Quadrillions: Sequencing the UK Biobank

Quadrillions: Sequencing the UK Biobank

Half a million genomes. That's how many the UK Biobank has, stored as blood samples in freezers up in Manchester. And in September 2019 they announced a project to sequence every single one of them. It's the obvious next step for the UK Biobank, the research study that began in 2006 and now consists of an enormous biological database: the personal and medical information of its 500,000 volunteers. That data is available to any researcher who applies to use it. But how is this, the biggest whole-genome sequencing project ever, going to work? Who's coughing up the hundreds of millions of pounds... Like this podcast? Please help us by supporting the Naked Scientists

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Eradicating polio

Eradicating polio

This week, we're exploring polio: a highly infectious viral disease that can attack the nervous system and cause paralysis, mainly in young children. Polio has been pushed to the brink of elimination ...

10 Maalis 31min

Immune reprogramming for cancer, and squeaky shoe science

Immune reprogramming for cancer, and squeaky shoe science

Coming up, we explore how CAR-T cell therapy is revolutionising personalised cancer treatment. Plus, how NASA's DART mission tested Earth's asteroid defence, what we are learning about the benefits of...

6 Maalis 31min

Titans of Science: Mike Wooldridge

Titans of Science: Mike Wooldridge

Our Titans of Science series continues with Mike Wooldridge, Ashall Professor of Foundations of Artificial Intelligence at the University of Oxford. He has conducted extensive work in the field of age...

3 Maalis 32min

Brain fats cleared during sleep, and bird poo powered Peru

Brain fats cleared during sleep, and bird poo powered Peru

Today, how the brain harnesses immune cells to clear burned out fats during sleep: does this protect from Alzheimer's disease? Also, the nutrient-rich guano of seabirds that shaped society in ancient ...

27 Helmi 33min

Titans of Science: Jane Carlton

Titans of Science: Jane Carlton

Our Titan of Science this week is leading light in the field of malaria, Jane Carlton. The first to sequence the genome of malaria parasite Plasmodium vivax, she also helped sequence the deadlier Plas...

24 Helmi 30min

Navalny's dart frog poisoning, and cat cancer genomics

Navalny's dart frog poisoning, and cat cancer genomics

This week, we look into the science behind Russian opposition leader Alexei Navalny's death, caused by dart frog poison, and why Russia resorted to such an exotic means of dispatch at all. Also, how c...

20 Helmi 29min

Heart failure: can you mend a broken heart?

Heart failure: can you mend a broken heart?

This week, in partnership with British Heart Foundation, we explore heart failure. Leading experts from the UK's largest independent funder of cardiovascular research tell us about the condition, the ...

17 Helmi 28min

A nasal spray for flu, and is this how life began on Earth?

A nasal spray for flu, and is this how life began on Earth?

This week, we discuss a new antibody-based nasal spray that protects against the flu: how does it work? Plus, the tiny self-replicating molecule that may give clues to the origins of life on Earth, wh...

13 Helmi 30min

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