10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1429)

Bill Harris: Hacking Meditation with Holosync - #186

Bill Harris: Hacking Meditation with Holosync - #186

Bill Harris is the Founder, President, and Director of the Centerpointe Research Institute and creator of the Holosync Solution program, which utilizes sound technology to alter brain-wave patterns to enhance meditation and create mental, emotional, spiritual, and health benefits. Bill is a Certified Trainer of Neuro Linguistic Programming, is trained in Ericksonian Hypnosis, and has degrees from Berklee College of Music, Portland State University, and the University of Portland. He specializes in using contemporary psychology, Eastern philosophy, chaos theory, and neurotechnology to affect human evolution, change, and healing. Bill has shared the stage with many of the world’s top human potential leaders, including the Dalai Lama, Dr. Stephen Covey, Jack Canfield, and Sir Richard Branson, and nearly 2 million people in over 190 countries have used Centerpointe programs to improve their lives. Why you should listen – Bill comes on Bulletproof Radio to discuss sound-influence on the brain, the benefits of meditation and Holosync Sound Technology, how to control awareness and your reactions to trauma, and maximizing your performance impact. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Jan 20151h 8min

Robert Lee: Breathing for Performance, Focus, & Freediving – #185

Robert Lee: Breathing for Performance, Focus, & Freediving – #185

Robert Lee is a resident fellow in Law, Science, & Technology at Stanford University, an innovation advisor at Singularity University, and an instructor with Performance Freediving. He has a JD/MBA from UC Berkeley, and a BS in Biochemistry & BA in philosophy from Yale University, and has served in a number of roles throughout Silicon Valley, including as CEO of Fly Online, and VP of Intellevate. He has authored a paper published in the Journal of Applied Physiology, is certified as a personal trainer with the American College of Sports Medicine, is a member of both the CA State Bar and US Patent Bar, and has been a guest speaker at entities such as Google, Twitter, UC Berkeley and Stanford business and law schools, as well as the 2014 Bulletproof Biohacking Conference. Why you should listen – Robert comes on Bulletproof Radio, live from the Bulletproof Conference, to discuss the art of respiratory hacking, how to train to breathe differently, the relationship between breathing and emotion and cognitive functioning, and how to mindfulness breathing to everyday life. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Jan 201529min

Bulletproof Radio 2014 in Review! – #184

Bulletproof Radio 2014 in Review! – #184

Thanks for making 2014 a huge year for Bulletproof Radio! There are so many things to be grateful for – hitting #1 overall in the Health category on iTunes, surpassing 10 million downloads, and having incredible guests on the show to share life-changing biohacks and information. I appreciate you for tuning in and subscribing to our audio and video channels - making 2014 our most successful year ever!!! There are so many exciting things to look forward to in 2015, unbelievable guests, top of the line upgrades, and the best in Biohacking. This episode is a recap of the interviews from 2014, and features short clips of the best biohacks, bits of motivation, and pieces of life-upgrading information from every episode. Thanks for making 2014 a huge year for Bulletproof Radio, and enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Dec 20141h 27min

Alan Cash: Upgraded Aging & Living Longer with Oxaloacetate – #183

Alan Cash: Upgraded Aging & Living Longer with Oxaloacetate – #183

Alan Cash is the CEO of Terra Biological LLC, and clinical trials supervisor and medical researcher responsible for the creation of Bulletproof Upgraded Aging Formula. His efforts and persistence in pursuing the research and development of nutritional supplements around the caloric-restriction mimetic compound oxaloacetate have resulted in some profound breakthroughs regarding potential solutions for cognitive decline and anti-aging. Why you should listen: Alan comes on Bulletproof Radio to discuss the latest research on optimal cognitive functioning, steps you can take to produce more mitochondrial mass, the benefits of oxaloacetate supplementation, and what you can do to lessen brain damaging inflammation. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Dec 201425min

