmmaker, serial entrepreneur, and the visionary behind Capstone Entertainment, a film and television production and distribution company. Jeff is most well known for his work on the controversial documentary, FahrenHype 9/11, and for his production of On Native Soil, for which he was nominated for an Academy Award in 2005. His most recent work was the production of Doctored, a deep investigation exposing the unseen tactics, deception, and criminality that are rampant in the medical industry, a film that became one of the most successful independently distributed DVDs of 2012 following its release in theaters. Jeff is currently working on a follow-up film titled Bought, which will dive into the world of Big Pharma and the controversies behind vaccines and the truth about GMOs in the American food supply. On top of his film-making prowess, Jeff has also started more than 20 companies, including NextFitness, Zingback, and Talk 2 Technologies, and he also owns eight tech patents for good measure.   Why you should listen –     Jeff comes on Bulletproof Radio to discuss crowdfunding, how to avoid the buzz-saw of failure, the controversy surrounding vaccines and GMOs, and walking the line between two extremes to find the truth. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Feb 201551min

Dr. Robyn Benson: Healing with Oxygen, Hydration, & Biohacking - #194

Dr. Robyn Benson: Healing with Oxygen, Hydration, & Biohacking - #194

Dr. Robyn Benson is a Doctor of Oriental Medicine, and Founder of the Santa Fe Soul Center for Optimal Health, and The Self-Care Revolution. She has traveled to more than 70 countries and treated 80,000+ patients using revolutionary new technologies and techniques to prevent and reverse disease, including acupuncture, IV therapies, chiropractic, therapeutic massage, and a number of oxidative therapies such as Prolozone. Her holistic practice focuses on helping people to reclaim their wellbeing by utilizing cutting-edge technologies combined with better daily choices in the areas of diet, exercise, and stress management to create profound improvements and empower them to take control of their own health.   Why you should listen –     Dr. Robyn comes on Bulletproof Radio to discuss cutting edge oxidative therapies, the importance of hydration, how to use your own body to heal itself, and some of her biohacking secrets. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Feb 201550min

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