#433: Sam Harris on Psychedelics, How to Cope During a Pandemic, Taming Anxiety, and More

Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.This episode is brought to you by: Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine: https://livemomentous.com/tim (code TIM for up to 35% off)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs)Timestamps:[00:00:00] Start.[00:14:43] Why I'm interested in ketogenic strategies for neurodegenerative prevention.[00:16:18] Mary and Steve Newport's ketone-linked temporary cognitive improvements.[00:18:18] A mechanisms overview for Alzheimer's/dementia.[00:21:25] The immune system as longevity's "fifth horseman" — and why metabolic control is key.[00:22:04] How to measure ketones and GKI.[00:23:00] Fasting vs. ketogenic diet.[00:24:18] There's nothing fishy about sardine fasting.[00:28:32] My hiatal hernia discovery and increased cancer risk concerns.[00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular risk.[00:31:57] Glucose tolerance testing revelations and CGM importance.[00:31:57] Upgrading the metabolic machinery through keto without getting bored.[00:42:07] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.[00:43:42] Dom's day-to-day diet regimen.[00:45:56] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.[00:51:30] Supplementing for sleep disruption while fasting.[00:55:41] Why Dom doesn't have misgivings about melatonin.[00:59:15] Shingles prevention through fasting protocols.[01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.[01:03:54] Dom at 50-something: Current meal timing and composition.[01:05:57] Blue zone observations: Greek and Sardinian longevity habits.[01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.[01:15:18] Ketone metabolic therapy for cancer.[01:18:15] The metabolic psychiatry revolution.[01:22:10] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.[01:28:27] Metformin vs. berberine.[01:31:43] The low-dose neuroprotective potential of GLP-1 drugs.[01:34:58] NAD research: MIB-626 and stabilized forms for mitochondrial health.[01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.[01:42:05] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.[01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.*Show notes for this episode: https://tim.blog/2025/07/24/dr-rhonda-patrick/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Sep 1h 54min

Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes. This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 4.00% APY on your short-term cash until you’re ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.Timestamps:00:00 Tim’s intro: why he dismissed vagus-nerve hype06:34 What the vagus nerve actually is, plus common myths11:31 Breaking news: FDA approval for SetPoint’s RA implant + Kelly Owens’s turnaround21:11 Inflammation 101: when healing turns harmful31:37 Bioelectronic medicine: from lab insight to real devices55:26 TNF, IL-1, and IL-6: immune drivers and what VNS modulates56:06 Exercise & recovery: vagal signals, IL-6, and adaptation56:30 Cold exposure & breathwork: sympathetic spike, parasympathetic payoff59:04 Chronic inflammation today: prevalence, diagnostics, and uncertainty59:53 Autoimmunity: genes, environment, infections01:01:08 Stress hormones, personality traits, and metabolic fallout01:05:41 VNS tech landscape: implants, focused ultrasound, and what’s just TENS01:11:14 Ear maps, revisited: the real science behind auricular stimulation01:27:52 Ulf Andersson: auricular TENS, famotidine, and a depression turnaround01:36:48 Depression & inflammation: where VNS helps (and where it doesn’t)01:41:38 Body-brain loop: how inflammation signals ride the vagus nerve01:42:56 Why VNS can lift mood: a working theory01:43:22 Ulf’s setup: electrode placement and twice-daily routine01:44:37 Acupuncture, fertility, and plausible vagal links01:47:23 Chronic pain through an inflammation lens01:48:34 Neural “engrams”: how the brain can store inflammatory memories02:02:35 Cervical TENS vs. true VNS: mechanisms and open questions02:12:15 On stage with the Dalai Lama: blue energy and two vagus nerves02:16:55 Closing thoughts: self-care vs. medical devices, and what’s next*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Aug 2h 23min

