#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Jocko Willink is a retired Navy SEAL, co-author of Extreme Ownership, and host of Jocko Podcast. Please support this podcast by checking out our sponsors: - Linode: https://linode.com/lex to get $100 free credit - Indeed: https://indeed.com/lex to get $75 credit - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera - Ground News: https://ground.news/lex EPISODE LINKS: Jocko's Twitter: https://twitter.com/jockowillink Jocko's Website: https://jocko.com/ Jocko's Podcast: https://jockopodcast.com/ Extreme Ownership (book): https://amzn.to/3qYmcgh Discipline Equals Freedom (book): https://amzn.to/3hFXOMa The Dichotomy of Leadership (book): https://amzn.to/36ehH7C PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:01) - The beauty and tragedy of war (14:35) - Soviet Union in World War II (20:54) - What makes a just war? (34:30) - Jordan Peterson (37:42) - Fear of death (41:53) - Autonomous weapons systems (53:28) - What makes a great leader? (56:15) - Elon Musk - a leadership case study (1:10:03) - Steve Jobs - a leadership case study (1:20:16) - Sundar Pichai - a leadership case study (1:27:15) - Young Jamie (1:31:23) - Discipline (1:34:15) - A day in the life of Jocko (1:40:30) - Jiu Jitsu (1:56:18) - Books

5 Heinä 20212h 3min

Yeonmi Park is a North Korean defector, human rights activist, and author of the book In Order to Live. Please support this podcast by checking out our sponsors: - Belcampo: https://belcampo.com/lex and use code LEX to get 20% off first order - Gala Games: https://gala.games/lex - BetterHelp: https://betterhelp.com/lex to get 10% off - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Yeonmi's Twitter: https://twitter.com/YeonmiParkNK Yeonmi's Facebook: https://www.facebook.com/officialyeonmipark Yeonmi's YouTube: https://www.youtube.com/c/YeonmiParkOfficial In Order to Live (book): https://amzn.to/3wdtKfL PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:20) - Growing up in North Korea (14:45) - Animal Farm (21:00) - Search for meaning (25:48) - Love (28:05) - Language (32:28) - Yeonmi's dad (34:30) - Escaping North Korea (39:47) - The world is ignoring the genocide in North Korea (51:49) - Evil (54:40) - Nuclear war (55:30) - Marxist origins of North Korea (1:00:43) - Famine (1:05:30) - Kim Jong-un is pure evil (1:12:06) - Freedom (1:15:18) - Michael Malice (1:18:57) - Diversity (1:26:18) - Political correctness (1:35:50) - Jordan Peterson (1:40:01) - Michael Malice book on North Korea (1:45:31) - Advice for young people (1:48:33) - Facing assassination (1:58:47) - Siddhartha by Hermann Hesse (2:01:20) - Meaning of life

1 Heinä 20212h 6min

Clara Sousa-Silva is a quantum astrochemist at Harvard. Please support this podcast by checking out our sponsors: - Onnit: https://lexfridman.com/onnit to get up to 10% off - Grammarly: https://grammarly.com/lex to get 20% off premium - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Indeed: https://indeed.com/lex to get $75 credit EPISODE LINKS: Clara's Twitter: https://twitter.com/drphosphine Clara's Website: https://clarasousasilva.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:57) - Discovery of phosphine on Venus (20:34) - Phosphine gas (30:47) - Searching for molecular fingerprints (41:44) - What does a quantum astrochemist do? (56:48) - Spectroscopic networks (1:01:13) - Biosignature gases (1:04:06) - UFOs and aliens (1:17:24) - Alien civilizations (1:34:59) - Programming (1:42:15) - Why science is beautiful (1:46:07) - How to be productive (1:56:27) - Books (1:57:59) - Meaning of life

28 Kesä 20212h 4min

Bret Weinstein is and evolutionary biologist, author, and co-host of the DarkHorse Podcast. Please support this podcast by checking out our sponsors: - The Jordan Harbinger Show: https://www.youtube.com/thejordanharbingershow - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off EPISODE LINKS: Bret's Twitter: https://twitter.com/BretWeinstein Bret's YouTube: https://www.youtube.com/BretWeinsteinDarkHorse Bret's Website: https://bretweinstein.net/ Bret's Book: https://amzn.to/3dhVWrv PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:04) - Why biology is beautiful (16:38) - Boston Dynamics (20:02) - Being self-critical (30:09) - Theory of close calls (38:46) - Lab leak hypothesis (1:12:41) - Joe Rogan (1:21:50) - Censorship (1:58:40) - Vaccines (2:12:26) - The paper on mice with long telomeres (2:40:09) - Martyrdom (2:48:54) - Eric Weinstein (2:58:13) - Monogamy (3:10:31) - Advice for young people (3:17:16) - Meaning of life

25 Kesä 20213h 22min

Rob Reid is an author and podcaster. Please support this podcast by checking out our sponsors: - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Belcampo: https://belcampo.com/lex and use code LEX to get 20% off first order - Fundrise: https://fundrise.com/lex - NetSuite: http://netsuite.com/lex to get free product tour EPISODE LINKS: Rob's Twitter: https://twitter.com/rob_reid After On Podcast: https://after-on.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:33) - The most entertaining outcome is the most likely (14:52) - Meme theory (18:12) - Writing process (24:59) - Engineered viruses as a threat to human civilization (32:45) - Gain-of-function research on viruses (44:54) - Did COVID leak from a lab? (52:15) - Virus detection (1:00:04) - Failure of institutions (1:07:48) - Using AI to engineer viruses (1:12:07) - Evil and competence (1:21:26) - Where are the aliens? (1:25:19) - Backing up human consciousness by colonizing space (1:34:48) - Superintelligence and consciousness (1:46:12) - Meditation (1:54:20) - Fasting (2:00:20) - Greatest song of all time (2:05:46) - Early days of music streaming (2:17:39) - Startup advice (2:30:50) - Podcasting (2:46:12) - Advice for young people (2:55:15) - Mortality (3:00:41) - Meaning of life

