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What are the biggest questions in science today: Can we cure cancer, solve the climate crisis, make it to Mars? For Nobel laureate Jack Szostak, the biggest question is still much more fundamental: What is the origin of life? A professor of genetics at Harvard University, Szostak has dedicated his lab to piecing together the complex puzzle of life’s origins on Earth. The story takes us back billions of years and may provide answers to some of our most mysterious questions: Where did we come from—and are we alone in the universe?