Dr. Jeffrey Goldberg is Professor and Chair of Ophthalmology and Director of the Byers Eye Institute at Stanford University, a leading scientist in the development and degeneration of the visual system from eye to brain, and a practicing ophthalmologist and surgeon.This episode is brought to you by: Gamma AI design partner for effortless presentations, websites, social media posts, and more: https://gamma.app (Use code TIM at checkout for 30% off any plan.)Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off on all mattress orders.)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Timestamps:[00:00:00] Start.[00:05:30] How do you solve a problem like presbyopia?[00:08:34] The athletic benefits of training supranormal (better than 20/20) vision.[00:11:49] Indigenous eye drops and FDA-approved pilocarpine for presbyopia.[00:14:05] Understanding basic eye anatomy.[00:17:27] Exploring AREDS 2, CoQ10, ginkgo, vitamin B3, and other supplements for vision.[00:23:00] Visual training devices and psychedelic-prompted brain plasticity.[00:25:12] Thoughts on visual training effectiveness and motor action requirements.[00:28:29] Concussion rehabilitation and visual perception exercises.[00:32:36] Red light and violet light therapy for myopia and mitochondrial health.[00:36:07] Vision loss correlation with cognitive decline and depression.[00:39:36] Presbyopia progression and psychological dependence on readers.[00:41:15] Cognito Therapeutics headset for Alzheimer's treatment.[00:46:46] Glaucoma basics: neurodegenerative disease and risk factors.[00:48:53] Eye pressure variability and diurnal cycles.[00:50:02] Cannabis effects on eye pressure and compound isolation.[00:51:47] Stem cell research for vision restoration.[00:53:09] Anti-inflammatory effects and immune system role in eye diseases.[00:55:15] Gut microbiome connection to glaucoma in animal models.[00:58:43] Metabolic syndrome and GLP-1 receptor agonists.[01:00:50] Microbiome sharing and future therapeutic possibilities.[01:03:31] Dry eye treatment: preservative-free tears and serum drops.[01:08:43] Vision screening recommendations and UV protection.[01:11:22] Full-spectrum light benefits vs. UV exposure.[01:13:27] Paradigm shifts: irreversible vision loss becoming reversible.[01:17:18] Convergence of neuroscience advances and biotech investment.[01:21:58] Miraculous mitochondria: health, transplants, and three-parent babies.[01:26:24] My family history concerns and metabolic health screening.[01:29:26] Exercise's biggest gain: going from none to some.[01:33:03] Clinical trial participation resources and parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Aug 1h 44min

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)! We cover Kevin's sobriety journey and marking 100 days without alcohol, my results with the ketogenic diet and intermittent fasting, GLP-1 agonists, home security, the future of Venture Capital, AI, authenticating yourself online in a world of deepfakes and anonymity, the cultural shift toward human-to-human connection, Roblox, and more. Enjoy!This episode is brought to you by:Momentous high-quality creatine for cognitive and muscular support: https://livemomentous.com/Tim (Code TIM for up to 35% off.)David Protein Bars with 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/Tim (Buy 4 cartons, get the 5th free.)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Timestamps:[00:00:00] Start.[00:06:54] Kevin celebrates 100 days sober! Why and how?[00:15:16] Nanoblocks: Kevin's new Japanese micro-building hobby.[00:18:16] The Slow TV movement and Craig Mod's ambient recordings.[00:20:58] Craving analog experiences and wilderness trekking.[00:22:24] Writing with background movies.[00:23:42] High hopes for The Naked Gun reboot.[00:24:35] Kevin's improved communication since quitting alcohol.[00:26:28] My health interventions for cognitive protection.[00:29:00] How ketogenic diet and 16/8 intermittent fasting led to my best lab results in 10+ years.[00:33:35] Weight control regimens we don't recommend.[00:39:51] Exogenous ketones: Qitone vs. premium options.[00:50:32] How glucose tolerance tests work.[00:51:58] Microdosing GLP-1 (tirzepatide) for glucose control.[00:54:12] DORA sleep medications and neuroprotective effects.[00:56:55] Belsomra trial and cost considerations.[00:57:52] Sauna temperature optimization based on Rhonda Patrick's research.[01:00:28] There are no biological free lunches.[01:03:27] The time Kevin found a homeless person in his closet.[01:06:11] Modern home security and privacy measures.[01:19:42] Pondering how we survived childhood.[01:24:23] AI-driven venture capital landscape changes.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Aug 2h 7min

