EPISODE 2: Spaceflight, Muscle Loss & Worms – How Microgravity Reshapes Biology

EPISODE 2: Spaceflight, Muscle Loss & Worms – How Microgravity Reshapes Biology

In this episode, we explore how microgravity affects muscle structure and function, using Caenorhabditis elegans as a model organism. Spaceflight-induced muscle atrophy is a major challenge for astronauts, and understanding the molecular and genetic mechanisms behind these changes is key to developing countermeasures.


This discussion is based on the review article:

“Advancing Insights into Microgravity-Induced Muscle Changes Using Caenorhabditis elegans as a Model Organism”

Beckett LJ, Williams PM, Toh LS, Hessel V, Gerstweiler L, Fisk I, Toronjo-Urquiza L, Chauhan VM. Published in npj Microgravity (2024).

📖 Read the full paper: ⁠https://doi.org/10.1038/s41526-024-00418-z⁠


🔬 Learn how C. elegans provides unique insights into metabolic changes, gene expression, and protein regulation during spaceflight, offering potential strategies to counteract muscle degradation.


🌍 Follow for more research-based discussions on nematodes, space biology, and biomedical science.


This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.


📩 More info:

🔗 www.veerenchauhan.com

📧 veeren.chauhan@nottingham.ac.uk

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Jaksot(53)

EPISODE 53: Worms on Pause

EPISODE 53: Worms on Pause

Welcome to the next episode of the WOrM Podcast 🪱⏸️Today, we are talking about worms that appear to stop living—without dying.Researchers have identified a new, reversible state of suspended animatio...

5 Elo 26min

EPISODE 52: Worms in Space: Microbiomes in a Capsule

EPISODE 52: Worms in Space: Microbiomes in a Capsule

Welcome to the next episode of the WOrM Podcast 🪱🚀Today, we are looking at NemaCapsules: a new microfluidic system designed to study how host genetics and the gut microbiome influence C. elegans hea...

29 Heinä 21min

EPISODE 51: The Worm Behind the Wild

EPISODE 51: The Worm Behind the Wild

Welcome to the next episode of the WOrM Podcast 🪱Today we’re looking at a review with a bold idea.Can a tiny nematode help us protect fish, amphibians, reptiles and insects from an increasingly chall...

22 Heinä 16min

EPISODE 50: Fed by Mum, Built by Ribosomes

EPISODE 50: Fed by Mum, Built by Ribosomes

Welcome to the next episode of the WOrM Podcast 🪱Today we’re talking about inheritance.Not DNA.Not small RNAs.Not epigenetics.But ribosomes.⸻🧬 The central ideaWhen mother worms experience dietary re...

15 Heinä 20min

EPISODE 49: Glowing up the Worm Proteome

EPISODE 49: Glowing up the Worm Proteome

Welcome to the next episode of the WOrM Podcast 🪱Today we’re looking at a paper that doesn’t answer a biological question.Instead, it builds the tools to answer thousands of biological questions in t...

8 Heinä 21min

EPISODE 48: Murder Mode: How a Worm Evolved the Urge to Kill

EPISODE 48: Murder Mode: How a Worm Evolved the Urge to Kill

Welcome to the next episode of the WOrM Podcast 🪱Today we're talking about a worm with teeth.And a nervous system that has been rewired — by evolution — to become aggressive.⸻🧬 The central ideaPrist...

6 Touko 14min

EPISODE 47: When Bacteria Fight Back: Bioplastic Kills the Worm

EPISODE 47: When Bacteria Fight Back: Bioplastic Kills the Worm

Welcome to the next episode of the WOrM Podcast 🪱Today we’re talking about something unexpected.A bioplastic — something we usually think of as sustainable, useful, even beneficial —can kill a worm.⸻...

29 Huhti 21min

EPISODE 46: Turning in Time: Neural Sequences in the Worm Brain

EPISODE 46: Turning in Time: Neural Sequences in the Worm Brain

Welcome to the next episode of the WOrM Podcast 🪱Today we’re looking at something deceptively simple: a turn.But not just that a worm turns —how the brain decides to do it.⸻🧬 The central ideaTurning...

22 Huhti 19min

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