#494 C. diff, Diarrhea, the Microbiome, and New Therapies with Dr. Cynthia Sears. Live from Johns Hopkins Grand Rounds

#494 C. diff, Diarrhea, the Microbiome, and New Therapies with Dr. Cynthia Sears. Live from Johns Hopkins Grand Rounds

Dominate C. diff! Learn to distinguish colonization from infection, select first-line therapies, and counsel patients on recurrence prevention and microbiome recovery. We’re joined by IDSA past president and expert on foodborne and intestinal infections, Dr. Cindy Sears (Johns Hopkins University) for a comprehensive update on Clostridioides difficile (C. diff, Cdiff, CDAD, CDI).

Claim CME for this episode at curbsiders.vcuhealth.org!

Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME

Show Segments

  • 00:00 Intro
  • 03:00 Guest bio and hobby
  • 04:25 Case of Charles Fleur Fontaine
  • 06:00 Risk factors and epidemiology
  • 08:00 Antibiotic hierarchy of risk
  • 10:00 Diagnosis, testing strategies
  • 14:00 Defining severity
  • 17:30 Treatment options
  • 20:00 Microbiome recovery strategies
  • 24:00 Probiotics and postbiotics
  • 27:00 Infection control counseling
  • 30:00 C. diff and colon cancer
  • 32:00 Recurrent C. diff strategies
  • 35:00 Why some FMT and bezlotoxumab were discontinued
  • 38:00 Microbiota replacement therapies
  • 43:00 Prophylaxis strategies
  • 45:00 Future therapies and ongoing research
  • 47:00 Audience Q&A
  • 52:00 Outro

Credits

  • Written and Produced by: Matthew Watto, MD, FACP
  • Cover Art and Infographic by:
  • Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP
  • Reviewer: Sai S Achi MD,MBA,FACP
  • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
  • Technical Production: PodPaste
  • Guest: Cynthia Sears MD

Disclosures

Dr. Sears reports no relevant financial disclosures. Dr. Williams financial relationships disclosed include a Merck grant or research support. This relationship has not ended.

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#498 Opioid Withdrawal with Dr. Ashish Thakrar

#498 Opioid Withdrawal with Dr. Ashish Thakrar

Grow your management tools for opioid withdrawal in the hospital. Investigate how to decide between methadone and buprenorphine, additional medications to manage symptoms and how and when to use short-acting opioids for management of withdrawal. We’re joined by Ashish Thakrar, MD at the University of Pennsylvania.  Claim CME for this episode at curbsiders.vcuhealth.org! By listening to this episode and completing CME, this can be used to count towards the new DEA 8-hr requirement on substance use disorders education. Episodes | Subscribe | Spotify | iTunes | CurbsidersAddictionMed@gmail.com | CME! Show Segments Intro, disclaimer, guest bio Guest one-liner Case from Kashlak; Definitions Symptoms of opioid withdrawal Medications for the management of opioid withdrawal Buprenorphine precipitated withdrawal Starting Buprenorphine: Experiences and Strategies  Titrating Methadone: Dosage and Adjuncts Adjunctive short-acting opioids Emerging Trends in Drug Supply: Xylazine and Medetomidine Outro  Credits Producer, Show Notes: Zina Huxley-Reicher Infographics: Zina Huxley-Reicher MD and Zoya Surani Hosts: Carolyn Chan, MD MHS, Zina Huxley-Reicher MD, Shawn Cohen, MD Reviewer: Payel Jhoom Roy, MD, MSc Showrunner: Carolyn Chan, MD, MHS Technical Production: PodPaste Guest: Ashish Thakrar, MD MHSP Sponsor: Mint Mobile  Shop plans at MINTMOBILE.com/CURB Sponsor: Freed Use code: CURB50 to get $50 off your first month when you subscribe! Sponsor: FIGS  We’ve teamed up with FIGS, and now Curbsiders listeners can get 15% off. Just go to WearFIGS.com and use code FIGSRX.

15 Syys 1h 17min

#497 Methamphetamine Use Disorder: Tailoring and Ramping up Management with Dr. Phillip Coffin

#497 Methamphetamine Use Disorder: Tailoring and Ramping up Management with Dr. Phillip Coffin

In this high-yield episode of Curbsiders Addiction Medicine, we dive deep into a practical and compassionate approach to caring for patients using methamphetamines and/or living with methamphetamine use disorder. We explore the latest pharmacologic options, harm reduction strategies, contingency management, and innovative ideas for monitoring and supporting patients. Whether you’re in primary care or other subspecialty settings, this episode is packed with pearls for every clinician with our amazing guest, Dr. Phillip Coffin, Director of the Center on Substance Use and Health in the SFDPH.  Claim CME for this episode at curbsiders.vcuhealth.org! By listening to this episode and completing CME, this can be used to count towards the new DEA 8-hr requirement on substance use disorders education. Episodes | Subscribe | Spotify | iTunes | CurbsidersAddictionMed@gmail.com | CME! Credits Producer/Script Writer/Show Notes: Era Kryzhanovskaya, MD Infographic and Cover Art: Zoya Surani Hosts: Carolyn Chan, MD. MHS and Era Kryzhanovskaya, MD Reviewer: Sarah Leyde MD Showrunner: Carolyn Chan, MD, MHS Technical Production: PodPaste Guest: Dr. Phillip Coffin Show Segments Intro, disclaimer, guest bio Guest one-liner Case from Kashlak; Definitions Four-tier approach to taking care of patients with methamphetamine use/use disorder Medications for treatment Psychosocial treatment Harm reduction New horizons in treatment  Outro Sponsor: Locumstory Learn about locums and get insights from real-life physicians, PAs and NPs at Locumstory.com Sponsor: Panacea Visit panaceafinancial.com and Panacea’s Resource Library for free student loan articles, guides, and webinars built to help you make informed decisions. Sponsor: Grammarly  Download Grammarly for free at Grammarly.com/PODCAST

8 Syys 1h 2min

REBOOT: #457 Cold and Flu Season: Upper Respiratory Infections

REBOOT: #457 Cold and Flu Season: Upper Respiratory Infections

We have a classic episode for you. Dive deep into upper respiratory viral infections with Dr Amber Bird, MD (Penn).  Feel confident on when to order testing, recommend symptom relieving treatments, and avoid unnecessary antibiotics. Sponsors Continuing Education Company Curbsiders listeners: use promo code Curb30 for 30% off all online courses and webcasts. Head to CMEmeeting.org/curbsiders to learn more. FIGS Curbsiders listeners can get 15% off. Just go to WearFIGS.com and use code FIGSRX. Freed Use code: CURB50 to get $50 off your first month when you subscribe at getfreed.ai

1 Syys 1h 5min

#496 Hotcakes: Cannabidiol (CBD)-induced liver injury, IV iron for HFrEF, bedtime BP meds, Carpal Tunnel Syndrome & RA, & Finerenone for HFpEF

#496 Hotcakes: Cannabidiol (CBD)-induced liver injury, IV iron for HFrEF, bedtime BP meds, Carpal Tunnel Syndrome & RA, & Finerenone for HFpEF

Join us as we review recent practice-changing articles on cannabidiol (CBD)-induced liver injury, IV iron for HFrEF, bedtime administration of blood pressure meds, carpal tunnel syndrome & rheumatoid arthritis , & FDA approval of finerenone for HFpEF. Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Rahul Ganatra (@rbganatra), Nora Taranto (@norataranto) and Matt Watto (@doctorwatto). Claim CME for this episode at curbsiders.vcuhealth.org! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Credits Written and Hosted by: Rahul Ganatra MD, MPH; Nora Taranto MD, Paul Williams, MD, FACP, Matthew Watto MD, FACP Cover Art: Rahul Ganatra MD, MPH Reviewer: Emi Okamoto, MD Technical Production: Pod Paste Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Show Segments Intro, disclaimer CBD-induced liver injury IV Iron in HFrEF Bedtime administration of BP medications Carpal tunnel syndrome and RA FDA approves Finerenone for HFpEF Outro Sponsor: Permanente Want to join thousands of physicians who've made TPMG their career destination? Discover more at northerncalifornia.permanente.org

