This Brain Trick Feels Like Cheating (Do THIS) : 1402
Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain’s immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, metabolism, and brain health. A Fellow of the American College of Nutrition and member of the Editorial Board of the Journal of Alzheimer’s Disease, Dr. Perlmutter brings decades of clinical and research experience to this conversation on how inflammation and mitochondrial function shape the brain across the lifespan. Together, they explore how microglial cells shift their behavior based on metabolic conditions, and how those shifts influence neurodegeneration, emotional regulation, impulse control, and cognitive performance. The discussion covers real-world inputs that shape these systems, including sleep optimization, fasting, ketosis, glucose regulation, gut signaling, environmental toxins, and tools referenced in the episode such as red and infrared light, 40 Hz light and sound, hyperbaric oxygen, lithium, nicotine, supplements, nootropics, GLP-1 agonists, and dietary approaches like carnivore and ketosis. The conversation connects brain biology to lived experience, showing how metabolism influences behavior, decision making, and long-term human performance through a Smarter Not Harder lens. You’ll Learn: • How microglia shift between supportive and destructive states and why metabolism drives that change • How mitochondrial function inside immune cells influences inflammation and brain resilience • How inflammation affects the prefrontal cortex, impulse control, and reward-driven behavior • What the episode says about GLP-1 agonists and behavior changes like reduced cravings and gambling • How gut-derived signaling and short-chain fatty acid balance (butyrate vs propionate) relates to brain function • How tools like red and infrared light, hyperbaric oxygen, and 40 Hz light and sound connect to microglia • The lifestyle levers discussed in the episode: sleep optimization, fasting, ketosis, glucose control, and toxin reduction • The compounds mentioned, including lithium, nicotine, urolithin A, CoQ10, rosmarinic acid, and dihydromyricetin Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microglia brain health, brain immune system mitochondria, neuroinflammation podcast, mitochondrial dysfunction brain, david perlmutter podcast, dr david perlmutterneurologist, grain brain author podcast, alzheimers brain metabolism, parkinsons microglia, autism brain inflammation, gut brain immune signaling, short chain fatty acids brain, butyrate propionate brain, glp-1 brain behavior, glp-1 addiction research, red light therapy brain, infrared light mitochondria brain, 40 hz light sound brain, hyperbaric oxygen brain health, lithium microglia brain Resources: • Learn More About Dr. Perlmutter at: https://drperlmutter.com/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 1:45 - Autism Spectrum 4:38 - Alzheimer’s & Beta Amyloid 7:02 - Brain Immune Cells 8:06 - GLP-1 & Parkinson’s 10:44 - M1 vs M2 Microglia 13:08 - Pharmaceutical Microdosing 15:51 - Gene Therapy 19:09 - Mold & Toxins 21:58 - Environmental Pollution 26:05 - MPTP Discovery 29:07 - Healing Interventions 31:39 - Light & Sound Therapy 36:35 - Mitochondrial Function 44:57 - Inflammation & Prefrontal Cortex 48:00 - GLP-1 Global Impact 52:11 - Mitochondrial Community 56:05 - Consciousness & The Field 1:00:00 - Psychedelics 1:01:59 - Love & Judgment 1:06:35 - Death & Knowing 1:09:06 - Heart-Brain Connection 1:11:06 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
22 Jan 1h 13min
Inside the Mind of the Mad Scientist Rewriting Aging : 1401
Your body does not fail all at once. Aging starts when cells quietly shift into survival mode and never come back out. In this episode, you go inside the thinking of a true medical outlier to understand how stress, travel, toxins, and metabolic overload reprogram cells, shut down energy, and accelerate aging, and how restoring mitochondrial function can reverse that trajectory from the inside out. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Theodore Achacoso and Boomer Anderson, leaders in Health Optimization Medicine and Practice. Dr. Achacoso is a physician-scientist and the founding pioneer of Health Optimization Medicine, known for his work on cellular networks, metabolomics, and mitochondrial function. Boomer Anderson is the CEO of Smarter Not Harder and Troscriptions, where he focuses on translating complex biology into practical tools for human performance and longevity. Together, they unpack how cells respond to perceived threats through the Cell Danger Response, why mitochondria control energy, inflammation, and repair, and why chasing disease labels misses the real drivers of aging. The discussion covers methylene blue as an electron recycler, why