Alzheimer’s Can Be Prevented & Reversed: Drs. Dean & Ayesha Sherzai On Optimizing Brain Health

Alzheimer’s Can Be Prevented & Reversed: Drs. Dean & Ayesha Sherzai On Optimizing Brain Health

While other major diseases are in decline, deaths from Alzheimer's have increased dramatically in recent decades. In fact, Alzheimer's is currently the 6th (and due to massive under-reporting may be as high as the 3rd ) leading cause of death in the United States. Right now, over 47 million people worldwide currently live with Alzheimer's. By 2050, it's predicted this form of dementia will plague 135.5 million people across the globe. This disease has become so pervasive, chances are you have been directly or indirectly impacted through an afflicted loved one. If so, then you know first hand the devastation it creates. You've seen it's ravaging effects. Perhaps you've even shouldered the immense emotional, financial and social burden it produces — and the hopelessness it provokes. The sad truth is that Alzheimer's is a condition that Western medicine has utterly failed to combat, let alone cure. Simply put, there is no pharmaceutical or surgical treatment to effectively prevent or reverse this savage and cataclysmic condition. But there is hope. Alzheimer's isn't a genetic inevitability. A diagnosis doesn't have to come with a death sentence. In fact, according to this week's guests, 90% of all Alzheimer's cases can be prevented. And for the 10% with a strong genetic risk for cognitive decline, the disease can be delayed for ten to fifteen years. These are not estimates. Nor are they wishful thinking. They are conclusions based on rigorous science performed by neurologists Drs. Dean and Ayesha Sherzai. Co-directors of the Brain Health and Alzheimer's Prevention Program at Loma Linda University Medical Center, Team Sherzai is the dynamic husband and wife duo behind the largest clinical and observational study on Alzheimer's to date as well as the co-authors of The Alzheimer's Solution*, a must-read primer that details their extensive research, chronicles the remarkable results they have experienced working with patients first-hand, and sets forth the first ever comprehensive program to prevent Alzheimer's disease, improve cognitive function, and ultimately optimize long-term brain health. The solution might surprise you. It's not due to a breakthrough in surgical procedures. It's not the result of new pharmaceutical trials. Instead, as far fetched as it may sound, the answer is rooted in fundamental, simple changes in nutrition and lifestyle. Dr. Dean Sherzai, M.D., PhD., completed his medical and neurology residencies at Georgetown University with a subsequent fellowship in neurodegenerative diseases at the National Institutes of Health, followed by a second fellowship in Dementia and Geriatrics at the University of California, San Diego. He also holds two Masters Degrees; in advanced sciences at UCSD and a Masters in public health from Loma Linda University. Finally, he has received a Ph.D. in Healthcare leadership at Loma Linda/Andrews University. Dr. Ayesha Sherzai, M.D., completed her medical residency at Loma Linda University. She subsequently completed a residency in preventive medicine and neurology and thereafter received a fellowship in vascular neurology from Columbia University, and is currently finalizing her PhD in Epidemiology at Loma Linda University. Ayesha also has a culinary degree, giving her a unique understanding of nutrition as a powerful tool for disease prevention. Peace + Plants, Rich

Episoder(969)

Reclaim Your Excellence: The Path To A Meaningful & Joyous Life w/ Brad Stulberg

Reclaim Your Excellence: The Path To A Meaningful & Joyous Life w/ Brad Stulberg

Brad Stulberg is a bestselling author, executive coach, and one of my favorite thinkers on sustainable high performance. This conversation explores the dualities in personal development, discipline and self-compassion, striving and surrender, intensity and joy. We discuss the "humble badass" archetype, building resilient identities, why curiosity is the skeleton key, and excellence as an antidote to alienation. Along the way, Brad gets vulnerable about the childhood wounds that still drive his ambition—and I share my own. Amidst the chaos of self-help, Brad remains a principled voice of reason. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: Birch: For 20% off ALL mattresses👉🏼BirchLiving.com/richroll Momentous: High-caliber human performance products for sleep, focus, longevity, and more. For listeners of the show, Momentous is offering up to 35% off your first order👉🏼https://bit.ly/LiveMomentous2025 BetterHelp: Get 10% OFF the first month👉🏼https://www.betterhelp.com/richroll Rivian: Electric vehicles that keep the world adventurous forever👉🏼https://www.rivian.com Squarespace: Use code RichRoll to save 10% off your first order of a website or domain👉🏼http://www.squarespace.com/RichRoll Check out all of the amazing discounts from our Sponsors👉🏼https://www.richroll.com/sponsors  Find out more about Voicing Change Media at https://www.voicingchange.media and follow us @voicingchange

