#72 IGF-1, mTOR, Autophagy Deep Dive

Get Bon Charge products (Code SIIM): https://boncharge.com/siimlandTimestamps:00:00 Intro00:25 Why is creatine the most studied supplement of all time01:45 What does creatine do to your body05:45 Why supplement creatine07:30 Typical creatine dosages09:35 Creatine and sleep deprivation11:45 Bon Charge sponsorship12:36 Creatine and muscle growth16:16 How and when to take creatine18:51 Creatine and strength and power20:26 Creatine and fat loss21:26 Creatine and bone density24:21 Creatine and endurance29:11 Creatine and brain aging37:06 Do you need to take creatine all the time38:21 Is creatine safe for kidneys and hair loss43:51 Do you need to drink more water when taking creatine44:46 Best type of creatine48:16 Creatine and mental health benefitsDr. Darren Candow Instagram: https://www.instagram.com/dr.darrencandow/

2 Mai 53min

Get Bon Charge Infrared Sauna Blanket (Code SIIM): https://boncharge.com/siimlandTimestamps:00:00 Intro00:35 How Kayla interviewed his date for his health04:35 Why Kayla got interested in health09:11 Bon Charge sponsorship09:57 Male vs female longevity19:17 How Kayla is preparing her body for getting a baby29:37 How to support fertility32:17 How many kids is optimal34:17 Protocol for removing toxins and plastics42:22 Total plasma exchange for longevity45:42 Hyperbaric oxygen therapy48:42 What supplements and peptides Kayla takes56:42 Extending female reproductive window01:02:17 Essential longevity testsMe on Kayla's podcast: https://www.youtube.com/watch?v=rxhTlWwKKv0Kayla Barnes-Lentz Channel: https://www.youtube.com/@UCvCqI5fz4Wz-3qnInO02dqA

24 Apr 1h 7min

Timestamps:00:00 Intro00:37 Thoughts on Bryan Johnson stopping rapamycin06:59 Are more antioxidants always better09:57 Supplements versus lifestyle for longevity12:43 Life extension compounds other than rapamycin17:00 Matt’s controversial takes on supplements and lifestyle28:30 My book promo28:55 Matt’s thoughts on peptides for longevity34:35 Thymus rejuvenation protocol44:55 NAD IVs and Therapeutic Plasma Exchange45:02 Does low IGF-1 support longevity53:13 Using AI in longevity research57:46 How much protein for longevity01:00:38 Why is grip strength linked to longevity01:02:25 Preserving female reproductive function01:06:52 Slowing aging in dogsMe on Matt's podcast: https://youtu.be/3Hm3a-SWPBIMatt Kaeberlein YouTube: https://www.youtube.com/@UCSna7385c3Xg_4Too92NKMw Order my new book: https://www.amazon.com/dp/B0CW1B2XM1

17 Apr 1h 11min

Order my new book: https://www.amazon.com/dp/B0CW1B2XM1Timestamps:00:00 Intro01:07 Julie’sreaction to the news articles about her04:12 How Juliegot interested in health11:52 My bookpromo12:14 Julie’s2025 diet routine20:47 Fastingmimicking diet26:02 Julie’sexercise routine28:42 Bonedensity and menopause33:22 Supplements40:22 What doesJulie’s family thinks about health46:32 Sleep53:22 BloodworkJulie Gibson Clark Instagram: https://www.instagram.com/juliegibsonclark/Julie Gibson Clark YouTube: https://www.youtube.com/@juliegibsonclark

11 Apr 59min

Get Bon Charge Infrared Sauna Blanket (Code SIIM): https://boncharge.com/siimlandTimestamps:00:00 Intro00:50 Why is the liver such an amazing organ04:05 Consequences of liver fat accumulation07:05 Can you reverse liver damage and liver fat09:50 Visceral fat vs liver fat11:20 Bon Charge sponsorship12:05 Key determinants of liver fat14:45 Do you need to lose weight to lose liver fat16:10 Diet for losing liver fat22:00 How to measure liver fat26:45 Alcohol30:20 Types of fats37:50 Supplements47:55 Which exercise is best for lowering liver fat51:20 Does cortisol promote liver fat accumulation53:45 How sleep affects where you lose fat57:00 Eating speed and underrated foodsAndy de Santis Instagram: https://www.instagram.com/andytherd/

4 Apr 59min

Join the Health Optimisation Summit (Code SIIM for discount): https://usa.healthoptimisation.com/?promo=SIIMTimestamps:00:00 Intro01:30 How to get sleep when your mind is racing06:45 Thoughts on agmantine sulfate08:25 Food sensitivities and autoimmunity14:20 Is NMN safe long-term18:20 Is CoQ10 worth it?24:30 Omega-3 supplements and biological age26:40 Optimal astaxanthin dosage29:20 How to increase free testosterone fast32:45 Magnesium supplements giving anxiety36:45 Choline supplements40:40 If you take D3 can you get K2 from foods44:05 Does high protein cause urea problems46:50 Hayfever remedies48:35 Are the benefits of collagen because of glycine53:10 Using AI for healthTim Biohacker Instagram: https://www.instagram.com/timbiohacker/

28 Mar 1h

Get Bon Charge red light therapy for 15% off: https://boncharge.com/pages/siimlandTimestamps:00:23 Dr Sandra’s 7 Tenets of Aging03:20 Rating system for supplements05:00 Astaxanthin07:50 NAD boosters11:15 Bon Charge Ad12:05 Glycine15:30 Curcumin18:50 Ginger and GLP122:25 Melatonin24:30 Carnosine30:15 AKG35:20 Taurine39:05 Disappointing supplements39:50 Resveratrol43:40 Multivitamin46:10 Dihydromyricetin 48:45 Antihistamines and other pharmaceuticals57:10 Essential supplement stackDr Sandra Kaufmann Instagram: https://www.instagram.com/kaufmannantiaging/

21 Mar 1h 2min

Order my new book: https://www.amazon.com/dp/B0CW1B2XM1Timestamps:00:16 Philosophy for bloodwork and longevity09:36 Most important bloodmarkers to measure14:20 Bloodmarkers for heart disease and metabolic disease21:20 Is low cholesterol bad31:00 Malnutrition and cachexia40:40 Biological age clocks43:55 Standardized protocol before taking bloodwork52:50 Heavy metals56:25 Bloodwork for unlimited budgetDr Michael Lustgarten YouTube channel: https://www.youtube.com/@conqueragingordietrying123/

14 Mar 1h 4min