This is a very special episode for me. My brand-new card game, COYOTE, created in collaboration with Elan Lee and Exploding Kittens, is here. It is available in ~8,000 locations worldwide, including Walmart, Target, Amazon, and many others. Learn more: https://coyotegame.com.This episode is brought to you by: Gamma AI design partner for effortless presentations, websites, social media posts, and more: https://gamma.app (Use code TIM at checkout for 30% off any plan.) Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 4.00% APY on your short-term cash until you’re ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.Timestamps:[00:00:00] Start.[00:05:21] Coyote: a game 47 years in the making.[00:08:41] Who is Elan Lee?[00:09:37] How our motivations behind game creation intersect.[00:12:41] The nutshell view of pitching a game to a retailer.[00:14:40] Salesmanship is a learnable skill, but Elan’s a natural.[00:15:53] Why I’ve always wanted to make my own game and how development began in earnest.[00:26:00] First contact with Elan and our fast-forged, fun-focused friendship.[00:32:28] The Hanabi and Rock, Paper, Scissors-inspired Toronto trip breakthrough.[00:39:40] Early prototyping and testing.[00:45:34] The Zero Effect.[00:47:37] Recommended game design rationales, resources, and reading.[00:53:00] The beginner’s mind approach to writing effective game instructions.[00:56:26] A simple fact: less complication = more fun.[00:57:49] Cooperative vs. competitive play.[00:58:24] Leveling the playing field with attack cards and sabotage mechanics.[01:01:34] Tricking people into cognitively bettering themselves by gaming.[01:08:04] Finding the sweet spot.[01:10:44] It takes a lot of work to make a game effortlessly fun.[01:13:40] How many games does Exploding Kittens publish per year?[01:14:36] Exploding Kittens’ number-one seller was designed by Elan’s four-year-old daughter.[01:18:30] Prototypes and pitching.[01:22:26] Improving on the industry’s fundamentally flawed testing procedure.[01:24:58] Analyzing passing/failure with play testers’ video and feedback.[01:28:41] Risks of internal testing.[01:31:47] Coyote’s first positive signs from the wild.[01:34:22] Online vs. physical store sales and tweaking variables to gauge market interest.[01:41:22] What a successful line review looks like.[01:43:51] Line review hoops through which lesser-proven companies have to hop.[01:48:04] Elan’s field-tested line review meeting strategies.[01:54:15] The importance of finding proper agent representation.[01:59:35] In modern marketing, social media (especially short-form video) is king.[02:04:48] The best and worst ways for an aspiring designer to sell a game.[02:13:05] Crowdfunding pros and cons, and Kickstarter alternatives.[02:19:57] Dealing with deal terms.[02:23:56] The Exploding Kittens attitude toward rare partnerships.[02:25:45] The types of games that capture Elan’s attention.[02:27:40] Common game design mistakes.[02:29:49] How we tried to avoid these mistakes when packaging Coyote.[02:33:55] Self-publishing vs. conventional publishing.[02:38:40] Business considerations and risks.[02:44:59] Parting thoughts and a tantalizing offer.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Aug 3h

Elizabeth Gilbert is the #1 New York Times bestselling author of Big Magic and Eat, Pray, Love as well as several other international bestsellers. Her latest novel, City of Girls, was named an instant New York Times bestseller. Go to ElizabethGilbert.Substack.com to subscribe to “Letters From Love with Elizabeth Gilbert,” her newsletter, which has more than 120,000 subscribers.This episode was originally published in September 2024. Show notes and links: https://tim.blog/2024/09/26/elizabeth-gilbert-2/ Sponsors:Vanta trusted compliance and security platform: https://vanta.com/tim ($1000 off)Our Place's Titanium Always Pan® Pro using nonstick technology that’s coating-free and made without PFAS, otherwise known as “Forever Chemicals”: https://fromourplace.com/tim (Shop their sale now!) Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)Timestamps:[00:00:00] Who is Elizabeth Gilbert?[00:05:42] No cherished outcomes. [00:10:55] Self-compassionate ownership of responsibility. [00:15:52] The daily practice of writing letters from love. [00:22:22] Two-way prayer vs. one-way prayer. [00:30:57] The male approach to this practice. [00:34:27] How do you feel toward yourself vs. about yourself? [00:36:53] Understanding self-hatred to foster self-friendliness. [00:43:20] Setting boundaries and dealing with those who refuse to honor them. [00:50:15] Why (and how) Elizabeth avoids big family holiday gatherings. [00:52:15] Comfort in solitude. [00:53:38] Much abuzz about Elizabeth’s new ‘do. [00:57:52] Boundaries, priorities, and mysticism: a relaxed woman as a radical concept. [01:04:02] What mysticism brings to Elizabeth’s reality. [01:07:26] A better question to ask than “What do I want?” [01:09:32] Elizabeth’s hard-ass approach to project commitment. [01:16:40] Creativity guidance from Elizabeth’s higher power. [01:21:08] How *The Morning Pages* influenced *Eat, Pray, Love*. [01:24:27] More productive questions to ask than “Why?” [01:26:16] The pointlessness of purpose anxiety. [01:30:59] Balancing presence with other aspects of a well-lived life. [01:36:17] Comfort with mortality. [01:40:21] What motivates Elizabeth’s *Letters from Love* newsletter? [01:41:29] What can potential readers expect from this newsletter? [01:46:33] “Is the universe friendly?” — Frederic W. H. Myers [01:49:29] Parting thoughts. *Show notes for this episode: https://tim.blog/2024/09/26/elizabeth-gilbert-2/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Juli 1h 56min

