TWiV 955: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.

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Links for this episode

• Four things to know about RSV (Gates Foundation)
• The burden of RSV in healthy term-born infants in Europe (The Lancet)
• Diagnostic accuracy of rapid tests for Ebola (CMI)
• Accuracy of self-collected swabs for diagnosis of Monkeypox (CID)
• Tecovirimat is effective against human monkeypox virus in vitro (Nature)
• Acute and postacute sequelae associated with SARS-CoV-2 reinfection (NatureMedicine)
• SARS-CoV-2 infection and recovery in lung transplant recipients (Transplant Infectious Diseases)
• Effectiveness of third COVID-19 vaccination during pregnancy (Nature Communications)
• Maternal antibody response and transplacental transfer following infection or vaccination (CID)
• Impact of community masking on COVID-19 (Science)
• Lifting universal masking in schools (NEJM)
• Bebtelovimab fact sheet for providers (FDA)
• Effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 (medRxiv)
• Effectiveness of Sotrovimab and Molnupiravir for prevention of severe COVID-19 outcomes (BMJ)
• Early adoption of Anti–SARS-CoV-2 pharmacotherapies among US veterans (JAMA)
• PAXLOVID patient eligibility screening checklist (FDA)
• Viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants (medRxiv)
• Monoclonal antibodies for treatment of SARS-CoV-2 during pregnancy (Annals of Internal Medicine)
• Remdesivir fact sheet for providers (Veklury)
• Twice daily oral zinc in the treatment of patients with COVID-19 (CID)
• Cognitive deficits in long COVID-19 (NEJM)
• Severe Neuro-COVID associated with peripheral immune signatures, autoimmunity and neurodegeneration (Nature Communications)
• Long-lasting symptoms after an acute COVID-19 Infection (JAMA)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin's treatment guide (pdf)
• Letters read on TWiV 955
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv