Ep. 147: Basic Immunology in Rare CNS Disorders

Moderator: Gianmarco Abbadessa (Naples, Italy) Guest: Heinz Wiendl (Muenster, Germany) In this episode, Abbadessa and Wiendl delve into the pathogenesis and pathophysiology of rare CNS autoimmune disorders, examining the intricate immune mechanisms that underpin these conditions. Wiendl emphasized the crucial role that a deeper understanding of these processes plays in shaping therapeutic strategies. They explored the distinctive features of disorders such as NMO, MOGAD, autoimmune encephalitis, and immune checkpoint inhibitor-associated neurological diseases, discussing how these differences guide the selection of targeted treatments.