10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



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• Dave Asprey’s BEYOND Conference: https://beyondconference.com

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• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1427)

Dr. Robert Rowen: Treating Ebola & Ozone Therapy - #168

Dr. Robert Rowen: Treating Ebola & Ozone Therapy - #168

Dr. Robert Rowen is known as “The Father of Medical Freedom” for pioneering the nation’s first law protecting alternative medicine, and has used ozone therapy to treat a host of different ailments since 1986. Dr. Robert was trained at Johns Hopkins University and UCSF Medical School, has been board certified and recertified by the American Boards of Family Practice and Emergency Medicine, and also served on the Alaska State Medical Board and as president of the International Oxidative Medicine Association. He is currently the Oxidation Workshop Chairman for the American College of the Advancement of Medicine, and as one of the foremost experts in the use of nature’s natural cleanser, ozone, he has been running training courses for medical practitioners in all forms of ozone therapy as an oxidation teacher since 1994.   Why you should listen –     Dr. Rowen comes on Bulletproof Radio while in quarantine to discuss his experience presenting Ozone therapy to medical practitioners in West Africa, the benefits and types of ozone therapies, the power of oxygenation therapy as a treatment for curing and preventing ebola, and how you can find treatments or even set up ozone therapy in the comfort of your own home. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Nov 201447min

Bo Eason: Being the Runt of the Litter & The Power of Your Personal Story - #167

Bo Eason: Being the Runt of the Litter & The Power of Your Personal Story - #167

Bo Eason is a former NFL player, acclaimed Broadway playwright and performer, and an international presence/story coach. He has trained with some of the world’s most brilliant performance and movement coaches, and has logged over 20,000 hours on stage crafting and presenting his personal story. His play, Runt of the Litter, has toured in over 50 cities, and opened in New York to critical acclaim. Bo is now dedicated to helping other tap the power of their personal story in order to become effective, persuasive communicators.   Why you should listen –     Bo comes on Bulletproof Radio to discuss the power of goals, why a dedication and commitment to perfection is essential for success, how to deal with criticism, and the power of sharing your personal story. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Okt 20141h 2min

Dan Pena: Real Success, Performance, & Being High on Life - #166

Dan Pena: Real Success, Performance, & Being High on Life - #166

Dan Pena is the founder of Quantum Leap Advantage (QLA), a mentoring program that teaches people how to achieve unprecedented levels of success and high performance. Dan is also currently Chairman and Founder of The Guthrie Group, an international investment consortium group, and over his lifetime has helped to found and grow several multimillion-dollar companies. He draws on his experience and success in business to coach thousands of people every year as an eccentric mentor, lecturer, and motivational speaker, teaching them the proven methods and characteristics that make the highest performing individuals successful and allow them to achieve their dreams.   Why you should listen –     This is a special in-person interview shot live from the 2014 Bulletproof Conference! Dan comes on Bulletproof Radio to discuss the characteristics of high performance individuals, how to tear people down in order to build them back up as a better version, what it takes to have true commitment and accountability, and what you can accomplish when you’re high on life. You don’t want to miss his top    “3 “ recs for kicking ass at life! Enjoy the show.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Okt 201438min

Dr. Bronner’s Magic: Sustainability, Psychedelics, & GMOs – #165

Dr. Bronner’s Magic: Sustainability, Psychedelics, & GMOs – #165

David Bronner is the grandson of Dr. Emanuel Bronner, the founder of Dr. Bronner’s Magic Soaps, one of the world’s largest personal care product companies to be certified under the USDA National Organic Program. David has a B.A. in Biology from Harvard, and has been president of Dr. Bronner’s Magic Soaps since 1998. He is a board member of both the HIA and Vote Hemp, a contributor to the Huffington Post, and is working to bring hemp farming back to the US, as well as raise awareness of GMO, sustainability, and fair trade best practices.   Why you should listen –     David comes on Bulletproof Radio to discuss the problem with GMOs, the dangers of using chemicals and genetic engineering on our food, how Bronner’s Magic Soaps keeps its supply chain and products so pure, and why he is so passionate about the movements for hemp, sustainability, and psychedelics. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Okt 201444min

Doug McGuff: Myokines, & the Endocrine Nature of Muscles - #164

Doug McGuff: Myokines, & the Endocrine Nature of Muscles - #164

Dr. Doug McGuff is an Emergency Medicine Physician, exercise science researcher, and weight lifter. In addition to his work at Blue Ridge Emergency Physicians, P.A., Doug also owns and operates his own gym, Ultimate Exercise, and co-authored the best-selling book Body by Science, along with John Little.   Why you should listen –     Doug comes on Bulletproof Radio to discuss myokines and their role in muscular training, the role of the gut microbiome in fighting inflammation, how to control your nerves with stress inoculation, and the science behind oxygen saturation, breathing, & exercise. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Okt 20141h 10min

Philip McKernan: Finding Meaning, Managing Relationships, & Understanding Value - #163

Philip McKernan: Finding Meaning, Managing Relationships, & Understanding Value - #163

Philip McKernan is a philosopher, international best-selling author, and some say an “enlightened hooligan”. Philip has traveled the world speaking about the importance of overcoming personal obstacles, gaining clarity, and cultivating the confidence to believe in yourself, and has shared the stage with esteemed speakers such as Steven Covey, Richard Branson, and the Dalai Lama. He has worked with people from Olympic athletes, TV personalities, entrepreneurs, housewives to billionaires who have gone bankrupt, and everything in between.   Why you should listen –     Philip comes on Bulletproof Radio to discuss how to find more meaning, how to accelerate growth to achieve the next level, whether or not money buys happiness, and how to know what you actually want vs what you think you want. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Okt 201455min

Biohacking Live with Superman, Brandon Routh: Hacking Hollywood & Avoiding Kryptonite - #162

Biohacking Live with Superman, Brandon Routh: Hacking Hollywood & Avoiding Kryptonite - #162

Brandon Routh is an actor and former fashion model, and has appeared in numerous TV shows and movies, however you may know him best from his role portraying The Man of Steel in the 2006 blockbuster film, Superman Returns.   Why you should listen –     Brandon comes on Bulletproof Radio to discuss the impact of the Bulletproof Diet on his family, how he hacks the Hollywood lifestyle, how the Bulletproof Diet has helped to upgrade his acting and performance, and to do a ton of biohacking in person with Dave. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Okt 20141h 6min

Zach Even-Esh: Stress, Recovery, & the Art of Coaching #161

Zach Even-Esh: Stress, Recovery, & the Art of Coaching #161

Zach Even-Esh is the Founder of the Underground Strength Gym, and creator of the Underground Strength Coaching Certification Program. Zach won Teenage Mr. Israel in 1994 in the first of three bodybuilding competitions, and has since trained hundreds of athletes ranging from youth to Olympic level, and also serves as a consultant for several of the top Division 1 wrestling teams in the US. Zach’s online training courses have helped tens of thousands of people around the world develop greater strength in mind, body, and in life.   Why you should listen –     Zach comes on Bulletproof Radio to discuss stress inoculation, the art of coaching, the importance of adequate recovery, and how to know which information you should trust. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Okt 20141h 4min

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