19 Jan 2h 3min

Cognitive Scientist Maya Shankar On Navigating Unexpected Life Changes, The Neuroscience Of Identity, & How To Unlock Your Next Self

Cognitive Scientist Maya Shankar On Navigating Unexpected Life Changes, The Neuroscience Of Identity, & How To Unlock Your Next Self

Dr. Maya Shankar is a cognitive scientist, host of the podcast “A Slight Change of Plans,” and author of “The Other Side of Change.” This conversation explores the challenge of navigating involuntary change, whether it's injury, loss, or a future that suddenly collapses. We discuss identity and attachment, the illusion of control, why our brains resist uncertainty, the end of history illusion, rumination, and practical tools to help us see change not as a burden—but as a revelation. Maya also opens up about her own identity crises, a career-ending injury at 15, and later pregnancy losses that forced her to confront who she was beyond her deepest aspirations. Change is coming for all of us, whether we like it or not. Maya's goal is to give you the companion you need along the way. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: Go Brewing: Use the code Rich Roll for 15% OFF👉🏼https://www.gobrewing.com AG1: Get their best offer ever – Welcome Kit, Omega 3's, D3+K2, Flavor Sampler, plus AGZ sleep supplement FREE ($126 in gifts)👉🏼https://www.drinkAG1.com/richroll Rivian: Electric vehicles that keep the world adventurous forever👉🏼https://www.rivian.com WHOOP: The all-new WHOOP 5.0 is here! Get your first month FREE👉🏼https://www.join.whoop.com/Roll Check out all of the amazing discounts from our Sponsors👉🏼https://www.richroll.com/sponsors  Find out more about Voicing Change Media at https://www.voicingchange.media and follow us @voicingchange

15 Jan 2h 6min

Dr. Will Bulsiewicz: Heal Your Gut, Reduce Inflammation & Optimize Your Microbiome

Dr. Will Bulsiewicz: Heal Your Gut, Reduce Inflammation & Optimize Your Microbiome

Dr. Will Bulsiewicz is a gastroenterologist, one of the world's foremost authorities on the gut microbiome, and author of “Plant Powered Plus.” This conversation explores the gut-immune connection as the root determinant of chronic inflammation—the silent driver behind three out of five deaths. We discuss the four nutritional workhorses, why your microbiome is nocturnal, and what happens when you eat after dark. Dr. B also opens up about a decade-long estrangement from his father—an unexpected reminder that healing isn't always biological. Sometimes it's emotional. This is our third exchange together. Our best yet. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: Go Brewing: Use the code Rich Roll for 15% OFF👉🏼https://www.gobrewing.com Prolon: Get 15% OFF plus a FREE bonus gift👉🏼https://www.prolonlife.com/richroll OneSkin: Get started today with 15% off using code RICHROLL👉🏼https://www.oneskin.co/ AG1: Get their best offer ever – Welcome Kit, Omega 3's, D3+K2, Flavor Sampler, plus AGZ sleep supplement FREE ($126 in gifts)👉🏼https://www.drinkAG1.com/richroll The Sprouting Company: Get 10% off and a free copy of “The Sprout Book” with code RICHROLL👉🏼https://www.thesproutingcompany.com/pages/richroll Airbnb: Your home might be worth more than you think. Find out how much👉🏼https://www.airbnb.com/host  Check out all of the amazing discounts from our Sponsors👉🏼https://www.richroll.com/sponsors  Find out more about Voicing Change Media at https://www.voicingchange.media and follow us @voicingchange