LDL cholesterol plays a role in detoxification and immune signaling, how fasting and ketosis shift metabolism between repair and growth, and why sleep optimization, circadian rhythm, and light exposure matter even more when you travel. They also explore neuroplasticity, consciousness, nootropics, supplements, and why health optimization works best when you restore balance instead of forcing outcomes. You’ll Learn: • What the Cell Danger Response is and how it reshapes aging and performance • How mitochondria sense stress before symptoms appear • Why cellular energy controls resilience, sleep, and longevity • How methylene blue supports mitochondrial electron flow • Why fasting and ketosis shift metabolism between repair and growth • How travel, light, and circadian disruption affect aging • Why very low LDL can impair detoxification and immune signaling • Why real anti-aging starts at the cellular level, not with disease labels Thank you to our sponsors! AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. Screenfit | Get your at-home eye training program for 40% off using code DAVE at www.screenfit.com/dave. Puori | Use code DAVE at puori.com/DAVE to get 32% off your Puori Fish Oil when you start a subscription. You save more than $18. fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: cell danger response podcast, mitochondria aging, mitochondrial dysfunction aging, health optimization medicine, dr ted achacoso, boomer anderson, troscriptions, troscriptions methylene blue, methylene blue mitochondria, methylene blue biohacking, cellular aging podcast, anti aging mitochondria, metabolic stress aging, fasting ketosis metabolism, mitochondrial energy production, neuroplasticity mitochondria, sleep optimization aging, functional medicine mitochondria, smarter not harder biohacking, dave asprey mitochondria Resources: • Get A Discount On All Troscription Products with code ‘dave’ at: https://troscriptions.com/ • Learn More About Methylene Blue From My Full Masterclass Covering The Topic: https://daveasprey.com/mb/ • Discover More About The ‘Health Optimization Medicine and Practice’ From Our Guests: https://homehope.org/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:25 – Introduction & Guest Background 3:11 – Health Optimization Medicine Origins 4:26 – Root Causes of Health vs Disease 6:15 – Biohacking & Self-Experimentation 8:19 – Medicinal Plants & Nootropics 11:25 – Travel & Jet Lag Solutions 13:42 – Cell Danger Response 17:38 – Metabolites & Cellular Health 18:57 – LDL & Lipopolysaccharides 20:42 – Cellular Model & First Principles 22:55 – Consciousness & Mitochondria 25:46 – Nanotechnology Research 28:55 – Giving Back & Service 31:17 – Blue Cannatine Development 34:48 – Methylene Blue Products 36:22 – Metformin Discussion 38:00 – Dosing & Cordycepin 41:25 – Closing & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
20 Jan 42min
I Lost 100 Pounds Of Fat By Drinking Fat (Just Do This) : 1400
One freezing sip on a Tibetan mountain rewired his hunger, silenced cravings, and unlocked a kind of fat-burning “switch” no doctor ever mentioned. What happened next—Silicon Valley obsession, a global butter shortage, and a new theory of weight loss—might change how you see food forever.The only coffee I drink: Danger Coffee: https://dangercoffee.com/DAVE15Thank you to our sponsors! - GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air. - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.Resources: • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ Facebook: https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
18 Jan 22min
The Superbrain Drug Politicians Use To Outsmart Everyone : 1399
This drug has been misunderstood for decades, and that confusion is costing people focus, learning speed, and cognitive performance. In this episode, you’ll learn why nicotine itself is not the problem, why delivery method and dose change EVERYTHING, and how oral nicotine can be used strategically for biohacking brain optimization, neuroplasticity, and human performance in a healthy and safe way. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with David Renteln, Co Founder and CEO of LUCY Nicotine, a company pioneering science led alternatives for adult nicotine users who want better options. Before launching LUCY, David was also a co founder of Soylent, where he helped pioneer new approaches to functional nutrition and metabolism. Together, Dave and David break down how nicotine works in the brain through acetylcholine and dopamine, why speed of absorption determines addiction risk, and how nicotine affects learning, memory, motivation, and mood. The conversation also covers sleep optimization, mitochondrial signaling, tolerance, cycling strategies, and why modern regulation often slows innovation