Episode 945: Ketorolac vs. Ibuprofen

Episode 945: Ketorolac vs. Ibuprofen

Contributor: Ricky Dhaliwal, MD

Educational Pearls:

  • Ketorolac and ibuprofen are NSAIDs with equivalent efficacy for pain in the emergency department

    • Oral ibuprofen provides the same relief as intramuscular ketorolac

    • IM ketorolac is associated with the adverse effect of a painful injection

    • IM ketorolac is slightly faster in onset but not significant

    • Studies have assessed the two medications in head-to-head randomized-controlled trials and found no significant difference in pain scores

  • IM ketorolac takes longer to administer and has a higher cost

  • Ketorolac dosing

    • Commonly given in 10 mg, 15 mg, and 30 mg doses

    • However, higher doses are associated with more adverse effects

      • Gastrointestinal upset, nausea, and bleeding risk

    • Studies have demonstrated equal efficacy in pain reduction with lower doses

References

  1. Motov S, Yasavolian M, Likourezos A, et al. Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2017;70(2):177-184. doi:10.1016/j.annemergmed.2016.10.014

  2. Neighbor ML, Puntillo KA. Intramuscular ketorolac vs oral ibuprofen in emergency department patients with acute pain. Acad Emerg Med. 1998;5(2):118-122. doi:10.1111/j.1553-2712.1998.tb02595.x

Summarized & Edited by Jorge Chalit, OMS3

Donate: https://emergencymedicalminute.org/donate/

Avsnitt(1150)

Podcast 999: Right vs Left Internal Jugular Access

Podcast 999: Right vs Left Internal Jugular Access

Contributor: Travis Barlock, MD Educational Pearls: What is an internal jugular catheter (IJ) and when do we use it? IJs are catheters that can be placed in either the left or the right internal jugu...

23 Mars 2min

Podcast 998: Delayed Intubation After an Overdose

Podcast 998: Delayed Intubation After an Overdose

Contributor: Aaron Lessen, MD Educational Pearls: How long do we need to watch patients with a presumed overdose who were treated with naloxone in the field? A 2025 study in the Annals of Emergency M...

16 Mars 3min

Podcast 997: D-Dimer

Podcast 997: D-Dimer

Contributor: Travis Barlock, MD Educational Pearls: D-dimer: fibrin degradation product used to evaluate for clot formation and breakdown Threshold: Elevated D-dimer indicates recent or ongoing int...

9 Mars 2min

Podcast 996: Melatonin

Podcast 996: Melatonin

Contributor: Taylor Lynch MD Educational Pearls: Melatonin is an endogenous hormone released primarily by the pineal gland Also released by extrapineal regions in the retina, the GI tract, and some ...

2 Mars 4min

Episode 995: UTI Diagnosis

Episode 995: UTI Diagnosis

Contributor: Travis Barlock, MD Educational Pearls:  Foul-smelling urine and cloudy urine are commonly misinterpreted as indicators of a UTI. However, these findings alone are not diagnostic. Criteri...

24 Feb 5min

Podcast 994: Biphasic Anaphylaxis

Podcast 994: Biphasic Anaphylaxis

Contributor: Aaron Lessen, MD Educational Pearls: What is anaphylaxis and what are its treatments?  Anaphylaxis is a broad term for potentially life threatening allergic reactions that can progress t...

16 Feb 3min

Podcast 993: Personalized Gene Editing Therapy

Podcast 993: Personalized Gene Editing Therapy

Contributor: Alec Coston, MD Educational Pearls: Disclaimer: this has nothing to do with the ER but is too cool to not talk about. Condition: Carbamoyl phosphate synthetase 1 (CPS1) deficiency Ra...

9 Feb 6min

Tox Talks 2025 Recap 2, Methemoglobinemia and Errors

Tox Talks 2025 Recap 2, Methemoglobinemia and Errors

Contributors: Travis Barlock MD, Ian Gillman PA, Jacob Altholz MD, Jeffrey Olson MS4 In this episode, EM attending Travis Barlock and medical student Jeffrey Olson listen in to the two remaining cases...

4 Feb 41min

Populärt inom Vetenskap

dumma-manniskor
p3-dystopia
svd-nyhetsartiklar
kapitalet-en-podd-om-ekonomi
allt-du-velat-veta
rss-ufo-bortom-rimligt-tvivel-2
rss-vetenskapsradion-2
rss-vetenskapsradion
det-morka-psyket
sexet
doden-hjarnan-kemisten
rss-spraket
rss-odla
paranormalt-med-caroline-giertz
dumforklarat
rss-experimentet
medicinvetarna
vetenskapsradion
rss-geopodden-2
bildningspodden