Can a Vaccine Cure the World’s Deadliest Cancer?

Throughout December and January, we’re going to be re-airing some of our favorite episodes of the past year and beyond. This list includes interviews that really stuck with me and some others that you guys had tons of feedback and thoughts on … including this one! “A Grand, Unified Theory of Why Americans Are So Unhealthy” originally aired June 18, 2025. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guests: David Kessler and Eric Topol Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

16 Joulu 38min

Throughout December and January, we’re going to be re-airing some of our favorite episodes of the past year and beyond. This list includes interviews that really stuck with me and some others that you guys had tons of feedback and thoughts on … including this one! “The Antisocial Century” originally aired January 10, 2025. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Nick Epley Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

9 Joulu 1h 8min

Throughout December and January, we’re going to be re-airing some of our favorite episodes of the past year and beyond. This list includes interviews that really stuck with me and some others that you guys had tons of feedback and thoughts on … including this one! “How to Be Happy and the Science of Cognitive Time Travel” originally aired August 9, 2024. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Laurie Santos Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

2 Joulu 1h 5min

One of my favorite theories about the modern world is the idea that culture is "stuck." Whether the decline of ornamentation in modern architecture, or the fact that every corporate logo looks the same now, or the fact that Gen Z's favorite television was all made in the 1990s and 2000s, or the sequel fetish in Hollywood, or the theory that old music is eating new music on Spotify, the evidence of cultural stagnation abounds. But is there one grand theory that explains all of it? The psychologist and writer Adam Mastroianni thinks so. He joins Derek to discuss. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Adam Mastroianni Producers: Devon Baroldi Links:https://www.slowboring.com/p/the-hidden-cause-of-cultural-stagnationhttps://www.experimental-history.com/p/the-decline-of-deviancehttps://www.astralcodexten.com/p/whither-tartariahttps://www.theatlantic.com/ideas/archive/2021/12/america-innovation-film-science-business/620858/https://www.theatlantic.com/ideas/archive/2021/12/america-really-running-out-original-ideas/621055/https://www.theatlantic.com/culture/2025/11/blank-space-book-excerpt-culture/685037/ Learn more about your ad choices. Visit podcastchoices.com/adchoices

25 Marras 58min

The University of California San Diego is one of the best public colleges in America. So it was fairly shocking when the school released a report on the steep decline in academic preparedness of its freshman. The number of incoming students in need of remedial math has surged in the past few years. These students did not fail high school math. Many of them got straight A's. Other colleges have seen similar trends: declining mathematical ability from students who aced their high school tests. I think that there are several ways to frame the problem we’re looking at here. One is that American kids can’t do math: That’s the headline of a recent Atlantic article by Rose Horowitch. Another frame, as Kelsey Piper writes in the online magazine The Argument, is that grades have stopped meaning anything. I think that the full story is somewhere in between. The age of grade inflation is also the age of achievement deflation. We are giving more and more A's to students who are learning less and less. There is a lot of talk these days about America moving into a postliterate future. One piece of evidence for this is declining test scores for literacy among students and adults. Fewer people talk about a post-numerate future. The problem here is bigger than UC San Diego. National assessments in the U.S. and even throughout the developed world show that people are getting worse at math. But why? Today we have three guests to help us answer these questions. Rose Horowitch of The Atlantic, Kelsey Piper of The Argument, and Joshua Goodman, an associate professor of education and economics at Boston University. We talk about plummeting math scores for American students, why it’s happening, and why it matters at a moment when carbon-based humans seem to be getting dumber at the very moment that silicon-based machines are getting smarter. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guests: Rose Horowitch, Kelsey Piper and Joshua Goodman Producers: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

21 Marras 54min

Many AI experts believe that some time in the next few years, we will build something close to artificial general intelligence (AGI), a system that can do nearly all valuable cognitive work as well as or better than humans. What happens to jobs, wages, prices, and politics in that world? To explore that question, Derek is joined by Anton Korinek, an economist at the University of Virginia and one of the leading thinkers on the economics of transformative AI. Before he focused on superintelligence, Anton studied financial crises and speculative booms, so he brings a rare mix of macroeconomic skepticism and technological optimism. They talk about quiet AGI versus loud AGI, Baumol’s cost disease, robots, mass unemployment, and what kinds of policies might prevent an “AGI Great Depression” and keep no American left behind. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Anton Korinek Producers: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

18 Marras 58min

Sometimes, the perfect guest to discuss your own writing is ... you. On this special crossover episode, I am interviewed by Ben Smith and Max Tani of Semafor's Mixed Signals podcast about my recent essay, "Everything Is Television." During our conversation, which you can also find on the Mixed Signals feed, we discuss TV, politics, the definition of charisma, and much more. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Hosts: Ben Smith and Max Tani Guest: Derek Thompson Listen to my episode on the Mixed Signals feed HERE. You can find my essay "Everything is Television" HERE. Learn more about your ad choices. Visit podcastchoices.com/adchoices

14 Marras 57min

Youth unemployment is rising. Hiring is freezing up. The housing market is a mess. How did things get so bad for young people in the economy? And are things as bad as they seem? Michael Batnick and Ben Carlson of the Animal Spirits podcast join the show to discuss. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guests: Michael Batnick and Ben Carlson Producers: Devon Baroldi Links: Is this the scariest chart in the world? https://www.derekthompson.org/p/is-this-the-new-scariest-chart-in Learn more about your ad choices. Visit podcastchoices.com/adchoices

12 Marras 52min