12 Jan 2h 27min

Mark Manson On Vanity Goals, Self-Sabotage & How To Actually Change Your Life

Mark Manson On Vanity Goals, Self-Sabotage & How To Actually Change Your Life

Mark Manson is the author of The Subtle Art of Not Giving a F*ck and host of the Solved podcast. Back for his third appearance (eps. 476, 882), we skip the backstory and pull questions from a fishbowl. We discuss vanity goals versus values-aligned goals, why procrastination is really about emotional avoidance, the trap of people-pleasing, how to distinguish intuition from impulse, and the delusion of passive manifestation. I also share my own shifting perspectives on positive thinking and the dissolution of self. Mark is the anti-guru. And this conversation is your New Year intervention. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: Seed: Use code RICHROLL20 for 20% OFF your first order👉🏼https://www.seed.com/RichRoll  BetterHelp: Get 10% OFF the first month👉🏼https://www.betterhelp.com/richroll Momentous: High-caliber human performance products for sleep, focus, longevity, and more. For listeners of the show, Momentous is offering up to 35% off your first order👉🏼https://www.livemomentous.com/richroll WHOOP: The all-new WHOOP 5.0 is here! Get your first month FREE👉🏼https://www.join.whoop.com/Roll Check out all of the amazing discounts from our Sponsors👉🏼https://www.richroll.com/sponsors Find out more about Voicing Change Media at https://www.voicingchange.media and follow us @voicingchange

5 Jan 1h 48min

Best of 2025 (Part Two): The Year’s Most Enduring Insights

Best of 2025 (Part Two): The Year’s Most Enduring Insights

The finale is here. Let's close this thing out. Part 2 explores courage, honesty, creativity, relationships, and balance. Bravery. Addiction. Love. Mastery. And why fulfillment doesn't require sacrifice. It's been fun putting this auditory yearbook together. I hope you found these two episodes uplifting and inspiring. Thanks for the love and support. This podcast has been an amazing journey. I'm grateful you're on it with me. Here's to 2026. Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: Go Brewing: Use the code Rich Roll for 15% OFF👉🏼https://www.gobrewing.com On: High-performance shoes & apparel crafted for comfort and style👉🏼https://www.on.com/richroll AG1: Get their best offer ever – Welcome Kit, Omega 3's, D3+K2, Flavor Sampler, plus AGZ sleep supplement FREE ($126 in gifts)👉🏼https://www.drinkAG1.com/richroll Whoop: The all-new WHOOP 5.0 is here! Get your first month FREE👉🏼https://www.join.whoop.com/Roll LMNT: Get a free LMNT Sample Pack with any purchase👉🏼https://www.drinklmnt.com/richroll  Birch: For 27% off ALL mattresses👉🏼BirchLiving.com/richroll Check out all of the amazing discounts from our Sponsors👉🏼https://www.richroll.com/sponsors  Find out more about Voicing Change Media at https://www.voicingchange.media and follow us @voicingchange

29 Des 20251h 51min

Best of 2025 (Part One): Conversations That Shaped Us

Best of 2025 (Part One): Conversations That Shaped Us

Happy holidays from the RRP mothership. Another year in the rearview. Time for what's become one of my favorite traditions, our annual “Best Of.” 12 years running now. This year was packed with an astonishing array of guests—too many to feature here. Part 1 revisits the year's most powerful moments: longevity science, neuroplasticity, happiness research, emotional regulation, consciousness, and what it actually takes to change. I'm filled with gratitude for our guests, my team, and most of all—for you. I don't take your attention and support for granted. Here's to growing together in 2026. Show notes + MORE Watch on YouTubeNewsletter Sign-Up Today’s Sponsors: On: High-performance shoes & apparel crafted for comfort and style 👉🏼https://www.on.com/richroll AG1: Get their best offer ever – Welcome Kit, Omega 3's, D3+K2, Flavor Sampler, plus AGZ sleep supplement FREE ($126 in gifts) 👉🏼https://www.drinkAG1.com/richroll Prolon: Get 15% OFF plus a FREE bonus gift 👉🏼https://www.prolonlife.com/richroll Calm: Get 40% off a Calm Premium subscription 👉🏼https://www.calm.com/richroll Momentous: High-caliber human performance products for sleep, focus, longevity, and more. For listeners of the show, Momentous is offering up to 35% off your first order 👉🏼https://www.livemomentous.com/richroll Roka: Unlock 20% OFF your order with code RICHROLL 👉🏼https://www.ROKA.com/RICHROLL Rivian: Electric vehicles that keep the world adventurous forever 👉🏼https://www.rivian.com Check out all of the amazing discounts from our Sponsors 👉🏼https://www.richroll.com/sponsors  Find out more about Voicing Change Media at https://www.voicingchange.media and follow us @voicingchange

