Journal Review in Thoracic Surgery: The ESOPEC Trial

Journal Review in Thoracic Surgery: The ESOPEC Trial

Listen as we discuss the highly-awaited ESOPEC trial, which examines treatment regimens for esophageal and EGJ adenocarcinoma. Wildly impress your thoracic attendings or peers with your nuanced knowledge! FLOT who? You’ll know. Pull out the paper and listen along!

Learning Objectives:
-Discuss the patient population in the ESOPEC trial
-Discuss the main differences between the ESOPEC trial and the CROSS trial
-Describe the main drawbacks between FLOT and the CROSS regimen.

Hosts:
Chloe Hanson MD, Brian Louie MD, and Peter White MD

Referenced Material

https://www.nejm.org/doi/full/10.1056/NEJMoa2409408

Hoeppner J, Brunner T, Schmoor C, Bronsert P, Kulemann B, Claus R, Utzolino S, Izbicki JR, Gockel I, Gerdes B, Ghadimi M, Reichert B, Lock JF, Bruns C, Reitsamer E, Schmeding M, Benedix F, Keck T, Folprecht G, Thuss-Patience P, Neumann UP, Pascher A, Imhof D, Daum S, Strieder T, Krautz C, Zimmermann S, Werner J, Mahlberg R, Illerhaus G, Grimminger P, Lordick F. Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer. N Engl J Med. 2025 Jan 23;392(4):323-335. doi: 10.1056/NEJMoa2409408. PMID: 39842010.

https://www.nejm.org/doi/full/10.1056/NEJMoa1112088

van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A; CROSS Group. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012 May 31;366(22):2074-84. doi: 10.1056/NEJMoa1112088. PMID: 22646630.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32557-1/abstract

Al-Batran SE, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S, Kopp HG, Mayer F, Haag GM, Luley K, Lindig U, Schmiegel W, Pohl M, Stoehlmacher J, Folprecht G, Probst S, Prasnikar N, Fischbach W, Mahlberg R, Trojan J, Koenigsmann M, Martens UM, Thuss-Patience P, Egger M, Block A, Heinemann V, Illerhaus G, Moehler M, Schenk M, Kullmann F, Behringer DM, Heike M, Pink D, Teschendorf C, Löhr C, Bernhard H, Schuch G, Rethwisch V, von Weikersthal LF, Hartmann JT, Kneba M, Daum S, Schulmann K, Weniger J, Belle S, Gaiser T, Oduncu FS, Güntner M, Hozaeel W, Reichart A, Jäger E, Kraus T, Mönig S, Bechstein WO, Schuler M, Schmalenberg H, Hofheinz RD; FLOT4-AIO Investigators. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019 May 11;393(10184):1948-1957. doi: 10.1016/S0140-6736(18)32557-1. Epub 2019 Apr 11. PMID: 30982686.

***Fellowship Application Link: https://forms.gle/PQgAvGjHrYUqAqTJ9

Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.

If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

Jaksot(500)

Resident Professional Development Time: When to Take it, How to Fund It, and How to Make it Count

Resident Professional Development Time: When to Take it, How to Fund It, and How to Make it Count

Research years. Professional development time. Career exploration.Whatever you call it, stepping out of clinical residency can feel confusing, intimidating, and oddly hard to plan for. In this episode...

12 Helmi 38min

Clinical Challenges in Transplant Surgery: Deceased Donor Abdominal Recovery - A Step-by-Step Guide

Clinical Challenges in Transplant Surgery: Deceased Donor Abdominal Recovery - A Step-by-Step Guide

Abdominal organ procurement is a high-stakes operation that blends anatomy, speed, and coordinated teamwork. In this Behind the Knife episode, the UNMC transplant team walks through the practical “how...

9 Helmi 47min

Clinical Challenges in Bariatric Surgery: Integration of Obesity Management Medications (OMMs)

Clinical Challenges in Bariatric Surgery: Integration of Obesity Management Medications (OMMs)

What happens when the world of GLP-1s collides with the operating room? Today, we’re diving into the new era of obesity care. Hosts·       Matthew Martin, trauma and bariatric surgeon at the Universit...

5 Helmi 32min

Parental Support: Policies In Surgery Training

Parental Support: Policies In Surgery Training

In surgical residency, cases are long, expectations are high, and patient care always comes first. But then you become a parent, and suddenly you’re navigating pregnancy risk, parental leave, and lact...

2 Helmi 52min

Parental Support: The 5-in-6 Pathway - Flexibility in Surgical Residency Training

Parental Support: The 5-in-6 Pathway - Flexibility in Surgical Residency Training

You’re in the middle of surgical residency, and you realize you need more than a few weeks away from clinical responsibilities. Maybe you need more time to be a parent, recover from an illness, care f...

29 Tammi 41min

Operative Standards for Cancer Surgery Series: Papillary Thyroid Cancer

Operative Standards for Cancer Surgery Series: Papillary Thyroid Cancer

This new mini-series on Behind the Knife will delve into the technical aspects of the Operative Standards for Cancer Surgery, developed through the American College of Surgeons Cancer Research Program...

26 Tammi 32min

Behind the Knife ABSITE 2026 - Quick Hits 4

Behind the Knife ABSITE 2026 - Quick Hits 4

Behind the Knife ABSITE 2026 – Up-to-date and high yield learning to help you DOMINATE the exam.Don’t forget to check out our ABSITE Podcast Companion Book available on Amazon: https://www.amazon.com/...

23 Tammi 27min

Journal Review in Trauma Surgery: Getting to the Heart of the Problem - Prehospital Resuscitative Thoracotomy for Traumatic Cardiac Arrest

Journal Review in Trauma Surgery: Getting to the Heart of the Problem - Prehospital Resuscitative Thoracotomy for Traumatic Cardiac Arrest

In resuscitative trauma surgery every second counts. Can time and lives be saved by moving interventions closer to the point of injury? In this episode, we discuss a recent journal article on prehospi...

22 Tammi 50min

Suosittua kategoriassa Koulutus

rss-murhan-anatomia
psykopodiaa-podcast
voi-hyvin-meditaatiot-2
rss-narsisti
adhd-podi
rss-duodecim-lehti
jari-sarasvuo-podcast
leveli
rss-liian-kuuma-peruna
rss-valo-minussa-2
rss-koira-haudattuna
rahapuhetta
rss-niinku-asia-on
salainen-paivakirja
psykologia
ihminen-tavattavissa-tommy-hellsten-instituutti
rss-uskonto-on-tylsaa
rss-luonnollinen-synnytys-podcast
rss-tietoinen-yhteys-podcast-2
rss-arkea-ja-aurinkoa-podcast-espanjasta