21 Kesä 20213h 5min

Charles Hoskinson is the founder of Cardano, co-founder of Ethereum, a mathematician, and a farmer. Please support this podcast by checking out our sponsors: - Gala Games: https://gala.games/lex - Allform: https://allform.com/lex to get 20% off - Indeed: https://indeed.com/lex to get $75 credit - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Charles's Twitter: https://twitter.com/IOHK_Charles Charles's YouTube: https://www.youtube.com/user/charleshoskinson Cardano Website: https://cardano.org/ IOHK Website: https://iohk.io/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:12) - What programming language is the simulation written in? (14:17) - Favorite philosophers (23:18) - Theory vs engineering in cryptocurrency (34:27) - What programming languages should everyone learn (42:42) - Haskell and beyond (46:26) - Plutus: Cardano's smart contract platform based on Haskell (50:53) - What is a blockchain? (55:05) - Hybrid smart contracts (1:00:55) - Proof of work vs proof of stake (1:09:42) - Cardano's proof of stake consensus algorithm (1:20:14) - What is Cardano? (1:28:55) - Cardano vs Ethereum vs Bitcoin (1:38:50) - The problem with Bitcoin (1:48:24) - Bitcoin Conference (1:52:05) - Ergo and Alex Chepurnoy (1:59:15) - Cardano's Extended UTXO Model (2:06:27) - Chainlink and Oracle Networks (2:13:40) - Cardano and Wolfram Alpha (2:18:35) - The future of video games (2:27:10) - Smart contracts timeline for Cardano (2:34:40) - Decentralized exchanges (2:40:21) - Jack Dorsey and Bitcoin (2:46:33) - Elon Musk and Tesla: Cardano, Ethereum, Bitcoin (2:49:50) - Dogecoin and Elon Musk (3:01:11) - Hydra vs Lightning Network (3:08:45) - Non-Interactive Proofs of Proof-of-Work (NIPoPoWs) (3:12:39) - Cardano failure modes (3:21:00) - Cardano vs Polkadot (3:26:05) - Vitalik Buterin (3:34:16) - Corrupting nature of power (3:44:26) - Satoshi Nakamoto (3:50:37) - Cardano's vision for decentralized governance (4:03:31) - Cardano in Ethiopia (4:07:33) - El Salvador and Bitcoin (4:13:50) - Cryptocurrency will inject capitalism with long-term incentives (4:23:42) - Day in the life of Charles Hoskinson (4:30:59) - Mushrooms (4:37:07) - Joe Rogan (4:42:00) - Video games (4:54:14) - Advice for young people (4:57:23) - Meaning of life

16 Kesä 20215h 4min

Daniel Schmachtenberger is a philosopher interested understanding the rise and fall of societies and individuals. Please support this podcast by checking out our sponsors: - Ground News: https://ground.news/lex - NetSuite: http://netsuite.com/lex to get free product tour - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Daniel's Website: https://civilizationemerging.com/ The Consilience Project: https://consilienceproject.org/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:05) - Aliens and UFOs (26:50) - Collective intelligence of human civilization (34:46) - Consciousness (46:08) - How much computation does the human brain perform? (49:47) - Humans vs ants (57:04) - Humans are apex predators (1:04:08) - Girard's Mimetic Theory of Desire (1:24:05) - We can never completely understand reality (1:27:29) - Self-terminating systems (1:37:52) - Catastrophic risk (2:08:04) - Adding more love to the world (2:35:29) - How to build a better world (2:52:41) - Meaning of life (3:00:23) - Death (3:06:04) - The role of government in society (3:23:29) - Exponential growth of technology (4:09:10) - Lessons from my father (4:14:46) - Even suffering is filled with beauty

14 Kesä 20214h 21min

Jordan Ellenberg is a mathematician and author of Shape and How Not to Be Wrong. Please support this podcast by checking out our sponsors: - Secret Sauce: https://wondery.com/shows/secret-sauce/ - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Indeed: https://indeed.com/lex to get $75 credit EPISODE LINKS: Jordan's Website: http://www.jordanellenberg.com Jordan's Twitter: https://twitter.com/JSEllenberg PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:44) - Mathematical thinking (10:21) - Geometry (14:58) - Symmetry (25:29) - Math and science in the Soviet Union (33:09) - Topology (47:57) - Do we live in many more than 4 dimensions? (52:28) - How many holes does a straw have (1:01:53) - 3Blue1Brown (1:07:40) - Will AI ever win a Fields Medal? (1:16:05) - Fermat's last theorem (1:33:23) - Reality cannot be explained simply (1:39:08) - Prime numbers (2:00:37) - John Conway's Game of Life (2:12:29) - Group theory (2:15:45) - Gauge theory (2:23:47) - Grigori Perelman and the Poincare Conjecture (2:33:59) - How to learn math (2:41:08) - Advice for young people (2:43:13) - Meaning of life

13 Kesä 20212h 47min