Rhonda Patrick, Ph.D. (@foundmyfitness) is a biomedical scientist and the founder of FoundMyFitness, a platform dedicated to delivering rigorous, evidence-based insights on improving healthspan and mitigating age-related diseases.Sponsors:Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine and other supplements: https://livemomentous.com/tim (code TIM for up to 35% off)David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim (Buy 4 cartons, get the 5th free.)Monarch Money track, budget, plan, and do more with your money: MonarchMoney.com/Tim (50% off your first year at monarchmoney.com with code TIM)Timestamps:[00:00:00] Start.[00:04:54] Dealing with aging parents and other topics on the table.[00:10:43] How a common multivitamin helps reverse cognitive and memory aging.[00:12:04] The importance of supplementation — especially as we age.[00:13:10] Effectively supplementing with omega-3 fish oil to counter APOE4 and Alzheimer's risks.[00:16:50] The CoQ10 and omega-3 protocol that has helped Rhonda's father manage Parkinson's symptoms for nearly a decade.[00:19:28] Sulforaphane: a potent NRF2 activator with an unexpected benefit for Rhonda's mother's tremors.[00:25:34] How Rhonda convinced her mom to start CrossFit and the power of community-based, senior-focused fitness.[00:26:52] The earlier the intervention, the better the outcomes.[00:32:25] Intermittent fasting vs. extended fasting and my own results.[00:44:31] Does fasting destroy muscle mass? Debunking the catabolism fear and understanding the crucial role of the re-feeding phase.[00:57:24] "Dirty" fasting: what really happens to autophagy and metabolic benefits when you add a splash of cream or MCT oil to your coffee?[01:00:44] VO2 max: the one metric that may predict lifespan more accurately than anything else, and how we work to improve it.[01:12:07] How a two-year exercise program reversed heart aging by 20 years in previously sedentary, middle-aged adults.[01:16:18] Lactate isn't the enemy: how vigorous exercise creates a superfuel that protects and grows the brain.[01:20:30] The optimal sauna protocol (temperature and frequency) for slashing dementia risk by 66%.[01:29:17] If you're human, you'll find a use for curcumin.[01:30:43] Creatine for cognition: moving beyond the gym with a powerful, science-backed tool for focus and combating sleep deprivation.[01:42:41] Still vitamin D deficient despite taking supplements? Here's the critical cofactor you're probably missing.[01:53:52] Shocking sources of microplastics in our daily lives, including chewing gum and teabags.[02:04:10] The uncomfortable truth about "moderate" alcohol consumption, cancer risk, and why the "sick quitter" hypothesis makes most older studies unreliable.[02:17:03] The ups and downs of ketamine and psilocybin on cognition and longevity.[02:24:19] Parting thoughts and where to find more from Rhonda.*Show notes for this episode: https://tim.blog/2025/07/24/dr-rhonda-patrick/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Juli 2h 31min

In this special episode, my friend—and fan-favorite guest—Dr. Peter Attia takes the mic as guest host. Peter sits down with legendary trader John Arnold, widely considered the greatest energy trader of all time. Today, through his foundation Arnold Ventures, John applies the same rigorous thinking to some of America’s toughest social challenges—criminal justice reform, healthcare policy, and K–12 education, to name just a few. This interview originally aired on Peter’s excellent podcast The Drive. You can check it out at PeterAttiaMD.com, or subscribe to The Drive wherever you get your podcasts.This episode is brought to you by:Vanta trusted compliance and security platform: https://vanta.com/tim ($1000 off)Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 4.00% APY on your short-term cash until you’re ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.Timestamps:[00:00:00] Start.[00:05:37] Peter Attia's intro: who is John Arnold?[00:08:38] John's background, upbringing, and early entrepreneurial tendencies.[00:21:16] John's time and rise at Enron.[00:33:40] Characteristics that made John an exceptional natural gas trader and how they translate to his philanthropic work.[00:41:10] The collapse of Enron.[00:46:46] The success of John's hedge fund, and his early interest in philanthropy.[01:02:03] The infamous 2006 trade that brought down Amaranth Advisors.[01:08:28] John's analytical prowess and emphasis on fundamentals.[01:15:13] The decision to become a full-time philanthropist and the founding of Arnold Ventures.[01:25:03] Education — John's quest to fundamentally change K-12 education.[01:30:36] Strategic philanthropy — preventing problems by attacking root causes and creating structural change.[01:37:50] The criminal justice system — structural changes needed to address mass incarceration, policing practices, and recidivism.[01:55:07] Re-imagining prisons to reduce recidivism.[02:02:27] US health care policy — John's focus on drug prices, and the severe consequences of not making system changes.[02:20:00] Climate change — the bipartisan role of John's foundation.[02:23:52] Advice for young adults interested in philanthropy.[02:30:52] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Juli 2h 36min