#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!

This episode is brought to you by:

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Coyote the card game​, which I co-created with Exploding Kittens: https://coyotegame.com

Timestamps:

• [00:00:00] Start.
• [00:00:52] Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
• [00:07:12] My recent adventures in accelerated TMS and bioelectric medicine.
• [00:21:09] The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
• [00:24:23] Aphantasia vs. hyperphantasia, and Joshua Waitzkin's ability to "feel" chess.
• [00:33:12] DORAs for sleep and Alzheimer's prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
• [00:41:21] Dale Bredesen's kitchen-sink approach to dementia and the ketogenic connection.
• [00:46:22] The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
• [00:49:40] Google's full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
• [00:52:50] The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
• [00:58:05] Kevin's three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
• [01:02:05] Holiday gift ideas and recommended reading.
• [01:17:41] The Way App and meditation with Zen master Henry Shukman.
• [01:21:44] Kevin's AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
• [01:26:58] Oboe.fyi: The AI learning platform and my investment philosophy.
• [01:32:09] My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
• [01:38:17] Terry Real's relationship wisdom: Why objective reality has no place in an argument.
• [01:47:18] Dog updates: Molly, a new puppy, and Toaster on rapamycin.
• [01:47:58] Parting thoughts and happy holidays.

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