302 | Chris Kempes on the Biophysics of Evolution

302 | Chris Kempes on the Biophysics of Evolution

Randomness plays an important role in the evolution of life (as my evil twin will tell you). But random doesn't mean arbitrary. Biological organisms are physical objects, after all, and subject to the same laws of physics as non-biological matter is. Those laws place constraints on how organisms can fulfill their basic functions of metabolism, reproduction, motility, and so on. Easy to say, but how can we turn this into quantitative understanding of actual organisms? Today I talk with physical biologist Chris Kempes about how physics can help us understand the size of organisms, their metabolisms, and features of major transitions in evolution.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/20/302-chris-kempes-on-the-biophysics-of-evolution/

Chris Kempes received his Ph.D. in physical biology from the Massachusetts Institute of Technology. He is currently Professor and a member of the Science Steering Committee at the Santa Fe Institute. His research involves the origin of life and the constraints placed by physics on biological function and evolution.


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348 | Jessica Riskin on Jean-Baptiste Lamarck and Life as Creative Agency

348 | Jessica Riskin on Jean-Baptiste Lamarck and Life as Creative Agency

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23 Mars 1h 15min

347 | Andrew Guthrie Ferguson on How Your Data Will Be Used Against You

347 | Andrew Guthrie Ferguson on How Your Data Will Be Used Against You

In the 18th century, philosopher Jeremy Bentham suggested the Panopticon as a model of a prison where inmates could be constantly observed by just a single prison guard. Although his original idea was...

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346 | Erica Cartmill on How Human and Animal Minds Think and Play

346 | Erica Cartmill on How Human and Animal Minds Think and Play

Intelligence is a many splendored thing, especially when it comes to comparisons between species. Chimpanzees are better than humans at some numerical tasks, but less good at understanding what number...

9 Mars 1h 28min

AMA | March 2026

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Welcome to the March 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patre...

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345 | Adam Elga on Being Rational in a Very Large Universe

345 | Adam Elga on Being Rational in a Very Large Universe

Behaving rationally involves facing up to conditions of uncertainty; we never navigate the world with perfect confidence. Sometimes we are uncertain about the way the world is, but we can also be unce...

23 Feb 1h 34min

344 | Adam Gurri on Liberal Democracy and How to Fight For It

344 | Adam Gurri on Liberal Democracy and How to Fight For It

It's possible to look at the course of history over the past few centuries and discern a movement toward increasing democracy, freedom, and individual rights -- "liberalism," in the political-philosop...

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343 | Tom Griffiths on The Laws of Thought

343 | Tom Griffiths on The Laws of Thought

For all that human beings spend a lot of their time thinking, it's far from obvious what that process actually entails. Part of it amounts to classical logical reasoning. But an even bigger part invol...

9 Feb 1h 19min

AMA | Feb 2026

AMA | Feb 2026

Welcome to the February 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Pa...

2 Feb 3h 10min

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