Oprah's Most Memorable Guests

Original Airdate: April 21, 2009

Over the years, Oprah has interviewed close to 28,000 people from all walks of life. Let’s take a look back on the interviews we'll never forget. We’ll revisit the Mississippi man who shed over 300 pounds, the ex-husband of Susan Smith, the women who drowned her two children and the Boylan family whose father transitioned from male to female. Plus, an update from evangelist Ted Haggard and his wife on the scandal that made headlines.

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