27. Pharmacology of Drugs with Dr David Nichols

27. Pharmacology of Drugs with Dr David Nichols

A special treat this week as the two titans of psychopharmacology discuss the medicinal chemistry of psychedelics. Dr Nichols is the Founding President of the Heffter Research Institute, an organisation designed to promote research of the highest scientific quality with psychedelics in order to contribute to a greater understanding of the mind leading to the improvement of the human condition, and to alleviate suffering.

Professor Nutt and Dr Nichols answer some burning questions of psychedelic science such as:

What will come to market first, LSD, Psilocybin or MDMA?

Could microdosing be dangerous?

Is there such a thing as DMT tolerance?

David E. Nichols, is currently an Adjunct Professor in the Eshelman School of Pharmacy at the University of North Carolina, Chapel Hill, NC. He is a Distinguished Professor Emeritus at the Purdue University College of Pharmacy, and was the Robert C. and Charlotte P. Anderson Chair in Pharmacology, where he carried out teaching and research for 38 years prior to his retirement in 2012. A major focus of his research was on substances known as hallucinogens, known more popularly as psychedelics. Widely published in the scientific literature and internationally recognized for his research on centrally active drugs, he has studied all of the major classes of psychedelic agents, including LSD and other lysergic acid derivatives, psilocybin and the tryptamines, and phenethylamines related to mescaline. Among scientists, he is recognized as one of the foremost international experts on the medicinal chemistry of psychedelics.

Shulgin

Mescaline

MDMA

LSD

Psilocybin

Entactogen vs Empathogen

Drugs Enforcement Agency

Salvia

Heffter Research Institute

Arthur Heffter

Psilocybin for depression trial

Psilocybin for OCD Yale study

Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors

N,N-dimethyltryptamine and the pineal gland: Separating fact from myth

A Model for the Application of Target-Controlled Intravenous Infusion for a Prolonged Immersive DMT Psychedelic Experience

Fen-phen Weightloss drug

Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin

Become a Drug Science Community Member: https://www.donate.drugscience.org.uk/

Twitter: @ProfDavidNutt @Drug_Science

A Fascinate Productions podcast for Drug Science

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139. Poppers with Adam Zmith

139. Poppers with Adam Zmith

In this episode, we speak with Adam Zmith, podcast producer, writer, and author of Deep Sniff: A History of Poppers and Queer Futures. He describes his motivation behind writing the book, all before diving into the complex history of poppers. By speaking to the policing and regulation of poppers, Zmith explores broader struggles between the queer community and the government, in addition to the necessity for greater harm reduction for poppers. Despite these struggles, he underscores the ways in which queer culture has been shaped by poppers and how, in return, poppers have been shaped by queer culture. Links●      Adam Zmith●      Deep Sniff●      Poppers●      The Log Books●      Switchboard●      Sir Thomas Lauder Brunton●      UK Man Consumes Poppers Accidentally ★ Support this podcast ★

29 Loka 47min

138. Scottish Ambulance Service - Frontline Trauma with John, Joanne and Ryan

138. Scottish Ambulance Service - Frontline Trauma with John, Joanne and Ryan

Join us in this episode as Prof Nutt speaks to John, Joanne, and Ryan of the Scottish Ambulance Service in Glasgow. They explore their backgrounds in the Service and how their work exposed them to challenging situations that caused severe detriment to their mental health. After describing the failings of traditional mental health support for emergency workers, they tell their story of travelling to Peru for an ayahuasca retreat, an eye-opening and profoundly heartening experience. LinksScottish Ambulance ServicesAyahuascaHeroic Hearts Project UKThe ShipiboScottish Psychedelic Research Group ★ Support this podcast ★

16 Loka 53min

137. Cultural History of the Magic Mushroom with Dr Andy Letcher

137. Cultural History of the Magic Mushroom with Dr Andy Letcher

In this episode of the Drug Science podcast, we speak to Dr Andy Letcher, a religious scholar and author of the book Shroom: the Cultural History of the Magic Mushroom. He explores his complimentary background in science and the humanities, depicting how this combination structured his thinking. Noting the religious potential of psychedelic experiences, Letcher links the spiritual with the psychedelic, explaining what he sought to capture in his book and where it has gone since. Finally, he discusses how his interest in transdisciplinary perspectives on psychedelics has coalesced in the University of Exeter’s psychedelic postgraduate courses. PSYCH SYMPOSIUM 2025  LinksShroom: A Cultural History of the Magic MushroomPsychedelics: Mind, Medicine, and CulturePsilocybinSeeking the Magic Mushroom by R. Gordon WassonPsychedelia Britannia: Druids on Drugs ★ Support this podcast ★

