38: Does remifentanil cause opioid-induced hyperalgesia?

38: Does remifentanil cause opioid-induced hyperalgesia?

Dr. Jess Hawkins joins the show to discuss the literature pertaining to remifentanil and opioid-induced hyperalgesia. Dr. Hawkins is an anesthesia resident at the Massachusetts General Hospital.

This podcast was recorded as part of the Depth of Anesthesia podcast elective.

Thanks for listening! If you enjoy our content, leave a 5-star review on Apple Podcasts and share our content with your colleagues.

Follow us on Instagram @DepthofAnesthesia and on Twitter (X) @DepthAnesthesia for podcast and literature updates.

Email us at depthofanesthesia@gmail.com with episode ideas or if you'd like to join our team.

Music by Stephen Campbell, MD.

References

Peter Yi, MD, Peter Pryzbylkowski, MD, Opioid Induced Hyperalgesia, Pain Medicine, Volume 16, Issue suppl_1, October 2015, Pages S32–S36, https://doi.org/10.1111/pme.12914

Angst MS, Koppert W, Pahl I, Clark DJ, Schmelz M. Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. Pain. 2003 Nov;106(1-2):49-57. doi: 10.1016/s0304-3959(03)00276-8. PMID: 14581110

Joly V, Richebe P, Guignard B, Fletcher D, Maurette P, Sessler DI, Chauvin M. Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. Anesthesiology. 2005 Jul;103(1):147-55. doi: 10.1097/00000542-200507000-00022. PMID: 15983467

Fletcher D, Martinez V. Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis. Br J Anaesth. 2014 Jun;112(6):991-1004. doi: 10.1093/bja/aeu137. PMID: 24829420

Comelon M, Raeder J, Stuhaug A, et al. Gradual withdrawal of remifentanil infusion may prevent opioid-induced hyperalgesia. Br J Anaesth 2016; 116: 524–30

Jaksot(41)

41: Do pulmonary artery catheters improve outcomes in cardiac surgery?

41: Do pulmonary artery catheters improve outcomes in cardiac surgery?

Dr. Taylor Thomas and Dr. Matt Vanneman join the podcast to discuss the evidence on whether pulmonary artery catheters improve outcomes in cardiac surgery. Dr. Thomas is a dual obstetric and adult car...

26 Loka 202532min

40: Are peripartum opioids safe for breastfeeding mothers?

40: Are peripartum opioids safe for breastfeeding mothers?

Dr. Gopika Hari and Dr. Lana Joudeh join the podcast to discuss the literature on the safety of peripartum opioid use and its implications for breastfeeding. Dr. Hari is an anesthesia resident in the ...

9 Huhti 202541min

39: Should opioid-free anesthesia be implemented? A Pro-Con Debate.

39: Should opioid-free anesthesia be implemented? A Pro-Con Debate.

Dr. Mary Daniels and Dr. Scott Cao join the show to discuss the literature surrounding opioid-free versus opioid-based anesthesia and analgesia techniques. Dr. Scott Cao is currently serving as a chie...

10 Tammi 202525min

37: Should intraoperative dexamethasone be avoided in patients with diabetes mellitus?

37: Should intraoperative dexamethasone be avoided in patients with diabetes mellitus?

Dr. Caroline Andrew and Dr. David Nathan join the show to discuss the literature pertaining to intraoperative administration of dexamethasone. Dr. Caroline Andrew is an anesthesia resident at the Mass...

1 Touko 202441min

36. Does tranexamic acid increase the risk of thromboembolism?

36. Does tranexamic acid increase the risk of thromboembolism?

Dr. Zach Cost and Dr. Tem Bendapudi join the show to discuss the literature pertaining to tranexamic acid and thromboembolic risk. Dr. Zach Cost is an anesthesia resident at the Massachusetts General ...

6 Joulu 20231h

35. Does spinal anesthesia decrease the risk of postoperative delirium?

35. Does spinal anesthesia decrease the risk of postoperative delirium?

Dr. Mark Neuman and Dr. Sam Falkson join the show to discuss the literature around risks of regional versus general anesthesia for postoperative delirium. Dr. Neuman is the founding Director of the Ce...

30 Heinä 202358min

34. Are double lumen endotracheal tubes superior to bronchial blockers?

34. Are double lumen endotracheal tubes superior to bronchial blockers?

Dr. Nick Kumar and Dr. Andy Siemens from the Massachusetts General Hospital anesthesia residency join the show to discuss the literature comparing double lumen endotracheal tubes and bronchial blocker...

2 Huhti 202346min

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