#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Sergey Nazarov is the Co-Founder of Chainlink, a decentralized oracle network that provides data to smart contracts. Please support this podcast by checking out our sponsors: - Wine Access: https://wineaccess.com/lex to get 20% off first order - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off - Indeed: https://indeed.com/lex to get $75 credit - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Sergey's Twitter: https://twitter.com/SergeyNazarov Chainlink Website: https://chain.link/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:56) - Hedgy (08:22) - Digital vs physical world (16:16) - Definitive truth (20:31) - Decentralized finance (29:00) - Smart contracts (35:16) - Hybrid smart contracts and oracle networks (52:02) - Applications of smart contracts (1:10:08) - AI and smart contracts (1:17:40) - What agreements can be turned into smart contracts? (1:28:43) - Privacy (1:39:01) - Trust (1:54:36) - Bitcoin (2:02:50) - Satoshi Nakamoto (2:10:10) - Ethereum (2:15:59) - Chainlink design decisions (2:28:27) - Dogecoin (2:32:44) - Book recommendations (2:44:54) - Advice for young people (2:56:58) - Meaning of life

1 Touko 20210s

Jeremi Suri is a historian at UT Austin. Please support this podcast by checking out our sponsors: - LMNT: https://drinkLMNT.com/lex to get free sample pack - Munk Pack: https://munkpack.com and use code LEX to get 20% off - Belcampo: https://belcampo.com/lex and use code LEX to get 20% off first order - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Jeremi's Twitter: https://twitter.com/JeremiSuri Jeremi's Website: http://jeremisuri.net This is Democracy Podcast: http://jeremisuri.net/archives/1798 The Impossible Presidency (book): https://amzn.to/2QKC5Jp PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (14:33) - Power of charisma (20:24) - US presidency (31:10) - Aliens (36:17) - Bill Clinton (39:07) - Students of history (43:58) - George Washington (46:44) - Putin (53:27) - FDR (1:08:39) - Henry Kissinger (1:18:32) - Realpolitik (1:30:22) - What is a just war? (1:36:27) - Cold war (1:40:44) - Communism in the United States (1:50:42) - Vaccines and the future of the human species (1:55:57) - Book recommendations (1:57:31) - Learning another language (2:01:58) - Advice for young people (2:08:10) - Grandmother (2:11:03) - Meaning of life

30 Huhti 20212h 14min

Georges St-Pierre is a martial artist. Please support this podcast by checking out our sponsors: - Allform: https://allform.com/lex to get 20% off - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Theragun: https://theragun.com/lex to get 30 day trial - The Information: https://theinformation.com/lex to get 75% off first month EPISODE LINKS: GSP's Twitter: https://twitter.com/GeorgesStPierre GSP's Instagram: https://www.instagram.com/georgesstpierre/ GSP's Facebook: https://www.facebook.com/georgesstpierre GSP's Website: https://www.gspofficial.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:09) - Love of winning (11:01) - Suffering (12:03) - Fasting (22:01) - Carnivore (28:30) - Fear (36:02) - Strategy (39:12) - Mind games (42:54) - Mental games (48:00) - Science of fighting (1:11:39) - GOAT (1:15:22) - A fight vs Khabib (1:25:03) - Free will (1:28:49) - Consciousness (1:31:05) - AI (1:41:13) - Aliens (1:52:21) - Dreams (1:57:55) - Father (2:02:58) - Life and love (2:17:07) - Advice for young people (2:19:28) - How to learn (2:22:55) - Bruce Lee (2:26:04) - Tie choke (2:32:49) - Best martial art for self-defense (2:37:28) - Meaning of life

26 Huhti 20210s

Michael Malice is an anarchist. Yaron Brook is an objectivist. Both are podcasters and authors. Please support this podcast by checking out our sponsors: - Ground News: https://ground.news/lex - Public Goods: https://publicgoods.com/lex and use code LEX to get $15 off - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Brave: https://brave.com/lex - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off EPISODE LINKS: Michael's Twitter: https://twitter.com/michaelmalice Michael's Community: https://malice.locals.com/ Michael's YouTube: https://www.youtube.com/channel/UC5tj5QCpJKIl-KIa4Gib5Xw Michael's Website: http://michaelmalice.com/about/ Yaron's Twitter: https://twitter.com/yaronbrook Yaron's YouTube: https://www.youtube.com/user/ybrook Yaron's Website: https://yaronbrookshow.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:43) - Desert island thought experiment (15:00) - Communism (18:30) - Immanuel Kant (19:39) - Donald Hoffman (30:10) - DMT elves (38:52) - Humility (55:45) - Jordan Peterson and religion (1:05:23) - Ben Shapiro: facts don't care about your feelings (1:19:23) - Why Ayn Rand is controversial (1:41:01) - Selfishness (1:44:43) - Communism and fascism (2:11:42) - Authoritarianism (2:20:02) - Bitcoin (2:46:13) - Anarchy debate (3:44:08) - Dangers of communism (3:49:47) - Favorite character in Ayn Rand s Atlas Shrugged (3:58:25) - Advice for young people (4:15:24) - Does love require sacrifice? (4:23:12) - Back to the island

