Ep 87 C. diff: Fighting poop with poop

Ep 87 C. diff: Fighting poop with poop

In this week’s episode, we cover a bacterium whose recent emergence and rapid spread has been largely an epidemic of our own making. Clostridium difficile isn’t your typical pathogen - in many cases it’s not even considered a pathogen, just a normal member of our gut microbiota. But when something disrupts our gut microbiota, like antibiotics, C. difficile is given the freedom to spread its wings, wreaking deadly havoc on our bodies especially when it refuses to leave. We explore the characteristics of this bacterium that make it such a terrifying public health threat, delve into its recent-but-not-as-recent-as-you-might-think history, and chat about the current status of C. diff before asking the question, “what can poo do for you?” That’s right, we’re taking this opportunity to talk about one of our all-time favorite medical interventions, fecal microbiota transplantation. Helping us navigate the ins and outs of fecal transplants is Dr. Majdi Osman, Chief Medical Officer at OpenBiome, a nonprofit stool bank that aims to expand access to safe fecal microbiota transplantation and fund research into the human microbiome. By the end of this episode, we think you’ll find yourself in awe at the healing powers of poop.

See omnystudio.com/listener for privacy information.

Jaksot(282)

Special Episode: Adam Kucharski & Proof

Special Episode: Adam Kucharski & Proof

Why do we believe what we believe? Is what we believe the truth? How can we convince others of our beliefs? If you’ve ever found yourself pondering these questions, you know that the answers are rarel...

21 Huhti 50min

Ep 207 Tear Gas: How can a chemical weapon be “humane”?

Ep 207 Tear Gas: How can a chemical weapon be “humane”?

Tear gas is an expected, normalized part of protests today. But its use in international war is banned. How can that be? That’s just one of the questions we investigate in this episode. First, we take...

14 Huhti 1h 15min

Ep 206 Oropouche Virus: More than a smidge worrisome

Ep 206 Oropouche Virus: More than a smidge worrisome

Though discovered relatively recently, Oropouche virus has been making headlines as an emerging vector-borne infectious disease on the rise. Not transmitted by the usual suspects (like ticks and mosqu...

7 Huhti 1h 12min

Ep 205 Cancer Part 4: Where do things stand today?

Ep 205 Cancer Part 4: Where do things stand today?

For the entirety of our species’ history, our approach to cancer has largely been to react, to design new therapies and better combinations of treatments. This energy has certainly been well-spent, bu...

31 Maalis 1h 19min

Ep 204 Cancer Part 3: How do we treat it?

Ep 204 Cancer Part 3: How do we treat it?

A century and a half ago, the list of effective cancer treatments was essentially a single entry: surgery. Today, in 2026, you’d need pages to contain the number of treatments available, and multiple ...

24 Maalis 1h 32min

Special Episode: Lawrence Ingrassia & A Fatal Inheritance

Special Episode: Lawrence Ingrassia & A Fatal Inheritance

For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellula...

17 Maalis 45min

Ep 203 Cancer Part 2: Why does it happen?

Ep 203 Cancer Part 2: Why does it happen?

Each of our cells can become cancerous. It’s an uncomfortable, yet unavoidable truth. Nor is it a truth restricted to our species - cancer is a consequence of complex life. The features that make a ce...

10 Maalis 1h 18min

Ep 202 Cancer Part 1: What is it?

Ep 202 Cancer Part 1: What is it?

Cancer has touched every one of us in some capacity, and learning of a diagnosis inspires many more questions than it answers. In this four-part series on cancer, we aim to lay a foundation of knowled...

3 Maalis 1h 36min

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