One month dual antiplatelet therapy non inferior to standard regimens- MASTER DAPT TRIAL

One month dual antiplatelet therapy non inferior to standard regimens- MASTER DAPT TRIAL

Prolonged dual antiplatelet therapy is the treatment of choice for patients with acute coronary syndrome who have undergone percutaneous coronary intervention (PCI) with a drug-eluting stent. The rationale is anchored in the understanding that drug-eluting stents impair the vascular healing process because exposure of the metal in the stent serves as a nidus for stent thrombosis. But the ideal duration of this therapy is still a gray area for stable angina patients undergoing PCI. The appropriate duration of dual antiplatelet therapy in patients at high risk for bleeding after the implantation of a drug-eluting coronary stent remains unclear. Researchers have shown that 1 month of dual antiplatelet therapy (DAPT) is non-inferior to the continuation of therapy for at least 2 additional months with regard to the occurrence of net adverse clinical events and major adverse cardiac or cerebral events; along with the added advantage of lower incidence of major or clinically relevant nonmajor bleeding. The results of this multicenter, randomized, open-label, noninferiority trial with sequential superiority testing were published in the latest issue of NEJM last week.

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