Moderna and Flagship Pioneering: Noubar Afeyan

In 2007, three friends set out to address a common frustration: the long waits and scheduling hassles of booking a doctor's appointment. But soon after launching their online scheduling platform Zocdoc, Oliver Kharraz, Cyrus Massoumi and Nick Ganju ran into a classic chicken-and-egg problem: they had to show potential patients that doctors were available for bookings, while frantically convincing reluctant doctors to sign up. The company solved this challenge and started to grow, but then faced an even bigger hurdle: an identity crisis over its business model, which caused a major rift between its partners. Now Zocdoc is going through another transformation: offering video appointments in the age of COVID-19. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Aug 20201h 5min

Samantha Bee, the host of Full Frontal with Samantha Bee, has been filming her show from her backyard in upstate New York since March. While Samantha remains unsure about returning to the studio, she's optimistic that her team will continue producing a broadcast-quality show remotely. These conversations are excerpts from our How I Built Resilience series, where Guy talks online with founders and entrepreneurs about how they're navigating turbulent times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Aug 202019min

In the early stages of the lockdown, Airbnb was in a freefall: it lost 80 percent of its business and laid off a quarter of its staff. But CEO Brian Chesky tells Guy that as people start to travel again—in cars, and closer to home—the company is beginning to recover. These conversations are excerpts from our How I Built Resilience series, where Guy talks online with founders and entrepreneurs about how they're navigating turbulent times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Aug 202023min

In 2010, a tragic personal event changed the trajectory of Nancy Twine's life. Suddenly, her promising job on the trading floor at Goldman Sachs no longer seemed fulfilling; she wanted something more. Drawing inspiration from the homemade hair treatments she used to make with her mom, Nancy decided to create a line of shampoos and conditioners that catered to all textures of hair without using harmful additives. But as an African American entrepreneur pitching beauty products to white, male investors, she had a tough time raising money. Finally in 2013, with an investment of $100K, Nancy launched Briogeo, eventually landed it in Sephora, and—even in the midst of an economic crisis—is expecting it to do $40M in sales this year. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Aug 20201h 10min

Guy speaks with Jessie Woolley-Wilson, CEO of DreamBox, an online math learning program for K-8 students. The platform has added two million new users during the lockdown, but that rapid growth has created "stretch marks" and new challenges for leadership. These conversations are excerpts from our How I Built Resilience series, where Guy talks online with founders and entrepreneurs about how they're navigating turbulent times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Aug 202020min

Within weeks after the pandemic lockdown, the fitness program Zumba rapidly shifted gears and launched its own online workout platform. Co-founder Alberto Perlman says it's helping keep the community connected, fit, and—for instructors—employed. These conversations are excerpts from our How I Built Resilience series, where Guy talks online with founders and entrepreneurs about how they're navigating turbulent times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Aug 202020min

So—no joke: two guys really do walk into a bar. While sharing a few drinks on a winter night in New York City, best friends Michael Kirban and Ira Liran met two young women from Brazil. That chance encounter eventually led to a business idea: to sell Brazilian coconut water in the US, as an alternative to Gatorade. In 2004, Michael and Ira launched Vita Coco, only to discover that another startup—Zico—was selling a nearly identical product. The two companies went to war, using the time-honored tools of corporate sabotage, but eventually Vita Coco emerged as the top selling coconut-water in the U.S. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Aug 20201h 10min

Hello Sunshine—a production company founded by Reese Witherspoon—has created TV shows Little Fires Everywhere, The Morning Show, and Big Little Lies. Fresh off 18 Emmy nominations, Hello Sunshine's CEO Sarah Harden and Head of Television & Film Lauren Neustadter are hopeful they will find a way to begin filming again safely, despite COVID-19's impact on Hollywood this year. These conversations are excerpts from our How I Built Resilience series, where Guy talks online with founders and entrepreneurs about how they're navigating turbulent times. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Aug 202016min