Podcast 777: Grass, Weed, and Ancient Rome

Podcast 777: Grass, Weed, and Ancient Rome

Contributor: Chris Holmes, MD

Educational Pearls:

  • Antiemetics were used in ancient Rome to help with sea-sickness and included toxic substances such as wine and wormwood and white hellborn
  • The first antihistamine used for nausea, dramamine, was introduced in 1947 for motion sickness
  • After this chlorpromazine, prochlorperazine, and promethazine came about in the 1950s and 1960s
  • Cannabis, colloquially referred to as weed, isolates like THC used in the 1970s to help with chemotherapy-induced
  • After this in the 1980s, ondansetron and metoclopramide were introduced for more severe chemotherapy-induced nausea
  • Lastly, NK-1 inhibitors were introduced to treat nausea

References

Sanger GJ, Andrews PLR. A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research. Front Pharmacol. 2018;9:913. Published 2018 Sep 4. doi:10.3389/fphar.2018.00913

Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD

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Podcast 999: Right vs Left Internal Jugular Access

Podcast 999: Right vs Left Internal Jugular Access

Contributor: Travis Barlock, MD Educational Pearls: What is an internal jugular catheter (IJ) and when do we use it? IJs are catheters that can be placed in either the left or the right internal jugu...

23 Mars 2min

Podcast 998: Delayed Intubation After an Overdose

Podcast 998: Delayed Intubation After an Overdose

Contributor: Aaron Lessen, MD Educational Pearls: How long do we need to watch patients with a presumed overdose who were treated with naloxone in the field? A 2025 study in the Annals of Emergency M...

16 Mars 3min

Podcast 997: D-Dimer

Podcast 997: D-Dimer

Contributor: Travis Barlock, MD Educational Pearls: D-dimer: fibrin degradation product used to evaluate for clot formation and breakdown Threshold: Elevated D-dimer indicates recent or ongoing int...

9 Mars 2min

Podcast 996: Melatonin

Podcast 996: Melatonin

Contributor: Taylor Lynch MD Educational Pearls: Melatonin is an endogenous hormone released primarily by the pineal gland Also released by extrapineal regions in the retina, the GI tract, and some ...

2 Mars 4min

Episode 995: UTI Diagnosis

Episode 995: UTI Diagnosis

Contributor: Travis Barlock, MD Educational Pearls:  Foul-smelling urine and cloudy urine are commonly misinterpreted as indicators of a UTI. However, these findings alone are not diagnostic. Criteri...

24 Feb 5min

Podcast 994: Biphasic Anaphylaxis

Podcast 994: Biphasic Anaphylaxis

Contributor: Aaron Lessen, MD Educational Pearls: What is anaphylaxis and what are its treatments?  Anaphylaxis is a broad term for potentially life threatening allergic reactions that can progress t...

16 Feb 3min

Podcast 993: Personalized Gene Editing Therapy

Podcast 993: Personalized Gene Editing Therapy

Contributor: Alec Coston, MD Educational Pearls: Disclaimer: this has nothing to do with the ER but is too cool to not talk about. Condition: Carbamoyl phosphate synthetase 1 (CPS1) deficiency Ra...

9 Feb 6min

Tox Talks 2025 Recap 2, Methemoglobinemia and Errors

Tox Talks 2025 Recap 2, Methemoglobinemia and Errors

Contributors: Travis Barlock MD, Ian Gillman PA, Jacob Altholz MD, Jeffrey Olson MS4 In this episode, EM attending Travis Barlock and medical student Jeffrey Olson listen in to the two remaining cases...

4 Feb 41min

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