Is Your Testosterone Actually Low? Why Higher Testosterone Doesn't Do What You Think | Signal Ep 2
Out of 32 symptoms commonly attributed to low testosterone, only 3 actually correlate with it. All three are sexual. The other 29 — fatigue, brain fog, low mood, weight you can't lose, feeling not qui...
28 Apr 1h 1min
Direct Line April 2026: Stopping Ozempic and Lifting With Osteopenia
Stop a GLP-1 and about two thirds of the weight loss comes back within a year. Three randomized withdrawal trials (SURMOUNT-4, STEP 1 extension, STEP 4) and a new BMJ 2026 systematic review of 37 RCTs...
21 Apr 38min
Is the Testosterone Crisis Real? The Numbers Behind the Headlines | Signal Ep 1
A quarter of men start testosterone without a single lab test. Most boosters don't work. And the "testosterone crisis" headline is half testing artifact, half waistline. Two physicians walk through wh...
14 Apr 40min
Medical Mystery: The Man Who Got Weaker When He Started Training
A 43-year-old man starts exercising and ends up in the ER with a CK over 100x the upper limit of normal. His doctor says it’s from training. We don’t think so. In this episode, Dr. Jordan Feigenbaum a...
7 Apr 1h 15min
Overtraining Syndrome: Causes, Diagnosis, and What's Actually Going On
In 2022, researchers conducted the most rigorous systematic review ever performed on overtraining syndrome — looking specifically for controlled studies that documented a human transitioning from a he...
31 Mar 1h 36min
Episode #391: VO2 Max vs. Cardiorespiratory Fitness, GLP-1 Costs, and the 10,000-Step Myth | Direct Line March 2026 (Free)
In this free preview of the March 2026 Direct Line AMA. Drs. Feigenbaum and Baraki cover: VO2 max versus cardiorespiratory fitness for longevity (are Peter Attia’s targets evidence-based? — with Goodh...
24 Mar 30min
Episode #390: Why Your Waist Matters More Than Your Weight — The Science of Visceral Fat
You can have a completely normal BMI and be on your way to cardiovascular disease, type 2 diabetes, and metabolic syndrome without triggering a single alert on a standard health screening. The fat tha...
17 Mar 44min
Episode #389: Your Liver Enzymes Are Elevated — But It Might Not Be Your Liver
A fit, healthy 39-year-old was nearly sent for a liver biopsy. The cause? Was it that he went to the gym before every blood draw or because his supplement was throwing his labs off?. Dr. Jordan Feigen...
9 Mar 1h 1min