2 Loka 43min

136. Parliamentary Office of Science and Technology with Jenny Chapman and Dr Stephen Naulls

136. Parliamentary Office of Science and Technology with Jenny Chapman and Dr Stephen Naulls

Tune into the latest episode of the Drug Science Podcast, where we talk to Jenny Chapman and Dr. Stephen Naulls, researchers at the Parliamentary Office of Science and Technology (POST) and authors of ‘Psychedelic-assisted therapy for mental health: Policy considerations, a briefing for Parliament’ on the state of psychedelic research. They explore the remit of POST in highlighting objective, emerging scientific research, and how psychedelics have come into their focus. With backgrounds in biology and medicine, both Jenny and Stephen stress the interwoven nature of science and policy. Through this intersection, they highlight the policy levers holding psychedelic researchers back and what Parliament and the greater public can take from the POST brief.   Links Parliamentary Office of Science and Technology POST report on Psychedelic-assisted therapy for mental health: Policy considerations, a briefing for Parliament Psychedelic drugs to treat eating disorders Psychedelic drugs to treat post-traumatic stress disorder (PTSD) Psychedelic-assisted therapy to treat anxiety disorders Psychedelic drugs to treat depression Psychedelic-assisted therapy in the treatment of addiction POST Board Fellowship opportunities  POST All Reports Knowledge Exchange Unit – KEU Horizon Scanning Ketamine ★ Support this podcast ★

17 Syys 47min

135. Ethnomycology with Darren Le Baron

135. Ethnomycology with Darren Le Baron

In this episode of the Drug Science Podcast, we speak with Darren Le Baron, an accomplished mycologist and educator. He discusses how his hardships from his upbringing in East London have informed his current work, where he uses horticulture to connect with children at risk of being drawn into crime. He transitions to explore his series Psychedelics in Africa, explaining some of the many links between psychedelics and African culture, both in ancient times and modernity. Throughout, he emphasises the importance of African perspectives and similar indigenous ones, challenging their absence in mainstream psychedelic discourse. LinksDarren Le BaronWho is Darren Le BaronDarren's Instagram   We Are Grow Mushrooms Psilocybin About Kilindi Iyi Psychedelics in Africa: The Untold Story Ibogaine  ★ Support this podcast ★

3 Syys 45min

134. Tribe with Bruce Parry

134. Tribe with Bruce Parry

Join us in this episode as we speak to Bruce Parry, the creator and star of the BBC series Tribe With Bruce Parry. He explains his sharp career change from a Royal Marine to an advocate for indigenous rights, where he’s developed a humble approach to learning from indigenous tribes, defined by listening and witnessing. He talks about his experiences of psychedelics in these contexts, namely ayahuasca, which have vastly shaped his outlook on life. Through this lens, he lends his opinions on topics like ayahuasca tourism and capitalist culture in the psychedelic space.Tribe with Bruce Parry Psilocybin Ayahuasca ★ Support this podcast ★

20 Elo 42min

133. Psychedelic Ethics with Dr Edward Jacobs and Sam Bloomfield

133. Psychedelic Ethics with Dr Edward Jacobs and Sam Bloomfield

In this episode of the Drug Science Podcast, we speak with Sam Bloomfield, founder of PsyEdu, and Dr. Eddie Jacobs, the first person to complete a doctorate in psychedelic ethics. Drawing on their backgrounds in education and ethics, they explore why these perspectives are essential to the evolving field of psychedelics. They also discuss the role of trials, clinics, and retreats within the broader psychedelic ecosystem, highlighting a major blind spot: the vast majority of psychedelic experiences occur outside of these settings. The conversation additionally examines how understandings of medicine often must adapt to the unique nature of psychedelics. Throughout, they underscore the importance of education in driving long-term policy change that ensures safer, more equitable, and more ethical psychedelic access.Psychedelic Training in the UKPsyEdu Beckley FoundationPsychedelic Ethics  Psilocybin MDMA MAPS Public Attitudes to Psilocybin-Assisted Therapy HOPE Statement ★ Support this podcast ★

6 Elo 53min

132. The Fellowship of the River with Dr Joe Tafur

132. The Fellowship of the River with Dr Joe Tafur

In this episode of the Drug Science Podcast, we meet with Dr. Joe Tafur, MD, an integrative Family Physician, curandero, author and speaker. He discusses his book, The Fellowship of the River, exploring the role of spiritual healing in modern healthcare. Within this episode. Tafur further delves into topics such as biological and psychological links to Generational trauma as well as the relationship between spiritual practice and healing.  Dr Joe TafurModern SpiritMedicine SongFellowship of the riverIntro into Therapeutic psychedelicsDepressionPeyoteAyahuascaEmotional dysregulationMamosInner childPsoriasis MigraineAllostatic loadAllostasis EpigeneticsMeditationSupport the Podcast Link ★ Support this podcast ★

23 Heinä 1h 8min

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