ASH 2025 | Pivekimab sunirine + Ven + Aza in unfit patients with ND CD123+ AML: Phase Ib/II efficacy and safety
AML Hub13 Tammi

ASH 2025 | Pivekimab sunirine + Ven + Aza in unfit patients with ND CD123+ AML: Phase Ib/II efficacy and safety

Following the 67th American Society of Hematology (ASH) Annual Meeting and Exposition, December 6–9, 2025, Orlando, US, the AML Hub was pleased to speak with Gail Roboz, Weill Cornell Medicine, New York, US. We asked, What are the latest findings from clinical trials of pivekimab sunirine in unfit patients with newly diagnosed acute myeloid leukemia (AML)?


In this interview, Roboz discusses key findings from a preliminary subgroup analysis of a phase Ib/II trial (NCT04086264), investigating the anti-CD123 antibody–drug conjugate pivekimab sunirine in combination with azacitidine and venetoclax, for ≥14 days or 28 days, in unfit patients with newly diagnosed CD123-positive AML. The primary endpoint was antileukemic activity, including complete remission (CR) and composite CR with incomplete hematologic recovery (CR/CRi) rates.


This educational resource is independently supported by AbbVie. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource.

Hosted on Acast. See acast.com/privacy for more information.

Jaksot(33)

What are the challenges associated with CAR T-cell therapy in patients with AML?

What are the challenges associated with CAR T-cell therapy in patients with AML?

During the 6th European CAR T-Cell Meeting, the AML Hub spoke to Sarah Tettamanti, Tettamanti Foundation Research Center, Monza, IT. We asked, What are the challenges associated with CAR T-cell therap...

25 Huhti 20249min

How might the MORPHO trial of gilteritinib impact clinical practice?

How might the MORPHO trial of gilteritinib impact clinical practice?

The AML Hub spoke to Charles Craddock, Queen Elizabeth Hospital Birmingham, Birmingham, UK at ASH 2023. We asked, How might the MORPHO trial of gilteritinib impact clinical practice? Hosted on Acast. ...

8 Huhti 20247min

Risk stratification and guidelines in AML management

Risk stratification and guidelines in AML management

The AML Hub was pleased to speak to Gail Roboz, Weill Cornell Medicine, New York, US, and Naval Daver, MD Anderson Cancer Center, Houston, US. We asked about risk stratification and guidelines in acut...

8 Tammi 202411min

How are new fludarabine conditioning combinations impacting transplant outcomes?

How are new fludarabine conditioning combinations impacting transplant outcomes?

During the virtual 48th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), the AML Hub spoke with Eleni Gavriilaki, George Papanikolaou General Hospital of Thessalonik...

22 Huhti 20226min

Should pre-transplant MRD be used to guide treatment in AML?

Should pre-transplant MRD be used to guide treatment in AML?

During the EHA2021 Virtual Congress, the AML Hub spoke with Arnon Nagler, Tel Aviv University, Tel Aviv, IL. We asked, Should pre-transplant measurable residual disease (MRD) be used to guide treatmen...

10 Heinä 20216min

Should pre-transplant MRD be used to guide treatment in AML?

Should pre-transplant MRD be used to guide treatment in AML?

During the EHA2021 Virtual Congress, the AML Hub spoke with Charles Craddock, Queen Elizabeth Hospital Birmingham, Birmingham, UK. We asked, Should pre-transplant minimal residual disease (MRD) be use...

25 Kesä 202113min

Should pre-transplant MRD be used to guide treatment in AML?

Should pre-transplant MRD be used to guide treatment in AML?

During the EHA2021 Virtual Congress, the AML Hub spoke with Gert Ossenkoppele, Amsterdam UMC, Amsterdam, NL. We asked, Should pre-transplant minimal residual disease (MRD) be used to guide treatment i...

23 Kesä 20215min

Can HMA maintenance therapy improve eligibility for HSCT?

Can HMA maintenance therapy improve eligibility for HSCT?

During the 2021 TCT Meetings Digital Experience, the AML Hub spoke to Farhad Ravandi, MD Anderson Cancer Center, Houston, US. We asked, Can HMA maintenance therapy improve eligibility for HSCT? Ravand...

17 Maalis 20215min

Suosittua kategoriassa Koulutus

rss-murhan-anatomia
voi-hyvin-meditaatiot-2
psykopodiaa-podcast
adhd-podi
rss-narsisti
psykologia
kesken
rss-vapaudu-voimaasi
rahapuhetta
rss-niinku-asia-on
rss-liian-kuuma-peruna
rss-duodecim-lehti
rss-valo-minussa-2
rss-luonnollinen-synnytys-podcast
rss-tietoinen-yhteys-podcast-2
aamukahvilla
rss-uskonto-on-tylsaa
rss-honest-talk-with-laurrenna
nakokulmia-rikollisuudesta-irrottautumiseen
rss-ai-mita-siskopodcast