25 Elo 58min

#495 Fungal Infections -Histo/Blasto/Cocci with Dr. Andrej Spec

#495 Fungal Infections -Histo/Blasto/Cocci with Dr. Andrej Spec

Why we need to stop calling them “endemic” mycoses & more fungi fun! Feeling muddled about endemic mycoses? We tackle the clinical presentation of diseases like histoplasmosis, blastomycosis, and coccidioidomycosis, the importance of testing, and how to diagnose fungal infections  with our esteemed guest Dr. Andrej Spec, MD! Claim CME for this episode at curbsiders.vcuhealth.org! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Show Segments Introduction and icebreaker,  Fish Club?!  00:00 Case 1 from Kashlak 07:27 Diagnostic framework for dimorphic fungi 11:58 Imaging presentations for fungal pneumonia, diagnostic schemas 18:23 Testing options 27:48 Treatment options 35:44 Dimorphic Fungi Mnemonics 45:50 Retail testing for mold 48:47 Case 2 from Kashlak 56: 42 Takeaways and Conclusions 1:05:19 Credits Producer, Writer, Show Notes:  Beth “Garbs” Gasperlin MD Infographic and Cover Art: Zoya Surani Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP,  Beth Gasperlin MD   Reviewer: Leah Witt Gaspard MD Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Andrej Spec MD Disclosures Dr. Spec reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.  Sponsor: Quince Go to Quince.com/curb for free shipping on your order and three hundred and sixty-five -day returns. Sponsor: Continuing Education Company  Special offer for Curbsiders listeners: Save 30% on all online courses and live webcasts with promo code CURB30. Visit www.CMEmeeting.org/curbsiders to explore all offerings and claim your discount. Sponsor: Freed Use code: CURB50 to get $50 off your first month when you subscribe!

18 Elo 1h 12min

Bonus: Hypermobility Q&A with Bendy Bodies Dr. Linda Bluestein

Bonus: Hypermobility Q&A with Bendy Bodies Dr. Linda Bluestein

In this special bonus episode, Dr. Linda Blustein (Bendy Bodies https://bit.ly/m/BendyBodies) addresses listener questions about Ehlers-Danlos syndrome (EDS) and hypermobility spectrum disorders. 00:00 – Introduction 00:59 – Can PCPs diagnose hEDS without a geneticist? 03:19 – Limitations of the Beighton Score 05:40 – 2017 hEDS criteria & upcoming revisions 10:29 – How to find a knowledgeable provider 12:52 – SVT vs POTS in a patient with EDS family history 19:53 – How to ask your provider if they’re comfortable treating dysautonomia 22:17 – MTHFR variants and hEDS 29:23 – Celiac, gluten sensitivity & EDS 31:48 – Food allergy vs sensitivity testing 34:11 – Lipoedema and hypermobility 39:00 – LDN, Ketotifen, and Cromolyn 43:41 – Medication sensitivity in EDS/POTS/MCAS patients 45:47 – Wrap up and resources ​FIGS Get 15% off your first order at wear figs.com with the code FIGSRX Locumstory ​Locumstory.com is simply a free, unbiased educational resource about locum tenens Grammarly Download Grammarly for free at Grammarly.com/PODCAST

7 Elo 51min

REBOOT: #452 NAFLD/MASLD with Dr. Elliot Tapper

REBOOT: #452 NAFLD/MASLD with Dr. Elliot Tapper

We have a classic Curbsiders episode for you. Expert guest Dr. Elliot Tapper (@ebtapper) shares his framework for approaching NAFLD/MASLD and the treatment tools he recommends including lifestyle modifications and medications.

4 Elo 1h 14min

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