How Different Anabolic Steroids Can Affect Your Immune System And Vulnerability To Viral Infections
More Plates More Dates17 Mars 2020

How Different Anabolic Steroids Can Affect Your Immune System And Vulnerability To Viral Infections

Both Testosterone and anabolic androgenic steroids (AAS) adversely influence the immune system, affecting leucocyte growth or activity, and antibody and cytokine production, particularly when used at supraphysiological doses, mimicking a condition of secondary immunodeficiency [R, R]. Secondary immunodeficiency, much more common than primary immunodeficiency (that is to say those caused by genetic defects affecting the cells of the immune system), is characterized by various factors that affect a normal immune system, including infectious, iatrogenic, metabolic and environmental factors. These immune deficiencies are manifested clinically with an increased frequency or unusual complications of common infections and occasionally with the onset of opportunistic pathogen infections. https://youtu.be/ceqSC6GYks4 Nandrolone And Anadrol Effects On The Immune System Nandrolone Decanoate and Anadrol directly induce the production of inflammatory cytokines Interleukin 1 Beta (IL-1β) and Tumor Necrosis Factor Alpha (TNF-α) in human peripheral blood leukocyte cultures [R]. Testosterone and DHEA had no direct cytokine inducing effect in the same model. Nandrolone Decanoate also inhibits interferon production in NDV-infected mouse L-929 and human WISH cells. Winstrol And Trenbolone Effects On The Immune System Winstrol and Trenbolone were found to be genotoxic and cytotoxic to human lymphocytes in a dose dependent manner [R]. Testosterone, Teslac, Anavar And Winstrol Effects On The Immune System To evaluate how anabolic steroids affect the immune system, five commercially available steroids with various types of structural differences were studied in a rodent model [R]. Animals were divided into five groups and treated with Testosterone (group 1), Testosterone Propionate (Group 2), the steroidal aromatase inhibitor Testolactone (Teslac) (Group 3), Anavar (Group 4), and Winstrol (Group 5). Significant immunosuppression was observed with all groups. However, by day 10, the Teslac, Anavar and Winstrol treated group showed immunostimulation and actually exceeded baseline immunity while the Testosterone treated groups maintained immunosuppressed. To truly test the effects of endogenous androgens on the immune system a second experiment was then performed. Ten animals maintained in a similar manner to the initial experiment were either treated intact or were castrated and then treated for 8 days, with Anavar (1.1 mg/kg/day), Testosterone (1.1 mg/kg/day) or Anavar combined with physiologic amounts of Testosterone (15 μg/day). Anavar was selected because it has the greatest anabolic activity of all Testosterone analogues as compared to Testosterone (androgenic/anabolic activity = 1:13). In the intact animals after 8 days of treatment with Anavar, serum Testosterone levels were measured by radioimmunoassay on tail vein blood. Levels were either undetectable or very low, reflecting what would be significant HPTA suppression. Immune function (DCH responses) measured at the same time revealed a 41% increase over baseline. The Testosterone treated group experienced a 36% suppression of immune function. Further treatment for 8 days with Anavar combined with physiologic amounts of Testosterone eliminated the immune system enhancement provided by Anavar monotherapy and returned the DCH responses to levels that were not significantly different from baseline. The results were different in the castrated animals. Castration, resulted in an increase in immune (DCH) responses. The mean observed change was 90% greater than intact (pre-castration) baseline. That means that castrated rats had a 90% improvement above and beyond rats that weren’t castrated. Eight day administration of Anavar to these animals had an immunodepressive effect returning the DCH response to baseline. Eight day treatment with Anavar combined with physiologic doses of Testosterone produced an even greater suppression, 45% change from baseline. These observations indicate that immune alterations do occur with anabolic steroids which are immunosuppressive when the steroid nucleus is intact and immunostimulatory with nuclear alterations. How Steroids Influence Immune Function The hypothesis to explain the immune system responses to steroids is as follows. Exogenous androgenic anabolic steroids produce two effects on the immune system: (A) a direct early effect on immune function which is suppressive and, (B) an indirect delayed stimulatory effect mediated through the negative feedback on the pituitary. (B) results in inhibition of gonadal Testosterone through diminished LH release. A decrease in the synthesis of Testosterone results in low serum Testosterone level and immune stimulation. Castration, by abolishing the modulation of Testosterone secretion eliminates the effect of (B) but leaves (A) intact. In summation, the more suppressive a steroid is the more it can indirectly enhance immune function, simply by suppressing the endogenous production of Testosterone and its metabolites. However, anabolic steroids will also be genotoxic and cytotoxic to human lymphocytes in a dose dependent manner. So, the only reason anabolic steroids can enhance immunity is by being more tissue selective than Testosterone and by shutting down the HPTA, not by inherently being protective. They too will be inherently immunosuppressive, just to a lesser degree based on their tissue selectivity and magnitude of impact on endogenous androgen production suppression. At the end of the day, the data all suggests that the lower your levels of steroids are in the body, the higher level your immune system will function at in parallel. Are You Increasing Your Risk Of Viral Infection When You Are On Cycle? In summary, the vast majority of studies suggest that steroid use decreases antibody formation, Natural Killer (NK) lymphocyte activity, T and B lymphocyte maturation and stimulation resulting in immunosuppression [R]. Supraphysiological doses of common anabolic steroids have been shown to directly influence the production of certain cytokines, altering immune function. The results from both animal and human studies suggest that supraphysiological doses of AAS can negatively impact the immune system. The takeaway from all of this is that with an easily spread virus infecting thousands of people throughout the world right now, it would be prudent to reduce your exogenous AAS use at least down to therapeutic levels to support immune function during this time where having increased vulnerability to viral infection is the most risky. Regardless if you are young and believe you are invincible based on the mortality rate statistics showing that the elderly are the most at risk of being symptomatic or ending up in critical condition, you may still be increasing your chances of becoming an infected carrier who then transmits the virus to the elderly (including your parents or grandparents) as a result of self-induced immunosuppression. Learn more about your ad choices. Visit megaphone.fm/adchoices

