Moderna and Flagship Pioneering: Noubar Afeyan

While she was a student at business school, Shazi Visram ran into an old friend—a new mother of twins. The friend confided she felt like a bad mom because she had no time to make her kids healthy meals. That gave Shazi her initial idea: why not make organic pureed baby food, and sell it frozen instead of jarred? People told her she was crazy to take on Gerber, but she convinced dozens of friends and family to invest in Happy Baby. Nearly 20 years later, the brand is known as Happy Family Organics and reportedly makes more than $200 million a year.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Juli 20221h 8min

According to the 2022 report from the Intergovernmental Panel on Climate Change (IPCC), the world needs to cut carbon emissions drastically to avoid the worst effects of global warming. But that’s not all. In addition to reducing emissions, we also need to remove 6 to 10 billion tons of carbon dioxide from the atmosphere each year by 2050. This week on How I Built This Lab, Guy talks with Jan Wurzbacher, co-founder and CEO of Climeworks. They discuss how Jan and his team built the world’s largest direct air capture facility, which filters carbon dioxide from the air and stores it permanently underground. Plus, Jan’s optimistic vision of how humans can achieve the goal of reversing climate change. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Juni 202237min

Jimmy Fallon may talk like a comedian, but he thinks like a restless entrepreneur. In addition to his day job as host of The Tonight Show, he runs a TV production company, writes best-selling children’s books, and creates products you never knew you needed, like all-day pajamas and “hands high” jerseys that show the name of your favorite team in the armpit. As a kid, Jimmy was obsessed with perfecting his impressions of Richard Pryor and Steve Martin, with the goal of one day starring on Saturday Night Live. After an incredibly successful 6-year run on that show, he tried to make it in film, only to eventually find his way to one of the most coveted jobs in television. Today, he’s constantly generating new ideas, whether for a new TV show, or a Christmas tchotchke called Elvis on the Shelvis.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Juni 20221h 11min

YouTubers Kelsey MacDermaid and Becky Wright – better known as The Sorry Girls – have always had an affinity for production. When they met as film students back in 2010, little did they know that the DIY videos they were creating for fun would eventually lead to full-fledged careers co-founding and leading their own media company. But building to where they are now, with over 2 million subscribers and counting, didn’t exactly come with a blueprint…This week on How I Built This Lab, Kelsey and Becky talk to Guy about pursuing the uncharted territory of a YouTube career, their philosophies on navigating brand deals, and their take on growing a business in the creator economy without compromising on values. Check out The Sorry Girls on YouTube and try your own hand at DIY: https://www.youtube.com/c/TheSorryGirls/featured See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Juni 202243min

After PayPal sold to eBay in 2002, Max Levchin could have relaxed on a beach for the rest of his life. But that’s not the kind of person he is. He isn’t happy unless he’s coming up with new ideas and building companies – so much so that he actually fell into a dark place after leaving PayPal. He didn’t fully find himself until years later, when he rediscovered his passion for the “hard, valuable, fun” problems of fintech. Now, Max runs another billion-dollar company: Affirm, a “buy now, pay later” service that’s transforming how we purchase things on credit. This is the second part of a two-part conversation with Max; to hear the story of PayPal, be sure to listen to part 1! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Juni 202257min

Serial entrepreneur Mark Cuban was one of the very first guests on How I Built This, way back in 2016. Mark has been founding and investing in startups for decades, but he’s never put his name on a company until now. This week on How I Built This Lab, Mark joins Guy to talk about what he’s been up to since he was last on the show. They discuss his interest in NFTs and how his latest business, the Mark Cuban Cost Plus Drug Company, is looking to disrupt the pharmaceutical industry. Listen to Mark’s original How I Built This episode: https://wondery.com/shows/how-i-built-this/episode/10386-serial-entrepreneur-mark-cuban/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Juni 202234min

During its formative years in the late 1990's, Paypal attracted an extraordinary group of young entrepreneurs, who then went on to build some of the best known companies in tech. They became known as The PayPal Mafia—and Max Levchin was one of the leaders. A computer genius from Soviet Ukraine, Max joined Peter Thiel, Elon Musk, Reid Hoffman and others as they grew PayPal into a massively successful online payment service. Along the way, they encountered almost every start-up challenge imaginable, including the emotional ouster of Elon Musk as CEO. After PayPal was acquired by eBay in 2002, Max couldn't sit still, so he launched a startup lab that eventually led to another successful fintech company: Affirm. Guy will talk to Max about Affirm next week, in the second episode of this two-part series. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Juni 20221h 28min

Drive. Docs. Chrome. Maps. Gmail. Android. What do these products have in common? Of course, they’re all Google, but what you may not know is that they all came to fruition under the management of the same person: Sundar Pichai. This track record in product development ultimately landed Sundar the CEO role at one of the biggest, most innovative companies in the world. This week on How I Built This Lab, Sundar reflects on the unique journey that led him to Google, and the values that inspire and drive his leadership today. He and Guy also discuss Google’s recent advances in artificial intelligence, and how the company is reimagining the workplace as offices across the globe reopen.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Juni 202234min