Dr. Dwight Jennings: A Live Look at Bite Realignment & How TMJ Impedes Performance #182

Dr. Dwight Jennings: A Live Look at Bite Realignment & How TMJ Impedes Performance #182

Dr. Dwight Jennings is a dentist and TMJ Specialist with expertise in treating orofacial pain, non-surgical orthodontics, and dental orthopedics. Dwight has been practicing neuromuscular dentistry for over 25 years, and has been involved in clinical research and creating new therapies for a large number of medical and developmental disorders that are associated with TMJ, jaw/bite misalignment, and high levels of systemic inflammation caused by the pain neurotransmitter, substance P.   Why you should listen –     In Part 1 of this 2-part podcast, Bulletproof Radio goes live inside Dr. Jenning’s office to discuss how bite alignment can impact everything from pregnancy and infertility, to migraines. head trauma sensitivity, symptoms of aging, and even erectile dysfunction, all while adjusting the contact points of Dave’s teeth and fixing his nocturnal bite guard. You’re definitely going to want to check out the video on this episiode, and don’t forget to check out Part 1! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Dec 201446min

Helen Irlen: Irlen Syndrome, & Visual Stimuli on Brain Performance – #181

Helen Irlen: Irlen Syndrome, & Visual Stimuli on Brain Performance – #181

Helen Irlen has over 40 years of experience as an internationally acclaimed researcher, educator, and therapist in treating visual perception problems. She has served as a professor of Psychology at Cornell, founder and Director of the Adult Learning Disabilities Program at California State University Long Beach, is listed in the Who’s Who in California, Asia and the Pacific Nations, and was named International Woman of the Year in 1999-2000. She has been featured in 60 Minutes (twice!), Good Morning America, BBC Special, ABC Worldwide News with Peter Jennings, and numerous other TV shows around the world talking about the Irlen Method and her patented Irlen Lenses.   Why you should listen –     Helen comes on Bulletproof Radio to discuss Irlen Syndrome, the side effects of LASIK, how technology and different visual stimuli impact brain performance, and how people can get tested for and treat problems with Visual Perception Disorder. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Dec 201421min

James Swanwick: Read a Book a Day, Give Up Alcohol, & Be an Alpha Male - #180

James Swanwick: Read a Book a Day, Give Up Alcohol, & Be an Alpha Male - #180

James Swanwick is an ESPN SportsCenter anchor, co-founder of Crocmedia, and the man behind the James Swanwick Show Podcast and The Alpha Male Club. James has been in print and TV journalism for over 20 years, and has been featured in the Associated Press, The Sun, Loaded Magazine, and many more newspapers and magazines. He authored the ebook Insider Journalism Secrets, and now teaches courses and provides coaching for aspiring journalists looking to break into the industry.   Why you should listen –     James comes on Bulletproof Radio to discuss how to read a book a day, why he gave up drinking alcohol 4 years ago, the difference between being good, excellent, and outstanding, and how to attract the kind of people that you want in your life. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Dec 201459min

Dr. Dwight Jennings: TMJ, Jaw Pain, & Substance P - #179

Dr. Dwight Jennings: TMJ, Jaw Pain, & Substance P - #179

Dr. Dwight Jennings is a dentist and TMJ Specialist with expertise in treating orofacial pain, non-surgical orthodontics, and dental orthopedics. Dwight has been practicing neuromuscular dentistry for over 25 years, and has been involved in clinical research and creating new therapies for a large number of medical and developmental disorders that are associated with TMJ, jaw/bite misalignment, and high levels of systemic inflammation caused by the pain neurotransmitter, substance P.   Why you should listen –     Dr. Dwight comes on Bulletproof Radio to discuss how bite alignment impacts the rest of the body, why jaw pain is a systemic functional health disorder, the difference between orthodontics and dental orthopedics and how to find a specialist that can properly help you with TMJ, and how you can upgrade overall physical performance by adjusting your bite and jaw alignment. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Dec 201455min

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