TWiV 984: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi's cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don't, COVID-19 and airborne transmission: science rejected, lives lost. can society do better, what were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic, a randomized trial comparing Omicron-containing boosters with the original COVID-19 vaccine mRNA-1273, SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster, the impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England, intra-host evolution provides for the continuous emergence of SARS-CoV-2 variants, real-world use of Nirmatrelvir–Ritonavir in outpatients with COVID-19 during the era of Omicron variants including BA.4 and BA.5 in Colorado, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, and guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19.

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Links for this episode

• The political polarization of COVID-19 treatments in the United States (PNAS)
• Seven alternatives to evidence-based medicine (BMJ)
• Malawi's cholera death toll crosses 1,300 (CBC)
• Impact of coronavirus infections on pediatric patients (JHI)
• Maternal mRNA COVID-19 vaccination during pregnancy (BMJ)
• Yes, masks reduce the risk of spreading COVID (TVO)
• COVID-19 and airborne transmission (IDSA)
• What were the reasons for resistance to recognizing airborne transmission (IJIE)
• Comparing Omicron-containing boosters with COVID-19 vaccine mRNA-1273 (medRxiv)
• SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster (bioRxiv)
• The impact of SARS-CoV-2 vaccine dose separation and targeting (Nature)
• Intra-host evolution provides for the emergence of SARS-CoV-2 variants (ASM)
• Real-world use of nirmatrelvir–ritonavir in outpatients with COVID-19 (The Lancet)
• Viral rebound in hospitalized patients with COVID-19 receiving oral antivirals (The Lancet)
• Guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19 (CID)
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin's treatment guide (pdf)
• Letters read on TWiV 984
• Don't crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv