WOrM Podcast: Whole Organism Analytics Podcast8 Loka 2025

EPISODE 30: Timelines of Ageing – What Worms Teach Us About Growing Old

In this episode, we dive into a new version of WormGazer as described in a recent GeroScience paper. This implementation automates movement monitoring in C. elegans populations as a rapid healthspan measure, offering a shortcut to detect ageing interventions and trade-offs.

Highlights include:

• Monitoring multiple Petri dishes in parallel with cameras and image analysis over 7–14 days

• Showing that most functional decline happens in the first week of adulthood

• Validating with age-1(hx546) mutants, which remain active longer but move more slowly early on

• A dose-response test with sulfamethoxazole (SMX) where movement improvements are detectable within 7 days, compared to 40 days needed for traditional lifespan assays

• The benefit: non-invasive, scalable, and faster detection of ageing effects and negative trade-offs

📖 Based on the research article:

“Rapid measurement of ageing by automated monitoring of movement of C. elegans populations”

Giulia Zavagno, Adelaide Raimundo, Andy Kirby, Christopher Saunter & David Weinkove

Published in GeroScience (November 2023)

🔗 https://doi.org/10.1007/s11357-023-00998-w

🎧 Subscribe to the WOrM Podcast for more breakthroughs in whole-organism ageing, automation, and quantitative biology.

This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info:

🔗 ⁠⁠www.veerenchauhan.com⁠⁠

📧 veeren.chauhan@nottingham.ac.uk

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(53)

EPISODE 53: Worms on Pause

Welcome to the next episode of the WOrM Podcast 🪱⏸️Today, we are talking about worms that appear to stop living—without dying.Researchers have identified a new, reversible state of suspended animatio...

5 Elo 26min

EPISODE 52: Worms in Space: Microbiomes in a Capsule

Welcome to the next episode of the WOrM Podcast 🪱🚀Today, we are looking at NemaCapsules: a new microfluidic system designed to study how host genetics and the gut microbiome influence C. elegans hea...

29 Heinä 21min

EPISODE 51: The Worm Behind the Wild

Welcome to the next episode of the WOrM Podcast 🪱Today we’re looking at a review with a bold idea.Can a tiny nematode help us protect fish, amphibians, reptiles and insects from an increasingly chall...

22 Heinä 16min

EPISODE 50: Fed by Mum, Built by Ribosomes

Welcome to the next episode of the WOrM Podcast 🪱Today we’re talking about inheritance.Not DNA.Not small RNAs.Not epigenetics.But ribosomes.⸻🧬 The central ideaWhen mother worms experience dietary re...

15 Heinä 20min

EPISODE 49: Glowing up the Worm Proteome

Welcome to the next episode of the WOrM Podcast 🪱Today we’re looking at a paper that doesn’t answer a biological question.Instead, it builds the tools to answer thousands of biological questions in t...

8 Heinä 21min

EPISODE 48: Murder Mode: How a Worm Evolved the Urge to Kill

Welcome to the next episode of the WOrM Podcast 🪱Today we're talking about a worm with teeth.And a nervous system that has been rewired — by evolution — to become aggressive.⸻🧬 The central ideaPrist...

6 Touko 14min

EPISODE 47: When Bacteria Fight Back: Bioplastic Kills the Worm

Welcome to the next episode of the WOrM Podcast 🪱Today we’re talking about something unexpected.A bioplastic — something we usually think of as sustainable, useful, even beneficial —can kill a worm.⸻...

29 Huhti 21min

EPISODE 46: Turning in Time: Neural Sequences in the Worm Brain

Welcome to the next episode of the WOrM Podcast 🪱Today we’re looking at something deceptively simple: a turn.But not just that a worm turns —how the brain decides to do it.⸻🧬 The central ideaTurning...

22 Huhti 19min