Symposium | FLT3 mutations in AML: Types, prevalence, and clinical significance
AML Hub14 Tammi

Symposium | FLT3 mutations in AML: Types, prevalence, and clinical significance

The AML Hub held a webinar on November 19, 2025, titled, “Understanding the differences between FLT3-ITD and -TKD mutations in AML: Implications for clinical practice.” Here, we share one of the presentations, by Jorge Sierra, Hospital de la Santa Creu i Sant Pau, Barcelona, ES, discussing the types, prevalence, and clinical significance of FLT3 mutations in acute myeloid leukemia (AML).


Sierra provided an overview of the role of FLT3-internal tandem duplication (ITD) and -tyrosine kinase domain (TKD) mutations in AML pathogenesis, and the differences in their molecular characteristics. He then discussed the prognostic value of FLT3-ITD and -TKD and concomitant mutations in patients with AML, and current risk stratification guidelines.


This educational resource is independently supported by Daiichi Sankyo. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource.

Hosted on Acast. See acast.com/privacy for more information.

Jaksot(33)

What are the challenges associated with CAR T-cell therapy in patients with AML?

What are the challenges associated with CAR T-cell therapy in patients with AML?

During the 6th European CAR T-Cell Meeting, the AML Hub spoke to Sarah Tettamanti, Tettamanti Foundation Research Center, Monza, IT. We asked, What are the challenges associated with CAR T-cell therap...

25 Huhti 20249min

How might the MORPHO trial of gilteritinib impact clinical practice?

How might the MORPHO trial of gilteritinib impact clinical practice?

The AML Hub spoke to Charles Craddock, Queen Elizabeth Hospital Birmingham, Birmingham, UK at ASH 2023. We asked, How might the MORPHO trial of gilteritinib impact clinical practice? Hosted on Acast. ...

8 Huhti 20247min

Risk stratification and guidelines in AML management

Risk stratification and guidelines in AML management

The AML Hub was pleased to speak to Gail Roboz, Weill Cornell Medicine, New York, US, and Naval Daver, MD Anderson Cancer Center, Houston, US. We asked about risk stratification and guidelines in acut...

8 Tammi 202411min

How are new fludarabine conditioning combinations impacting transplant outcomes?

How are new fludarabine conditioning combinations impacting transplant outcomes?

During the virtual 48th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), the AML Hub spoke with Eleni Gavriilaki, George Papanikolaou General Hospital of Thessalonik...

22 Huhti 20226min

Should pre-transplant MRD be used to guide treatment in AML?

Should pre-transplant MRD be used to guide treatment in AML?

During the EHA2021 Virtual Congress, the AML Hub spoke with Arnon Nagler, Tel Aviv University, Tel Aviv, IL. We asked, Should pre-transplant measurable residual disease (MRD) be used to guide treatmen...

10 Heinä 20216min

Should pre-transplant MRD be used to guide treatment in AML?

Should pre-transplant MRD be used to guide treatment in AML?

During the EHA2021 Virtual Congress, the AML Hub spoke with Charles Craddock, Queen Elizabeth Hospital Birmingham, Birmingham, UK. We asked, Should pre-transplant minimal residual disease (MRD) be use...

25 Kesä 202113min

Should pre-transplant MRD be used to guide treatment in AML?

Should pre-transplant MRD be used to guide treatment in AML?

During the EHA2021 Virtual Congress, the AML Hub spoke with Gert Ossenkoppele, Amsterdam UMC, Amsterdam, NL. We asked, Should pre-transplant minimal residual disease (MRD) be used to guide treatment i...

23 Kesä 20215min

Can HMA maintenance therapy improve eligibility for HSCT?

Can HMA maintenance therapy improve eligibility for HSCT?

During the 2021 TCT Meetings Digital Experience, the AML Hub spoke to Farhad Ravandi, MD Anderson Cancer Center, Houston, US. We asked, Can HMA maintenance therapy improve eligibility for HSCT? Ravand...

17 Maalis 20215min

Suosittua kategoriassa Koulutus

rss-murhan-anatomia
voi-hyvin-meditaatiot-2
psykopodiaa-podcast
adhd-podi
rss-narsisti
psykologia
kesken
rahapuhetta
rss-niinku-asia-on
rss-vapaudu-voimaasi
rss-liian-kuuma-peruna
rss-duodecim-lehti
rss-luonnollinen-synnytys-podcast
rss-tietoinen-yhteys-podcast-2
aamukahvilla
rss-uskonto-on-tylsaa
rss-valo-minussa-2
rss-honest-talk-with-laurrenna
rss-opeklubi
rss-psykalab