24 Huhti 20210s

Risto Miikkulainen is a computer scientist at UT Austin. Please support this podcast by checking out our sponsors: - The Jordan Harbinger Show: https://jordanharbinger.com/lex/ - Grammarly: https://grammarly.com/lex to get 20% off premium - Belcampo: https://belcampo.com/lex and use code LEX to get 20% off first order - Indeed: https://indeed.com/lex to get $75 credit EPISODE LINKS: Risto's Website: https://www.cs.utexas.edu/users/risto/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:51) - If we re-ran Earth over 1 million times (10:08) - Would aliens detect humans? (12:46) - Evolution of intelligent life (16:31) - Fear of death (22:47) - Hyenas (26:12) - Language (29:43) - The magic of programming (35:43) - Neuralink (43:15) - Surprising discoveries by AI (46:49) - How evolutionary computation works (58:12) - Learning to walk (1:01:25) - Robots and a theory of mind (1:10:29) - Neuroevolution (1:20:47) - Tesla Autopilot (1:24:11) - Language and vision (1:29:53) - Aliens communicating with humans (1:35:29) - Would AI learn to lie to humans? (1:42:03) - Artificial life (1:46:56) - Cellular automata (1:52:32) - Advice for young people (1:57:09) - Meaning of life

19 Huhti 20212h 2min

Robert Breedlove is a decentralized finance entrepreneur, philosopher, and podcaster. Please support this podcast by checking out our sponsors: - Fundrise: https://fundrise.com/lex - LMNT: https://drinkLMNT.com/lex to get free sample pack - Munk Pack: https://munkpack.com and use code LEX to get 20% off - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Robert's Twitter: https://twitter.com/Breedlove22 Robert's Linktree: https://linktr.ee/breedlove22 What is Money Show: https://www.youtube.com/c/RobertBreedlove22 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:46) - Sovereignty (15:50) - Territorial imperative (20:28) - Property (26:33) - Anarchism (29:11) - Inflation is theft (33:35) - Volatility is truth (38:14) - Taleb and Bitcoin (42:22) - Life is information propagating through flesh (53:21) - Intelligence (57:34) - Space and time (1:04:16) - Pragmatic truth (1:15:14) - Creative destruction (1:19:03) - Capitalism vs Communism (1:31:46) - Jordan Peterson on religion (1:36:03) - Inflation (1:39:54) - What is money? (1:53:30) - What is Bitcoin? (2:04:36) - Bitcoin vs other cryptocurrencies (2:12:47) - Can governments ban Bitcoin? (2:25:29) - Bitcoin toxicity is tough love (2:38:47) - Crypto scammers (2:47:58) - Eric Weinstein and Bitcoin (2:54:21) - Satoshi Nakamoto (2:58:51) - Money is energy (3:06:05) - Proof of stake vs proof of work (3:08:45) - Morality (3:23:30) - Collapse of the Soviet Union (3:27:00) - Jordan Peterson and Bitcoin (3:39:28) - Book recommendations (3:58:49) - Advice for young people (4:02:20) - Love

17 Huhti 20214h 9min

Yannis Pappas is a comedian and podcaster. Please support this podcast by checking out our sponsors: - Wine Access: https://wineaccess.com/lex to get 20% off first order - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off - Indeed: https://indeed.com/lex to get $75 credit EPISODE LINKS: Yannis's Twitter: https://twitter.com/yannispappas Long Days Podcast: https://www.youtube.com/channel/UCywn6iboO1P8U7fotfllocw Stand Up Special: https://www.youtube.com/watch?v=R156F0uXhzk PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:39) - Tim Dillon and absolute power (16:00) - Mortality (24:01) - Immortality (31:47) - Dogs (38:26) - Power (43:46) - Hyenas (49:00) - Nature is metal (51:53) - Battle of Crete (59:21) - History is written by the victors (1:04:09) - History Hyenas podcast (1:16:18) - Bernie Madoff (1:19:23) - Jeffrey Epstein (1:24:16) - Hitler (1:26:24) - Conspiracy theories (1:29:34) - Andrew Yang and New York City (1:33:01) - Podcast with Lex's dad (1:36:09) - Andrew Yang and the prison-industrial complex (1:41:57) - Queen Elizabeth (1:49:04) - Advice for young people

12 Huhti 20211h 57min

Tyler Cowen is an economist, writer, and podcaster. Please support this podcast by checking out our sponsors: - Linode: https://linode.com/lex to get $100 free credit - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera - Public Goods: https://publicgoods.com/lex and use code LEX to get $15 off EPISODE LINKS: Tyler's Twitter: https://twitter.com/tylercowen Tyler's Blog: https://marginalrevolution.com/ Conversations with Tyler (Podcast): https://conversationswithtyler.com/ Big Business (Book): https://amzn.to/2OBPbaK Tyler's Wiki: https://en.wikipedia.org/wiki/Tyler_Cowen PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:24) - Economics (09:16) - Nuclear war (16:03) - The American dream (23:16) - Capitalism: pros and cons (29:50) - Is competition good for the world? (31:53) - Free market (32:57) - Anarchy (35:23) - Ayn Rand (40:04) - The case for big business (44:31) - Clubhouse (49:35) - Loneliness (51:47) - Eric Weinstein and economic growth (56:08) - Communism (58:58) - Putin (1:04:29) - China (1:09:21) - UBI (1:13:17) - Disagreement with Eric Weinstein (1:17:09) - Money, Bitcoin, and Ethereum (1:25:20) - WallStreetBets (1:29:16) - MIT (1:36:44) - UFO sightings (1:44:03) - Contemporary art is misunderstood (1:51:06) - Mexican food is the best in the world (1:55:56) - Jiro Dreams of Sushi (1:59:59) - Book recommendations (2:02:15) - Advice for young people (2:05:53) - Love (2:11:35) - Mortality (2:13:25) - Meaning of life

10 Huhti 20212h 15min