Avsnitt(1360)

Used Tren At 19 And Became An Angry Cheating Psycho

Used Tren At 19 And Became An Angry Cheating Psycho

📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Rigorous Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 👕 Fitness & Lifestyle Clothing: https://bit.ly/4dmGKqW | code "MPMD" for 15% off ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ X: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

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The Rock Has Officially Responded To Steroid Allegations

📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 👕 Fitness & Lifestyle Clothing: https://bit.ly/4dmGKqW | code "MPMD" for 15% off ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ X: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

9 Sep 202540min

The Return Of The King! [Gorilla Mind RUSH]

The Return Of The King! [Gorilla Mind RUSH]

🦍 Dialed in a bottle - https://gorillamind.com/products/gorilla-mind-rush ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 👕 Fitness & Lifestyle Clothing: https://bit.ly/4dmGKqW | code "MPMD" for 15% off ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ X: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

5 Aug 202556min

I Drug Tested Andrew Tate - Natty Or Not?

I Drug Tested Andrew Tate - Natty Or Not?

🧪 Rigorous Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 👕 Fitness & Lifestyle Clothing: https://bit.ly/4dmGKqW | code "MPMD" for 15% off ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ X: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

14 Maj 20252h 16min

This Should Be IMPOSSIBLE - 365lb Man GREW 6 INCHES!? | Brian Sanchez

This Should Be IMPOSSIBLE - 365lb Man GREW 6 INCHES!? | Brian Sanchez

Brian Sanchez, a 365 lb genetic freak who was already 6 feet tall, underwent limb-lengthening surgery to increase his height to 6’6”. For the first time ever he reveals the raw, unfiltered reality of the procedure, the excruciating pain, the grueling recovery, and the mental warfare of reshaping his own body. This is the ultimate deep dive into one of the most extreme body transformations ever attempted. ———————————— 📌 Sponsors: ⚕️ Marek Health - Preventive Medicine, HRT, & Rigorous Bloodwork Analysis: https://bit.ly/373k791 🦍 Gorilla Mind - Pre-Workout, Nootropic, Performance & Health Supporting Formulations: https://gorillamind.com/derek 💡 Intelligent Shop - Hair Loss Prevention, Exclusive Men’s Fragrances & Skin Care: https://intelligent.shop/derek ———————————— Brian’s Social Media: Instagram: https://www.instagram.com/brianthesasquatch/ YouTube: https://www.youtube.com/@brianthesasquatch ———————————— 🕑 Timestamps: 0:00:00 - Intro 0:03:57 - Brian’s Before And After Stats 0:05:48 - Why Brian Got Surgery When He Was Already 6 Feet Tall 0:12:45 - The Reasons Why Most People Get Limb Lengthening Surgery 0:16:20 - The Jack Hanma Story Of Steroid Use And Extreme Limb Lengthening Surgery 0:19:40 - Brian’s First Surgery (Of Many) 0:22:07 - Teens Using Pharmacology To Biohack Getting Taller 0:23:01 - Sponsor: Rigorous Blood Work Analysis With Health And Performance Optimization (Marek Health) 0:28:47 - How Brian Discovered Limb Lengthening Surgery And Convinced Himself To Do It 0:36:14 - How Brian Found A Clinic 0:38:51 - How Is Limb Lengthening Surgery Performed? 