22 Des 20251h 46min

Kevin Hall, PhD On The Science & Politics of Weight Loss

Kevin Hall, PhD On The Science & Politics of Weight Loss

Kevin Hall, Ph.D., is a physicist-turned-nutrition scientist and author of "Food Intelligence: The Science of How Food Both Nourishes and Harms Us. "This conversation explores why diets fail, the truth behind the "slow metabolism" myth, how ultra-processed foods hijack our biology, and why the 800-pound gorilla driving the obesity epidemic isn't willpower—it's our toxic food environment. He also opens up about his decision to leave the NIH after 20 years due to political interference with his research. Kevin is an honest actor, always trying to set matters to rights amidst a hurricane of nutritional misinformation. Enjoy!  Show notes + MOREWatch on YouTubeNewsletter Sign-Up Today’s Sponsors: On: High-performance shoes & apparel crafted for comfort and style👉🏼https://www.on.com/richroll Momentous: High-caliber human performance products for sleep, focus, longevity, and more. For listeners of the show, Momentous is offering up to 35% off your first order 👉🏼https://www.livemomentous.com/richroll Seed: Use code RICHROLL20 for 20% OFF your first order👉🏼https://www.seed.com/RichRoll Roka: Unlock 20% OFF your order with code RICHROLL👉🏼https://www.ROKA.com/RICHROLL BetterHelp: Get 10% OFF the first month 👉🏼https://www.betterhelp.com/richroll Check out all of the amazing discounts from our Sponsors👉🏼https://www.richroll.com/sponsors  Find out more about Voicing Change Media at https://www.voicingchange.media and follow us @voicingchange

18 Des 20251h 58min

Let’s Make The World Wildly Better: Rutger Bregman On Moral Ambition

Let’s Make The World Wildly Better: Rutger Bregman On Moral Ambition

Rutger Bregman is a Dutch historian, bestselling author, and the guy who went viral telling Davos billionaires to pay their taxes. This conversation is a salve for the crisis of meaning percolating through modern life. We explore Rutger's pragmatic antidote—moral ambition—and discuss why a quarter of workers believe their jobs are socially useless, what the abolitionists teach us about coalition-building, and why factory farming may be the ethical abomination future historians judge us for most harshly. Rutger's conviction is rare and infectious. By the end of our conversation, I was so inspired that I committed $25K to his organization’s new US Food System Reform Program, a cause area that is deeply important to me. Final Note: Through December 31st, every dollar to moralambition.org/food is matched.  I hope you’ll consider joining me today in making a donation to this impactful organization. See the links in our newsletter, on our website, and in our Substack. Let’s lean into our own moral ambition and do something truly meaningful, together. Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: On: High-performance shoes & apparel crafted for comfort and style👉🏼https://www.on.com/richroll Roka: Unlock 20% OFF your order with code RICHROLL👉🏼https://www.ROKA.com/RICHROLL AG1: Get their best offer ever – Welcome Kit, Omega 3's, D3+K2, Flavor Sampler, plus AGZ sleep supplement FREE ($126 in gifts)👉🏼https://www.drinkAG1.com/richroll Bon Charge: Get 15% OFF all my favorite wellness products w/ code RICHROLL👉🏼https://www.boncharge.com BetterHelp: Get 10% OFF the first month👉🏼https://www.betterhelp.com/richroll Squarespace: Use code RichRoll to save 10% off your first order of a website or domain👉🏼http://www.squarespace.com/RichRoll Check out all of the amazing discounts from our Sponsors👉🏼https://www.richroll.com/sponsors Find out more about Voicing Change Media at https://www.voicingchange.media and follow us @voicingchange

15 Des 20252h

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