121. What is Naturalistic Research? with Dr Matthew X. Lowe

121. What is Naturalistic Research? with Dr Matthew X. Lowe

A conversation between Prof David Nutt and research scientist Dr Matthew X. Lowe.


Dr Matthew X. Lowe PhD is Director of Research for Realm of Caring and Executive Director for Unlimited Sciences, a not-for-profit, observational research organisation with a focus on cannabis and psychedelic use by underrepresented population groups and a toll-free info line providing evidence-based support for anyone using psychedelics.


In this episode, they discuss the vital role of observational and longitudinal research when it comes to the medicalisation of cannabis and psychedelics — and the importance for safetyof bringing real-world data into our collective knowledge base.


They start with the genesis of Realm of Caring and Unlimited Sciences. Both organisations were conceived following first-hand experience of the banned compounds they research being profoundly medically transformative — inspiring co-founder Heather Jackson to grow related research and make it freely available to all who stand to benefit from such education. The origin stories of the organisations are followed by Dr Lowe’s personal route to his current research role and the roots of his passion for pursuing psychedelic research questions.


Their focus then shifts to the present day with a comparison of roadblocks and red tape around researching cannabis and psychedelics in the UK and the US, noting the pioneering role that parents so often play in advocating for research into medicinal cannabis. Next comes a deeper exploration of specific properties of psychedelics that relate to their potential therapeutic applications, including their anti-addictive nature and positive habit-forming potential resulting from the neuroplastic window they potentiate — Unlimited Sciences has conducted the world’s largest naturalistic study on psilocybin use with further papers coming out on these implications.


For the remainder of the episode, Prof David Nutt and Dr Matthew Lowe go into specifics on several key projects from Realm of Caring and Unlimited Sciences, including:

- The Realm of Caring Observational Research Registry, being done in collaboration with Johns Hopkins Cannabis Science Laboratory. This ongoing research is an IRB-approved online survey study looking at the effects on a variety of health conditions, in people who do and do not use cannabis. It is open to everyone in the world with internet access.

- The Cannabis and Health Research Initiative (CHRI), another collaboration between Johns Hopkins and Realm of Caring, examining the patient-level impact of therapeutic cannabis use, through data collection and dissemination — aiming to aid clinical decision making and policymaking.


And finally, two ceremonial research projects looking at ayahuasca, foregrounding the role of community and context in ceremonial psychedelic experiences — both exemplifying Unlimited Sciences’ diversification of the evidence base on psychedelics by collecting real world data on underrepresented population groups:

- With subjects who were Arabic-speaking women, a study exploring the psychological benefits of ayahuasca for refugees — with DrugScience collaborator Dr Robin Carhart-Harris.

- And, currently in data analysis, with first results set to release in 2025, an IRB-approved study about ayahuasca use in the LGBTQIA+ community in collaboration with Costa Rica plant medicine retreat Jungle Gayborhood, with an emphasis on the importance of set and setting being truly safe spaces in the sense of meeting the specific needs of participants involved.


Find out more about Dr Matthew X. Lowe and Unlimited Sciences below!


Dr Matthew X. Lowe


Realm of Caring


Unlimited Sciences


The Psychedelic Info Line


Charlotte’s Web, Charlotte Figi and Realm of Caring


Realm of Caring’s research library


Long-term CBD study (Realm of Caring)


Observational Research Registry (Realm of Caring)


World’s largest naturalistic study on psilocybin use
(Unlimited Sciences)


Psychological benefits of ayahuasca for refugees
(Unlimited Sciences)


Jungle Gayborhood

The LGBTQIA+ study

★ Support this podcast ★

Avsnitt(142)

139. Poppers with Adam Zmith

139. Poppers with Adam Zmith

In this episode, we speak with Adam Zmith, podcast producer, writer, and author of Deep Sniff: A History of Poppers and Queer Futures. He describes his motivation behind writing the book, all before diving into the complex history of poppers. By speaking to the policing and regulation of poppers, Zmith explores broader struggles between the queer community and the government, in addition to the necessity for greater harm reduction for poppers. Despite these struggles, he underscores the ways in which queer culture has been shaped by poppers and how, in return, poppers have been shaped by queer culture. Links●      Adam Zmith●      Deep Sniff●      Poppers●      The Log Books●      Switchboard●      Sir Thomas Lauder Brunton●      UK Man Consumes Poppers Accidentally ★ Support this podcast ★

29 Okt 47min

138. Scottish Ambulance Service - Frontline Trauma with John, Joanne and Ryan

138. Scottish Ambulance Service - Frontline Trauma with John, Joanne and Ryan

Join us in this episode as Prof Nutt speaks to John, Joanne, and Ryan of the Scottish Ambulance Service in Glasgow. They explore their backgrounds in the Service and how their work exposed them to challenging situations that caused severe detriment to their mental health. After describing the failings of traditional mental health support for emergency workers, they tell their story of travelling to Peru for an ayahuasca retreat, an eye-opening and profoundly heartening experience. LinksScottish Ambulance ServicesAyahuascaHeroic Hearts Project UKThe ShipiboScottish Psychedelic Research Group ★ Support this podcast ★

16 Okt 53min

137. Cultural History of the Magic Mushroom with Dr Andy Letcher

137. Cultural History of the Magic Mushroom with Dr Andy Letcher

In this episode of the Drug Science podcast, we speak to Dr Andy Letcher, a religious scholar and author of the book Shroom: the Cultural History of the Magic Mushroom. He explores his complimentary background in science and the humanities, depicting how this combination structured his thinking. Noting the religious potential of psychedelic experiences, Letcher links the spiritual with the psychedelic, explaining what he sought to capture in his book and where it has gone since. Finally, he discusses how his interest in transdisciplinary perspectives on psychedelics has coalesced in the University of Exeter’s psychedelic postgraduate courses. PSYCH SYMPOSIUM 2025  LinksShroom: A Cultural History of the Magic MushroomPsychedelics: Mind, Medicine, and CulturePsilocybinSeeking the Magic Mushroom by R. Gordon WassonPsychedelia Britannia: Druids on Drugs ★ Support this podcast ★

