#17  How the $101M XPRIZE will reverse aging by 20 years | Jamie Justice
LEVITY11 Feb 2025

#17 How the $101M XPRIZE will reverse aging by 20 years | Jamie Justice

Jamie Justice takes us inside the $101M XPRIZE Healthspan competition - one of the world's largest efforts to develop therapeutics that could reverse aging.

As Executive Vice President of XPRIZE Healthspan, Jamie reveals how teams must demonstrate they can restore muscle, cognitive, and immune function in older adults within just one year. The stakes? $81M for achieving a 20-year reversal of aging markers, with $71M and $61M prizes for lesser but still remarkable achievements.

Jamie shares her fascinating journey from studying crickets' lifespans in elementary school to leading groundbreaking aging research, including work on the TAME trial with metformin. She explains why they chose these specific biological systems to measure, how they'll determine success, and what kinds of interventions teams are exploring - from repurposed drugs to gene therapies.

We discuss:


* Why Peter Diamandis pushed for more ambitious goals

* How over 550 teams from 55 countries are approaching the challenge EDIT: Since we recorded this in late 2024 they've now reached over 600 teams.

* The role of biomarkers in measuring aging

* Why they chose to measure actual restoration rather than just preventing decline

* The challenges and opportunities in aging clinical trials

* Her vision for an integrated, multi-generational society that values aging populations


🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership


🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/


CHAPTERS:

00:00 Introduction

03:00 background

21:30 XPRIZE sculpted by experience

25:20 Collaborating with the entrant teams

29:00 Why muscle, mind and immune functions as targets

36:30 What if no one wins in 7-years?

41:05 Investors attracted

45:01 Does this give us increased longevity?

51:05 What kind of approaches have been entered?

01:00:30 AI

01:09:20 Composit end-points

01:13:10 TAME trial stuck because ...

01:19:10 Biomarkers of aging

01:26:50 AI and Biomarkers

01:29:02 The longbio track (be lucky)

01:36:20 Optimism about what?

01:41:00 3 book you have to read

🗞️ SUBSCRIBE to the LEVITY newsletter: reachlevity.com/subscribe

Get all LEVITY DeSci content here: reachlevity.com/t/desci (sorry about the wrong link in the episode)


📕 Check out Patrick's book: https://mitpress.mit.edu/9780262543163/the-case-against-death/

📗 Check out Peter's book (only available in Swedish): https://www.adlibris.com/sv/bok/evigt-ung-min-och-manniskans-drom-om-ododligheten-9789179652524


-----


Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.com/subscribe


LEVITY is co-hosted by Patrick Linden, philosopher and author, and Peter Ottsjö, journalist and author.

Hosted on Acast. See acast.com/privacy for more information.

Avsnitt(39)

#37 The Anti-Catastrophe League

#37 The Anti-Catastrophe League

Tom Ough tells us about the Big Things that may end humanity - and what we can do and in some cases have done to prevent these. Did you know that if all the risks, the one that is most likely to end y...

16 Dec 202544min

#36 How crypto is sparking a longevity frenzy

#36 How crypto is sparking a longevity frenzy

Today we’re diving into one of the strangest and most ambitious ideas in longevity: using crypto trading to fund real-time lifespan experiments.Benji Leibowitz, founder of pump.science, joins us to ex...

2 Dec 20251h 48min

#35 The Anti-Aging Uprising: Felix Werth’s Political Attack on Death Itself

#35 The Anti-Aging Uprising: Felix Werth’s Political Attack on Death Itself

Valuable time is being lost because there is not enough funding for science with real life-extending potential. No major political party is promising to address aging, even though aging harms and kill...

11 Nov 20251h 24min

#34 Biomarkers of aging: How close are we, really? - A conversation with Sara Hägg

#34 Biomarkers of aging: How close are we, really? - A conversation with Sara Hägg

Sara Hägg, PhD is an associate professor at Karolinska Institutet, where she leads the Molecular Epidemiology of Aging Group. Her work focuses on human biomarkers of aging - especially biological age ...

28 Okt 20251h 36min

#33 “Can death be the answer?"  A conversation with philosopher Nicholas Agar

#33 “Can death be the answer?" A conversation with philosopher Nicholas Agar

We are always excited about the next technological solution. But what if it does not come? Or what if it comes only for the few, or with terrible side-effects? And while we are waiting for the easy te...

7 Okt 20251h 44min

#32 “Medical malpractice”: Matt Kaeberlein on biological age tests

#32 “Medical malpractice”: Matt Kaeberlein on biological age tests

One idea I’ve had lately is to put together a list of people to trust in geroscience and the longevity field more broadly. (And I might do it - keep an eye on reachlevity.com- and subscribe while you’...

23 Sep 20251h 50min

# 31 He wants to save your pet with cryo - The Kai Micah Mills interview

# 31 He wants to save your pet with cryo - The Kai Micah Mills interview

When you give a child a pet, you also expose them to death—since most pets pass away long before their owners. But what if we could cryopreserve Buddy or Tiger, and bring them back from suspended anim...

9 Sep 20252h 8min

#30 Soon you'll take a drug designed by AI  | Alex Zhavoronkov

#30 Soon you'll take a drug designed by AI | Alex Zhavoronkov

As you may have heard, AI-designed medicines have crossed a historic line. In this episode, Alex Zhavoronkov - CEO of Insilico Medicine and founder of ARDD walks us through how Insilico’s rentosertib ...

26 Aug 20252h 13min

Populärt inom Vetenskap

dumma-manniskor
p3-dystopia
svd-nyhetsartiklar
allt-du-velat-veta
rss-ufo-bortom-rimligt-tvivel
kapitalet-en-podd-om-ekonomi
bildningspodden
rss-vetenskapsradion-2
det-morka-psyket
halsorevolutionen
4health-med-anna-sparre
sexet
rss-tidsmaskinen
dumforklarat
rss-utblick
naturmorgon
rss-geopodden-2
rss-experimentet
rss-vetenskapsradion
paranormalt-med-caroline-giertz