How the CEO of St. Jude Children's Research Hospital Solves Tough Problems

How the CEO of St. Jude Children's Research Hospital Solves Tough Problems

My interview today is with Dr. James Downing, President and Chief Executive Officer of St. Jude Children's Research Hospital, a leading authority in solving the world's toughest problems. With his visionary leadership, Dr. Downing has spearheaded groundbreaking advancements and transformed the landscape of healthcare.

In our conversation, we delve into the essence of problem-solving and explore the methodologies that drive progress. We uncover Dr. Downing's unique approach to breaking down complex challenges and determining their worthiness. Join us as we unravel the secrets of "blue sky" thinking, from assembling brilliant minds to generating and testing innovative ideas. Discover the key metrics for measuring success and learn how failures can be invaluable teachers.

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This episode is sponsored by: AvePoint

Rapidly reduce costs, improve productivity and make more informed business decisions with AvePoint. With the most advanced platform to optimize SaaS operations and secure collaboration, AvePoint helps you transform your digital workplace and collaborate with confidence. To get started, go to www.avepoint.com and learn how you can advance your digital workplace today.

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Meta Launched a New AI Model and Employees Are Being Ranked by How Much AI They Use

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How Newell Brands Is Operationalizing a High-Performance Culture in the Middle of AI Disruption (CHRO Tracy Platt)

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Preparing a global team for a world that changes by the minute can feel like a race against time, especially when 80% of jobs face major shifts by 2030. In this episode, we tackle the challenge of tur...

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Stanford Just Proved 87% of All Economic Growth Came From Replacing Humans — And AI Is About to Do It Again, Just Slower Than You Think

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April 3, 2026: Two major academic papers dropped today alongside fresh labor market data, and together they paint the clearest picture yet of what AI will actually do to the economy and to work. Stanf...

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Your Company Was Already Too Big. AI Didn't Create the Problem, It Just Ended the Lie.

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April 2, 2026: A landmark MIT study out today challenges the AI job apocalypse — and the data lands somewhere more optimistic than the headlines suggest. Then: the "AI washing" debate exposes a harder...

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