in functional medicine, anti aging science, and human performance.You’ll Learn: • Why nicotine itself is not the same as smoking or vaping • How delivery speed changes addiction risk and brain response • How nicotine supports learning, focus, and neuroplasticity • Why acetylcholine matters for memory and brain optimization • How to think about dosing, cycling, and tolerance safely • How nicotine stacks with caffeine, nootropics, and Danger Coffee • The relationship between nicotine, sleep architecture, and REM • Why harm reduction matters for longevity and mitochondrial health • How nicotine fits into a Smarter Not Harder biohacking strategy Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! -Lucy! Get a 20% discount by using code ‘Dave’ at www.lucy.co/daveDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: nicotine podcast, nicotine nootropic, oral nicotine benefits, nicotine brain optimization, nicotine acetylcholine dopamine, nicotine learning memory, nicotine addiction risk, nicotine pouches vs smoking, LUCY nicotine, david renteln lucy, david renteln nicotine, lucy nicotine pouches, harm reduction nicotine, nicotine biohacking, nicotine human performance, nicotine longevity, nicotine neuroplasticity, nicotine sleep optimization, nicotine tolerance cycling, caffeine nicotine stack, danger coffee nicotine, dave asprey nicotine, dave asprey lucy, nootropics nicotine, functional medicine nicotine Resources: • HeartMath | Go to https://www.heartmath.com/dave to save 15% off. • LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:10 – Origin Story 2:20 – Product Forms & Usage 3:52 – Effects & Mechanisms 9:21 – Dosing & Addiction 15:33 – Memory & Cognitive Benefits 18:57 – Personality & Stacking 21:41 – Quitting Smoking 24:39 – Government Regulation 32:00 – Addiction Philosophy 35:30 – Behavior Change & Routines 39:08 – Final Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
16 Jan 46min
Why 65% of People SUCK at Modern Relationships : 1398
Most people are struggling in modern relationships, and it is not because they are broken. It is because the systems around them are. In this episode, you’ll learn why roughly 65 percent of people operate from insecure attachment, why that quietly destroys energy, trust, and intimacy, and how secure attachment becomes a critical biohacking upgrade for human performance, longevity, and emotional resilience. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Adam Lane Smith, MA Psych, a leading global expert on Attachment Theory and the neurobiology of human bonding. Adam has spent over 16 years studying and working in psychology, helping individuals, couples, and families repair broken relationships, rebuild trust, and develop secure attachment. His work focuses on skill-based nervous system training rather than talk therapy alone, often creating change in months instead of years. He now runs a global coaching practice and is on a mission to bring secure attachment to one billion people worldwide. Together, Dave and Adam break down why modern dating, career pressure, and social isolation have produced a generation of adults who feel emotionally exhausted, disconnected, and stuck in survival mode. They explain how insecure attachment keeps people operating at low capacity, why bonding hormones like oxytocin and vasopressin regulate stress, sleep optimization, and emotional stability, and how broken attachment patterns sabotage metabolism, focus, and recovery. The conversation also covers AI companionship, dating apps, community collapse, and why no supplement, nootropic, fasting protocol, ketosis strategy, or carnivore diet can fully compensate for unsafe nervous systems. You’ll Learn: • Why 65 percent of people struggle with modern relationships • How insecure attachment caps energy, focus, and emotional resilience • Why secure attachment matters more as you age, not less • How bonding hormones regulate stress, sleep, and recovery • Why high performers still burn out without nervous system safety • How men and women experience attachment and regulation differently • Why AI and dating apps can worsen disconnection if used poorly • How community and shared purpose rebuild secure attachment • Why supplements and nootropics cannot replace real connection • Where to start if you want stronger relationships and higher capacity Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! -KillSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com and use code DAVE for 20% off. -Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. -MTE | Get 20% off MTE at https://www.getmte.com/dave using code DAVE. -Timeline | Go to https://www.timeline.com/dave and get 35% off a subscription with their New Year offer. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: adam lane smith, adam lane smith attachment theory, adam lane smith secure attachment, adam lane smith relationships, attachment theory podcast, secure vs insecure attachment, nervous system regulation relationships, oxytocin vasopressin bonding, modern dating psychology, relationship burnout, loneliness epidemic, attachment styles explained, biohacking relationships, dave asprey adam lane smith, dave asprey relationships, human performance psychology, midlife purpose and relationships, aging mindset, adam land smith dave asprey relationships Resources: • Get a discount on any of Adam’s courses with code “daveasprey10” at checkout! https://adamlanesmith.com/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Trailer 2:54 – The 30% Capacity Problem 4:19 – Historical Breakdown of Human Connection 9:31 – Building Pseudo-Families & Tribes 15:09 – The Modern Dating Problem 19:21 – Solutions for Women 26:49 – The Four Levels of Safety & Peace 33:04 – Solutions for Men 37:45 – Building Community & Finding Partners 45:26 – Marriage, Partnership & Legacy 52:23 – The Future & Social Culling 1:03:18 – Red Flags vs Green Flags in Dating 1:07:23 – Dating After 50 See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
15 Jan 1h 16min
The 12 Greatest Mood Boosters on Earth : 1397
Mood, motivation, and emotional resilience are not personality traits. They are biological systems. In this episode, you’ll get the 12 greatest mood boosters on Earth, not as a clickbait supplement list, but as the real biological levers that control dopamine sensitivity, hormones, neuroplasticity, and energy production.Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down in Dubai with friend of the show, Lucas Aoun, founder of Ergogenic Health and INB4, for a deep, experience driven conversation on dopamine, mood, and performance. Lucas is Australia’s leading biohacker, now based in Dubai, with a background in exercise science, naturopathy, and pharmacology. He is globally recognized for his work in dopamine regulation, testosterone optimization, and neurohormonal performance, and for rigorously testing protocols before recommending them. Together, Dave and Lucas explore how dopamine receptor upregulation changes motivation, mood, and resilience more effectively than stimulants alone. They break down compounds and systems discussed in the episode including solbutiamine, lithium orotate, sarcosine, inositol, uridine, testosterone, growth hormone, ketamine pathways, thyroid optimization, liver health, sleep quality, and desire regulation. The conversation also examines GLP-1 drugs, why they can blunt motivation, and how to think more strategically about long term mood and energy. This episode connects neuroscience, functional medicine, hormone biology, nootropics, and advanced biohacking ethics into a single framework for improving how you feel and function every day. Dave and Lucas also explain why experimentation requires guardrails, how to avoid tolerance and emotional flattening, and why upgrading baseline biology beats chasing quick fixes. You’ll Learn: • Why dopamine sensitivity matters more than dopamine levels • How mood, motivation, and desire are regulated biologically • Which compounds and systems came up as major mood levers • How testosterone and growth hormone influence emotional resilience • Why some longevity drugs may reduce motivation and drive • How sleep depth and mitochondrial function affect mood • The role of neuroplasticity in emotional regulation • Why strategic testing beats random supplementation • How to improve mood without addiction or burnout • Where to start if you want sustainable energy and motivation Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! -LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. -Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. -AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: dopamine sensitivity, dopamine receptors, mood boosters, motivation biology, dopamine supplements, natural mood boosters, biohacking dopamine, emotional resilience, anhedonia dopamine, focus and motivation, testosterone mood, growth hormone mood, ketamine alternatives, neuroplasticity mood, sleep and mood regulation, mitochondrial energy mood, GLP-1 dopamine effects, desire regulation, hormone optimization mood, dave asprey dopamine, lucas aoun biohacking, smarter not harder mood Resources: • Lucas's YouTube: https://www.youtube.com/c/boostyourbiology/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Introduction & Dopamine Discussion 2:55 – Dopamine Compounds 6:29 – Lithium & Emotional Regulation 9:37 – Pain, Suffering & Biohacking Ethics 13:56 – Trumpet Vine & Amphetamine Alternatives 17:55 – Nootropics & Experimentation 20:27 – Sarcosine & Fast-Acting Antidepressants 23:53 – Sugar Tolerance & Inositol 27:01 – Testosterone & Hormone Optimization 33:48 – Natural Testosterone Optimization 37:36 – Anabolic Agents & SARMs 39:38 – Growth Hormone & MK-677 40:38 – Cabergoline & Prolactin 49:03 – Thyroid & Reverse T3 51:18 – Liver Health & Tudca 54:53 – Ketamine & Psychedelics 1:02:01 – Experimental Compounds 1:07:05 – Advanced Peptides & Compounds 1:13:19 – GLP-1 Agonists & Dopamine 1:14:44 – Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