0:44:12 - The Max Height You Can Gain Surgically 0:45:58 - Deformed ‘Ballerina Feet’ Claw Syndrome 0:47:47 - Losing Over 100 Pounds To Do The Surgery 0:55:02 - Brian’s Steroid Use 0:55:55 - Sponsor: 4 Staple Supplements I Use Daily And Wish I Had Known About Sooner To Help Maximize My Growth, Recovery, And Health (Gorilla Mind) 1:02:43 - The Price Of Limb Lengthening Surgery 1:11:20 - The Worst Christmas Of Brian’s Life 1:12:58 - The Differences Between Surgery In The US Vs. Turkey (Part 1) 1:17:12 - The History Of Limb Lengthening Surgery 1:20:15 - How Much Can You Trust The Marketing Material Online? 1:26:46 - The Story Of Mr. Broken Bonez 1:33:14 - Brian Maxed Out His Tibias Before Breaking His Femurs 1:34:18 - How Broken Bones Lengthen Mechanistically, And The Risks Of “Non-Union” 1:37:52 - Justifying Femur Surgery Based On Tibia Proportions 1:40:23 - How Long It Takes To Max Out Height From Each Bone 1:43:43 - The Major Complications That Led To Requiring 11 Surgeries 1:52:48 - The Horrific Negligence In The Turkish Hospital 1:58:25 - Sponsor: Hair Loss Prevention, Exclusive Men’s Fragrances & Skin Care (Intelligent Shop) 2:02:17 - How Many People Died Of The 50 Brian Knows Who Had Limb Lengthening Surgery 2:05:26 - The Most Common Complications 2:12:37 - The Differences Between Surgery In The US Vs. Turkey (Part 2) 2:15:24 - The Best Transformations From Limb Lengthening Surgery Brian Is Aware Of 2:24:44 - The Average Height Gain And Recovery Time 2:27:02 - Obstacles Most Don’t Consider Before Getting Limb Lengthening Surgery 2:35:49 - Asking Brian If He Regrets His Decision 2:44:31 - How Dubious Marketing Can Mislead People Into Getting Surgery (Part 1) 2:45:52 - Clinics Overbooking The Amount Of Patients They Can Handle 2:50:25 - Hormone And Diet Optimization For Bone Integrity And Healing 2:53:50 - Brian’s Unrelenting Infection Caused By Surgery 2:57:48 - Is It Possible To Regain 100% Athleticism After Limb Lengthening Surgery? 3:10:37 - The Amount Of Pain Brian Endured From Start To Finish 3:12:56 - Brian’s Leg Size Before And After Surgery 3:13:24 - Brian Showing How Well He Can Walk Now 3:13:44 - Who Is The Ideal Candidate For Limb Lengthening Surgery? 3:17:36 - How Dubious Marketing Can Mislead People Into Getting Surgery (Part 2) 3:19:45 - Brian’s Future Plans ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

17 Feb 20253h 22min

The Real Life Jack Hanma

The Real Life Jack Hanma

📌 From My Full 3+ Hour Conversation With Brian Going Live This Weekend ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Rigorous Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ Twitter: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

13 Feb 202512min

The Story Of Mr. Broken Bonez - 5′5″ To 6 Feet Tall

The Story Of Mr. Broken Bonez - 5′5″ To 6 Feet Tall

📌 From My Full 3+ Hour Conversation With Brian Going Live This Week. ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Rigorous Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ Twitter: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

10 Feb 20256min

Steroid Use In The Fitness Industry | ft. Will Tennyson

Steroid Use In The Fitness Industry | ft. Will Tennyson

Will's channel and corresponding video: https://youtu.be/cuE5VHQYZoo?si=AcAU9Qxtqs-l-BS- 🧪 Rigorous Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ Twitter: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

6 Feb 202519min

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