#381: Better Than Lasers: NAD+, Spermidine, and Methylene Blue for Youthful Skin | Amitay Eshel and Anastasia Khodzhaeva

Today, I'm joined by the pioneering duo behind Young Goose and two of the earliest voices to bring longevity science into the world of skincare. Amitay comes from the red light therapy space, while Anastasia's background is rooted in cancer research and regenerative medicine—together, their bold thesis is that youthful skin is not just about appearance, it's an energy state. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. Episode Timestamps: Skin longevity: appearance vs resilience vs long-term health ... 00:06:42 Why topical NAD matters for skin ... 00:14:07 Importance and decline of NAD as we age ... 00:18:26 Why spermidine was added to skincare ... 00:21:00 How spermidine drives autophagy and hydration ... 00:25:43 Spermidine's impact on wrinkles and skin barrier ... 00:29:06 Longevity skincare vs traditional approaches ... 00:31:18 Methylene blue's unique benefits and formulation ... 00:34:04 Methylene blue vs other antioxidants ... 00:36:16 Methylene blue's role in recovery and protection ... 00:46:13 Platelet-derived, quantified exosomes explained ... 00:51:44 How to layer exosomes in your skincare ... 01:01:13 Biggest myths in skin longevity ... 01:02:41 Does topical NAD and spermidine really work? ... 01:08:28 Where to start with Young Goose products ... 01:19:33 Our Amazing Sponsors: Digestive Bitters by Just Thrive - One capsule before eating helps your body absorb more nutrients, ease digestion, and leave you feeling light instead of weighed down. Head over to Justthrivehealth.com/discount/NAT and use code NAT20 for 20% off. Puori: It's minimally processed, made from pasture-raised cows' milk, and it's tested for over 200 contaminants every single batch. It's also very Yummy! Go to Puori.com/NAT and use code NAT for 20% off— it also applies to subscriptions so you'll get nearly a third off the price. Thymus & Pineal BioRegulators by Natures Marvels - Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. Pineal Bioregulator supports your natural melatonin/circadian rhythm so you get the kind of sleep that underpins immune resilience. Head to profound-health.com and use code LONGEVITY15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group