#157 - AMA #22: Losing fat and gaining fat: the lessons of fat flux
The Peter Attia Drive12 Apr 2021

#157 - AMA #22: Losing fat and gaining fat: the lessons of fat flux

In this "Ask Me Anything" (AMA) episode, Peter and Bob take a deep dive into fat flux. They define the major players that impact the flow of fat entering and exiting a fat cell, which determines how much fat a person carries. They discuss the significant influence that insulin has on the net fat balance and explore common strategies, such as fasting and low-carb diets, that have efficacy in the liberation and oxidation of fat from fat cells. Additionally, Bob explains his research process and how he seeks answers to Peter's challenging questions.

If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #22 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

  • The two main ways to reduce fat mass (1:30);
  • Explaining fat flux—how fat enters and exits a fat cell (9:15);
  • What fat balance looks like (21:15);
  • What net fat influx looks like, and the impact of insulin in lipolysis (24:30);
  • What net fat efflux looks like, and the benefits of fasting to break the hyperinsulinemic cycle (28:30);
  • Exploring why most people with excess body fat will lose fat mass when reducing carbohydrates or eating a ketogenic diet (32:45);
  • Why being in nutritional ketosis does not automatically translate to negative fat flux (fat loss) (42:40);
  • Bob's approach to scientific research (47:00);
  • The importance of curiosity and a desire to learn (58:30);
  • Bob's tips and tricks for answering a scientific question in a time-crunch (1:00:00); and
  • More.

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Show notes page for this episode: https://peterattiamd.com/ama22/

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