2 Okt 43min

136. Parliamentary Office of Science and Technology with Jenny Chapman and Dr Stephen Naulls

136. Parliamentary Office of Science and Technology with Jenny Chapman and Dr Stephen Naulls

Tune into the latest episode of the Drug Science Podcast, where we talk to Jenny Chapman and Dr. Stephen Naulls, researchers at the Parliamentary Office of Science and Technology (POST) and authors of ‘Psychedelic-assisted therapy for mental health: Policy considerations, a briefing for Parliament’ on the state of psychedelic research. They explore the remit of POST in highlighting objective, emerging scientific research, and how psychedelics have come into their focus. With backgrounds in biology and medicine, both Jenny and Stephen stress the interwoven nature of science and policy. Through this intersection, they highlight the policy levers holding psychedelic researchers back and what Parliament and the greater public can take from the POST brief.   Links Parliamentary Office of Science and Technology POST report on Psychedelic-assisted therapy for mental health: Policy considerations, a briefing for Parliament Psychedelic drugs to treat eating disorders Psychedelic drugs to treat post-traumatic stress disorder (PTSD) Psychedelic-assisted therapy to treat anxiety disorders Psychedelic drugs to treat depression Psychedelic-assisted therapy in the treatment of addiction POST Board Fellowship opportunities  POST All Reports Knowledge Exchange Unit – KEU Horizon Scanning Ketamine ★ Support this podcast ★

17 Sep 47min

135. Ethnomycology with Darren Le Baron

135. Ethnomycology with Darren Le Baron

In this episode of the Drug Science Podcast, we speak with Darren Le Baron, an accomplished mycologist and educator. He discusses how his hardships from his upbringing in East London have informed his current work, where he uses horticulture to connect with children at risk of being drawn into crime. He transitions to explore his series Psychedelics in Africa, explaining some of the many links between psychedelics and African culture, both in ancient times and modernity. Throughout, he emphasises the importance of African perspectives and similar indigenous ones, challenging their absence in mainstream psychedelic discourse. LinksDarren Le BaronWho is Darren Le BaronDarren's Instagram   We Are Grow Mushrooms Psilocybin About Kilindi Iyi Psychedelics in Africa: The Untold Story Ibogaine  ★ Support this podcast ★

3 Sep 45min

134. Tribe with Bruce Parry

134. Tribe with Bruce Parry

Join us in this episode as we speak to Bruce Parry, the creator and star of the BBC series Tribe With Bruce Parry. He explains his sharp career change from a Royal Marine to an advocate for indigenous rights, where he’s developed a humble approach to learning from indigenous tribes, defined by listening and witnessing. He talks about his experiences of psychedelics in these contexts, namely ayahuasca, which have vastly shaped his outlook on life. Through this lens, he lends his opinions on topics like ayahuasca tourism and capitalist culture in the psychedelic space.Tribe with Bruce Parry Psilocybin Ayahuasca ★ Support this podcast ★

20 Aug 42min

133. Psychedelic Ethics with Dr Edward Jacobs and Sam Bloomfield

133. Psychedelic Ethics with Dr Edward Jacobs and Sam Bloomfield

In this episode of the Drug Science Podcast, we speak with Sam Bloomfield, founder of PsyEdu, and Dr. Eddie Jacobs, the first person to complete a doctorate in psychedelic ethics. Drawing on their backgrounds in education and ethics, they explore why these perspectives are essential to the evolving field of psychedelics. They also discuss the role of trials, clinics, and retreats within the broader psychedelic ecosystem, highlighting a major blind spot: the vast majority of psychedelic experiences occur outside of these settings. The conversation additionally examines how understandings of medicine often must adapt to the unique nature of psychedelics. Throughout, they underscore the importance of education in driving long-term policy change that ensures safer, more equitable, and more ethical psychedelic access.Psychedelic Training in the UKPsyEdu Beckley FoundationPsychedelic Ethics  Psilocybin MDMA MAPS Public Attitudes to Psilocybin-Assisted Therapy HOPE Statement ★ Support this podcast ★

6 Aug 53min

132. The Fellowship of the River with Dr Joe Tafur

132. The Fellowship of the River with Dr Joe Tafur

In this episode of the Drug Science Podcast, we meet with Dr. Joe Tafur, MD, an integrative Family Physician, curandero, author and speaker. He discusses his book, The Fellowship of the River, exploring the role of spiritual healing in modern healthcare. Within this episode. Tafur further delves into topics such as biological and psychological links to Generational trauma as well as the relationship between spiritual practice and healing.  Dr Joe TafurModern SpiritMedicine SongFellowship of the riverIntro into Therapeutic psychedelicsDepressionPeyoteAyahuascaEmotional dysregulationMamosInner childPsoriasis MigraineAllostatic loadAllostasis EpigeneticsMeditationSupport the Podcast Link ★ Support this podcast ★

23 Juli 1h 8min

Populärt inom Vetenskap

p3-dystopia
paranormalt-med-caroline-giertz
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
rss-vetenskapligt-talat
kapitalet-en-podd-om-ekonomi
dumforklarat
rss-vetenskapspodden
rss-ufobortom-rimligt-tvivel
bildningspodden
medicinvetarna
det-morka-psyket
sexet
halsorevolutionen
rss-vetenskapsradion-2
rss-spraket
vetenskapsradion
rss-personlighetspodden
barnpsykologerna