#482 Why Scientists Believe Lithium May Be a Longevity Molecule
Jon Berner, MD PhD is a board certified Psychiatrist from Seattle with 27 years of experience. He's also published several scientific papers.Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:20 Why Dr Berner became interested in lithium04:50 Lithium’s benefits in Alzheimer’s and dementia10:50 Lithium’s effects on mTOR and autophagy12:50 Bon Charge sponsorship13:40 Clinical evidence for lithium in dementia18:20 What’s the optimal dose for lithium26:25 Lithium for bipolar and hyperactive brains29:25 Lithium as potential treatment in neurodegeneration31:55 Lithium’s effects on kidneys34:20 Personal experience with taking lithium40:40 Is it safe to take lithium prophalactically over the counter47:55 Rapamycin synergy with lithium51:45 AI and human developmentDr Berner's practice: https://www.woodinvillepsychiatric.com/100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi
5 Des 1h 1min
#481 The Anti-Aging Pill Chinese Scientists Are Developing - Aiming for 120+ Lifespans - Yip Tszho
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandYip (Zico) Tszho is the Chief Executive of Lonvi Biosciences, a longevity-drug start-up, in Shenzhen, China. They're developing pharmaceuticals for extending human lifespan. We discuss their first senolytic called PCC1. Timestamps:00:00 Intro00:15 Articles about a pill making people live to 15002:50 What is PCC1 and how is it made07:10 How much can targeting senescence extend lifespan12:25 Bon Charge sponsorship13:15 Dose of PCC1 for senolytic and senomorphic effects18:30 PCC1 extending lifespan in mice by 9.4%23:20 Absorption rate of PCC1 and other senolytics27:10 Senolytics for young vs old age31:10 Human study on PCC134:40 What’s the optimal dose for senolytics38:05 Biomarkers of cell senescence40:10 Senolytic benefits on skin and retina46:35 What’s going on in Chinese longevity science52:10 Future direction of PCC1PCC1 studies: https://lonvibio.com/pages/science
29 Nov 59min
#480 The Science of Saunas: How Heat Boosts Fitness & Longevity - Brady Holmer MSc
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandBrady Holmer is a science writer and researcher with a Master's degree in Human Performance from the University of FloridaTimestamps:00:00 Intro00:40 Why heat acclimation has performance benefits08:10 How to train heat acclimation12:40 Bon Charge sponsorship13:30 Benefits of the sauna for fitness18:25 Saunas and injury recovery22:30 Cold exposure and exercise performance26:45 Cooling down during and before exercise31:40 How often to train heat acclimation and sauna37:05 Sauna and HRV38:10 How long to stay in the sauna41:15 Electrolytes and dehydration acclimation46:25 Differences between men and women in heat acclimation47:00 Does heat acclimation have longevity benefits49:05 Does cold exposure have longevity benefits54:30 Which research should be done more on heat acclimationFirst podcast with Brady about VO2 max: https://youtu.be/xLDaFhN6h8IBrady Holmer Twitter: https://x.com/B_HolmerBrady Holmer website: https://www.bradyholmer.com/Start rewinding your biological clock: https://www.siimland.co/course
21 Nov 59min
#479 Longevity Testing 101: What Really Matters (with Siim Land and Dr. Joy Kong)
Join our upcoming retreat in January 2026: https://www.siimland.co/retreat Timestamps:Introduction (00:00)Discussion on longevity clinics and testing (01:52)Essential health tests and biomarkers (05:45)Improving VO2 Max and cardiovascular health (11:28)Blood tests and metabolic health (16:42)Hormone tests and longevity (21:35)Microbiome tests and toxicity (26:55)Microplastics and environmental toxicity (32:14)Food sensitivity testing (39:01)NAD testing and energy metabolism (41:50)Comprehensive health retreat (49:29)Dr. Joy Kong Youtube channel: https://www.siimland.co/retreat
14 Nov 1h 4min
#478 Mitochondria Scientist: The Only Proven Way to Extend Human Lifespan - Dr Mark Tarnopolsky
Dr. Mark Tarnopolsky is a Professor and Division Head of Neuromuscular and Neurometabolic Disorders in the Department of Pediatrics at McMaster University. He completed a PhD in Cell Biology and Metabolism in 2001.Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:25 What are mitochondria03:55 Mitochondria in aging and longevity06:00 Oxidative stress, inflammation, and longevity09:30 Antioxidants and benefits of exercise12:40 Bon Charge sponsorship13:30 Who should take antioxidants21:30 Mark’s antioxidant cocktail study24:30 Why is exercise the best thing for your mitochondria30:35 How endurance training shapes the mitochondria35:10 High intensity interval training36:50 Role of mitochondria in muscle loss42:00 Nutrition for mitochondrial health46:50 Supplements for mitochondrial health53:35 Stimulating mitophagy Dr Mark Tarnopolsky research page: https://scholar.google.com/citations?user=4jhi_KkAAAAJ&hl=en
8 Nov 59min
#477 The Science of Longevity Genes: What We’ve Learned from Centenarians - Dr Tyler Panzner
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:48 The genetics of a 117-year-old woman08:16 Resilience, immunity and longevity14:33 Muscle building genetics19:33 FOXO3 and stress resilience24:53 FOXO3 gene editing32:08 Can telomere lengthening be harmful to some individuals38:58 IGF-1 and growth hormone and longevity50:08 Genetically short sleepers54:38 What you should know about your longevity genesFirst podcast with Tyler about genetics and supplements: https://youtu.be/9GLbTEYewUsTyler Panzner channel: https://www.youtube.com/@drtylerpanzner
31 Okt 1h
#476 Siim Land on Human Immortality, Gene Editing, Biomarkers - The Beyond Tomorrow Podcast
Timestamps0:00 – Introduction4:12 – Humans adapt, and that changes the rules9:58 – Diet diversity, sensitivities, and n of 116:51 – Assess first: biomarkers that predict disease risk18:27 – Fixing sleep, movement, diet, environment22:47 – Caution on rapamycin, metformin, methylene blue25:54 – FOXO3 stem-cell study and what it means37:15 – Mindset and willpower as real enhancers41:44 – TMG, astaxanthin, melatonin, creatine47:09 – VO2 max priorities and performance trade-offs48:51 – Balancing fitness with joy and purpose53:18 – Biomarkers mediate risk more than labels1:01:00 – 2030–2040: what is realistic1:04:02 – Immortality probabilities and living well nowJulian Issa video podcast: https://youtu.be/vV8yMVGLG6Y?si=XiLxOx0bSSM-xT-v
24 Okt 1h 6min
#475 Q&A: Biggest things that contribute to my health, does caffeine age the brain, can you make up for lost sleep and more
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Does exercise increase inflammation03:03 Melatonin megadosing research04:23 NOVOS vs Blueprint VS DoNotAge07:44 Hidden things that contribute to my health12:14 Bon Charge sponsorship13:05 How to improve night shift work15:40 Supplements to take before the sauna17:15 Does caffeine age the brain19:34 Can you make up for lost sleep20:40 Thoughts on Urolithin A23:14 Doing too much for longevity27:59 How to stop waking up at 3AM30:57 How much sodium do I consume33:20 Do sleep supplements blunt natural sleep37:07 Inflammation in longevity41:23 Importance of good relationship with food
18 Okt 47min