13 Jan 1h 16min
I Cracked The Code To Staying Lean In My 50s (Here's How) : 1396
Most people think fasting is just about skipping breakfast. But what if 72 hours without food could actually reverse aging?In this video, Dave Asprey breaks down what really happens when you fast for 3 days—and why short fasts don’t reach the deep repair zone your body is built for. Thank you to our sponsors! -HeartMath | Go to https://www.heartmath.com/dave to save 15% off.-Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface.Chapters0:00 - Why 16-hour fasts don’t reach real fat burning0:54 - The myth of aging and what doctors overlook1:48 - How modern life damages your mitochondria2:48 - How fasting restores your body’s repair mode3:39 - Understanding the phases of fasting4:58 - Why short fasts cut results short5:34 - Day 1 of fasting6:45 - Day 2 of fasting7:22 - Day 3 of fasting8:24 - Common fasting mistakes that harm your body9:35 - How to prepare before your fast10:31 - The right way to refeed afterward11:14 - Listening to your body’s signals and responsesResources: • Go To: www.qualialife.com/humanupgrade for an automatic extra 15% discount to try Qualia Creatine. • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ Facebook: https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
11 Jan 12min
Reversing The American Food Pyramid | Calley Means : 1395
Back in 2024 with Calley Means at South by Southwest, we sat down and talked about his mission to flip the old American food pyramid upside down for the greater good. Well guess what, the pressure is finally working! This rerun is the ultimate receipt that focus, repetition, and smart lobbying for human health can still move the needle! Host Dave Asprey sits down with Calley Means, entrepreneur, policy advocate, and co-author of Good Energy. Together, they break down how the U.S. healthcare system became a sick-care system, why ultra-processed food dominates public policy, and how individuals can reclaim autonomy over their biology. From CGMs and metabolic health to food subsidies, lobbying, and free speech, this episode challenges deeply held assumptions about medicine, nutrition, and personal responsibility.You’ll Learn: • Why chronic disease is the most profitable business model in modern history • How metabolic dysfunction drives obesity, diabetes, depression, and infertility • Why ultra-processed food sits at the root of America’s health collapse • How CGMs and metabolic data threaten entrenched healthcare incentives • What “food is medicine” really means and where it gets weaponized • How HSA and FSA dollars can legally support food, exercise, and prevention • Why fixing incentives matters more than blaming individuals • How reclaiming health autonomy is tied to free speech and human resilience Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Calley Means Good Energy, Calley Means interview, Good Energy metabolic health, metabolic dysfunction America, ultra processed food policy, food is medicine debate, healthcare incentives crisis, chronic disease economics, insulin resistance epidemic, CGM health data access, metabolic health lobbying, seed oils sugar inflammation, glyphosate food system, HSA food exercise eligibility, health autonomy biohacking, metabolic freedom podcast, american food pyramid, rfk food pyramid, 2026 food pyramid Thank you to our sponsors! Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. Resources: • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Introduction 2:11 – Mom’s Cancer Story 4:24 – Healthcare System Incentives 10:14 – TruMed and Food as Medicine 15:51 – FDA and IRS Pushback 17:25 – Political Solutions and RFK 19:49 – Childhood Obesity Crisis 21:49 – The Chronic Disease Industry 26:54 – State of Emergency Proposal 29:07 – Healthcare Industry Mindset 31:30 – COVID and Metabolic Health 32:28 – Taking Back Health Autonomy 34:16 – Medical System Collusion 35:56 – Research Corruption 37:21 – Pharma Bribes and Conflicts 40:17 – Ozempic and Civil Rights Groups 42:35 – Personal Mission and Mom’s Legacy 50:16 – Media Power and Free Speech 54:00 – Weaponizing Social Justice 55:16 – Systemic Poisoning of the Population 57:37 – Technology as a Health Solution 1:03:20 – Regenerative Farming and Robotics 1:06:34 – Controlling the Food Supply 1:10:18 – Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
9 Jan 1h 10min
